Reprints / Talks / Interviews

Methodologic         Clinical/Epidemiologic


Sample Size Estimation for Random-effects Models: Balancing Precision and Feasibility in Panel Studies
Epidemiology. November 2017.
(email me if you cannot access that website)

The mystery data challenge   SIGNIFICANCE. April 2017.
or here if you cannot access that website.

Hanley JA.
Correction of Selection Bias in Survey Data: Is the Statistical Cure Worse Than the Bias?
American Journal of Public Health
American Journal of Epidemiology. 2017.

Hanley JA.
Simple and multiple linear regression: sample size considerations
J Clin Epidemiol. 2016

Hajna S, Buckeridge DL and Hanley JA.
Substantiating the impact of John Snow's contributions using data deleted during the 1936 reprinting of his original essay On the Mode of Communication of Cholera
Int. J. Epidemiol. (2015) doi: 10.1093/ije/dyv164.
First published online: August 26, 2015

Hanley JA.
'Immortal Time' Blunders: history, identification, severity
Interdisciplinary FRIAS Junior Researcher Conference 2016:
Avoiding Bias induced by Design and Analysis in Life History Cohort Studies
Freiburg Institute for Advanced Studies, Germany. Sept. 21-23, 2016

Liu Z(A), Hanley JA, Saarela O, Dendukuri N   A Conditional Approach to Measure Mortality Reductions Due to Cancer Screening
International Statistical Review (Early View)
[full pdf, in case you have limited access]

***** other articles/presentations on Cancer Screening *****

Genest C, Hanley JA   Prévoir les ressources nécessaires pur atteindre son but: Le cas d'espèce de la sonde Rosetta (Un lien utile entre le discret [Poisson] et le continu [Gamma] ).   Accromαth Vol. 10 hiver-printemps 2015

Liu Z, Rich B, Hanley JA   Recovering the raw data behind a non-parametric survival curve
Systematic Reviews 2014 Dec 30;3(1):151. doi: 10.1186/2046-4053-3-151.

Hanley J   How Deep is the Ocean?
Significance magazine, 2014

Hanley J   Epidemiology: Unraveling Medical Mysteries (lecture)
Mini-Med Epidemiology Series "What makes people sick", Oct-Nov 2014.
Video on demand, Canal Savoir.   Supporting material (JH's website)

Saarela O and Hanley JA
Case-Base Methods for Studying Vaccination Safety
Biometrics, online first

Hanley JA, Saarela S, Stephens DA, Thalabard J-C.
hGH isoform differential immunoassays applied to blood samples from athletes: Decision limits for anti-doping testing
Growth Hormone & IGF Research 24 (2014) 205-215

Hanley JA and Foster BJ.  Avoiding blunders involving immortal time
International Journal of Epidemiology, June 2014     Correspondence

Chiolero A, Paradis P, Rich B, and Hanley J.   Assessing the relationship between the baseline value of a continuous variable and subsequent change over time
Front. Public Health 1:29. doi: 10.3389/fpubh.2013.00029

Hanley J.   Charles Metz: Scholar (tribute)

Moore L, Hanley JA, Turgeon AF, Lavoie A   Comparing regression-adjusted mortality to standardized mortality ratios for trauma center profiling.
J Emerg Trauma Shock. 2012 Oct;5(4):333-7. doi: 10.4103/0974-2700.102404.

Hanley J. How-your-birth-month-affects-your-future
-- Interview Global TV, Montreal, August 5, 2013.

Hanley J. Scientific reasoning, statistical thinking, measurement issues, & use of graphics: examples from research on children
-- Presentation at Royal Children's Hospital and Murdoch Childrens Research Institute, Melbourne, Australia, March, 2012

Hanley JA.   Things They Don't Teach You in Graduate School   Expanded version of after-dinner-remarks at Conference of Applied Statisticians of Ireland, May 18, 2006

Hanley JA. A Conversation With Olli Miettinen.
Epidemiology ('Voices' series) 23(3):495-499, May 2012.
Video (entire interview)

Bellera CA, Foster BJ, Hanley JA Calculating Sample Size in Anthropometry
Chapter 1 in V.R. Preedy (ed.), Handbook of Anthropometry: Physical Measures of Human Form in Health and Disease, DOI 10.1007/978-1-4419-1788-1_1, Springer Science+Business Media, LLC 2012

Hanley JA and Moodie EEM
Sample Size, Precision and Power Calculations: A Unified Approach
J Biomet Biostat 2011, 2:5.

Sadhukhan S, Liu Z, and Hanley JA. Practical and efficient estimates of one's accuracy in darts. (Correspondence) J. R. Statist. Soc. A (2011) 174, Part 4, pp. 1175-1177.

Bellera CA, Julien M, Hanley JA. Normal Approximations to the Distributions of the Wilcoxon Statistics: Accurate to What N? Graphical Insights. Journal of Statistics Education, Volume 18, Number 2, (2010)

J Hutcheon, A Chiolero and J Hanley Random measurement error and regression dilution bias BMJ 2010;340: 1402- 1406. c2289, doi: 10.1136/bmj.c2289 (Published 23 June 2010)

J Hanley and E Turner. Age in medieval plagues and pandemics: Dances of Death or Pearson's bridge of life? significance, volume 7 issue 2, June 2010, p 85-87. published online: May 18 2010. DOI: 10.1111/j.1740-9713.2010.00426.x     website

CANCER SCREENING - - - - - - - - -  

The loneliness of the long-distance trialist (JH)  

Hanley JA Analysis of Mortality Data From Cancer Screening Studies: Looking in the Right Window Epidemiology, Vol 16, No. 6, November 2005, pp 786-790.

Hanley JA   Mortality reductions produced by sustained prostate cancer screening have been underestimated       Supplementary Material
Journal of Medical Screening (2010), 17(3) 147-151.
Hanley JA   Measuring mortality reductions in cancer screening trials.
Epidemiologic Reviews, 2011. Theme Issue on Screening
      Journal       Author's website       WebFigures/Table
Hanley JA, Liu Z, McGregor M.   p800 in Letters re UK Panel report on The benefits and harms of breast cancer screening. Vol381 March9,2013
Liu Z, Hanley JA and Strumpf EC.   Projecting the yearly mortality reductions due to a cancer screening programme
J Med Screen 20(3) 157-164 (2013)
Hanley JA, McGregor M, Liu Z, Strumpf EC, Dendukuri N.   Measuring the Mortality Impact of Breast Cancer Screening
Can J Public Health 2013;104(7):e437-e442.
Liu Z(A), Hanley JA, Saarela O, Dendukuri N   A Conditional Approach to Measure Mortality Reductions Due to Cancer Screening
International Statistical Review (Early View)
PRESENTATIONS / INTERVIEW on this same topic:
*** 2010.04.09: CANNeCTIN Biostat. Methodology Videoconference
          slides   video

*** Annual Meeting of Statistical Society of Canada, 2010.05.26

*** 2011.02.26 (by Video)
          Video(.wmv, 228MB)     slides, for printing     for on screen viewing

*** 2011.06.23: North American Congress of Epidemiology Symposium.
      Randomized Trials of Cancer Screening: How Useful are They?

*** 2011.08.24: International Society of Clinical Biostatistics.
      How big are the mortality reductions produced by cancer Screening?
      Why do so many trials say only 20%?

*** 2012.03.08: Up Close (Interview) University of Melbourne
          link to transcript and podcast
*** 2014.10.22: 51ST ANNUAL CLINICAL DAY, Jewish General Hospital

- - - - - - - - - - - - -

Hanley JA, Hutcheon JA. Does children's energy intake at one meal influence their intake at subsequent meals? Or do we just think it does? Paediatric and Perinatal Epidemiology (pages 241-248) 2010

Related material:

Turner EL and Hanley JA Cultural imagery and statistical models of the force of mortality: Addison, Gompertz and Pearson. J. R. Statist. Soc. A (2010) 173, Part 3, pp. 483-499.     slides

Lévesque LE, Hanley JA, Kezouh A, Suissa S. Problem of immortal time bias in cohort studies: example using statins for preventing progression of diabetes. BMJ. 2010 Mar 12;340:b5087. doi: 10.1136/bmj.b5087.

Bellera CA, Hanley JA, Joseph L, Albertsen PC. A statistical evaluation of rules for biochemical failure after radiotherapy in men treated for prostate cancer. Int J Radiat Oncol Biol Phys. 2009 Dec 1;75(5):1357-63. Epub 2009 Apr 22.

Hanley JA and Miettinen OS. Fitting Smooth-in-Time Prognostic Risk Functions via Logistic Regression The International Journal of Biostatistics, Vol 5, Issue 1 2009 Article 3
Ashton Biometric Lecture Biomathematics & Biostatistics Symposium,
University of Guelph, September 3, 2008     pdf
International Society for Clinical Biostatistics, Prague, 2009. pdf

Hanley JA. The statistical legacy of William Sealy Gosset ("Student"). Community Dent Health. 2008 Dec;25(4):194-5.

Hanley JA and Dendukuri N. Efficient sampling approaches to address confounding in database studies Stat Methods Med Res. 2008 Sep 24. [Epub ahead of print]

Julien M and Hanley JA. Profile-specific survival estimates: Making reports of clinical trials more patient-relevant Clinical Trials 2008; 5: 107-115. Presentation

Bellera CA, Hanley JA, Joseph L, Albertsen PC. Hierarchical changepoint models for biochemical markers illustrated by tracking postradiotherapy prostate-specific antigen series in men with prostate cancer. Ann Epidemiol. 2008 Apr;18(4):270-82.

Bellera CA, Hanley JA, Joseph L, Albertsen PC. Detecting trends in noisy data series: application to biomarker series. Am J Epidemiol. 2008 May 1;167(9):1130-9. Epub 2008 Feb 25

Hanley JA, Julien M, Moodie EEM. Student's z, t, and s: What if Gosset had R? The American Statistician, February 2008, Vol. 62, No. 1. pp. 64-69.

Hanley JA The Breslow Estimator of the Nonparametric Baseline Survivor Function in Cox's Regression Model: Some Heuristics Epidemiology, Volume 19, Number 1, January 2008 101-102.

Sylvestre M-P, Huszti E and Hanley JA. Do Oscar Winners Live Longer than Less Successful Peers? A Reanalysis of the Evidence. Annals of Internal Medicine. 5 September 2006 | Volume 145 Issue 5 | Pages 361-363

Bellera CA, Hanley JA. Required sample size when estimating regression-based reference limits. J Clin Epidemiol. 2007 Jun;60(6):610-5. Epub 2007 Jan 16.

Hanley JA, Macgibbon B. Creating non-parametric bootstrap samples using Poisson frequencies. Computer Methods and Programs in Biomedicine. 2006 Jul;83(1):57-62. Epub 2006 May 30.

Hanley JA, Carrieri MP, Serraino D. Statistical fallibility and the longevity of popes: William Farr meets Wilhelm Lexis. Int J Epidemiol. 2006 Jun;35(3):802-5. Epub 2006 Mar 16.

Hanley JA, Miettinen OS. An Unconditional-like Structure for the Conditional Estimator of Odds Ratio from 2 x 2 Tables. Biometrical Journal 48 (2006) 1, 23�34 DOI: 10.1002/bimj.200510167

Hanley JA, Teltsch D. The PDF of a Function of a Random Variable: Teaching its Structure by Transforming Formalism into Intuition. The American Statistician, Vol. 60, No. 1, February 2006 pp.61-67.

Albertsen PC, Hanley JA, Barrow GH, Penson DF, Kowalczyk PDH, Sanders MM, Fine J. Prostate Cancer and the Will Rogers Phenomenon J Natl Cancer Inst 2005;97:1248-53.

Hanley JA, Csizmadi I, Collet J-P. Two-Stage Case-Control Studies: Precision of Parameter Estimates and Considerations in Selecting Sample Size. . Am J Epidemiol. 2005 Dec 15;162(12):1225-34. Epub 2005 Nov 3.

Hanley JA Receiver Operating Characteristic (ROC) Curves Encyclopedia of Biostatistics. P Armitage and Theodore Colton (Editors) Wiley, 2005.

Hanley JA Analysis of Mortality Data From Cancer Screening Studies: Looking in the Right Window Epidemiology, Vol 16, No. 6, November 2005, pp 786-790.

Hanley JA. "Transmuting" women into men: Galton's family data on human stature. The American Statistician, 58(3) 237-243. August 2004.
Also: poster [ 57MB !!! ] presented at IBC2004 and at CASI2005.

Hanley JA, Turner E, Bellera C, Teltsch D. How long did their hearts go on? A Titanic study. British Medical Journal, Dec 2003; 327: 1457 - 1458. (Christmas Edition)

Hanley JA. Negassa A. Edwardes M. Forrester JE. "Statistical analysis of correlated data using generalized estimating equations (GEE): an orientation". American Journal of Epidemiology. 2003 Feb 15;157(4):364-75.

Wolfe R, HANLEY J If we're so different, why do we keep overlapping? When 1 plus 1 doesn't make 2. Canadian Medical Association Journal. 2002 Jan 8;166(1):65-6.

Hajian-Tilaki K.O., Hanley JA: "Comparison of the three methods for estimating the standard error of the area under the curve in ROC analysis of quantitative data". Academic Radiology, 2002 Nov; 9(11):1278-85.

Hanley JA, Joseph, L, Platt RW, Chung MK, Bélisle P:
" Visualizing the median as the minimum deviation location"
The American Statistician 55(2): 150-152, May 2001.
Fig 1 [colour];         java applet

Hanley JA "A heuristic approach to the formulas for population attributable fraction". Journal of Epidemiology and Community Health 2001; 55:508-514.

Hanley JA Theriault G. "Simpson's paradox in meta-analysis."
Epidemiology 2000 Sep;11(5):613-4.

Hanley JA. Negassa A. Edwardes M. "GEE analysis of negatively correlated binary responses: a caution". Statistics in Medicine , 19(5):715-722, 2000 Mar 15.

Hanley JA, Lippman A. Where do you stand? Notions of a statistical `centre'. Teaching Statistics. Vol 22, No. 2, Summr 1999.

Albertsen PC, Hanley JA, Murphy-Setzko M. Statistical considerations when assessing outcomes following treatment for prostate cancer. J Urol. 1999 Aug;162(2):439-44. Review.

Hanley JA   ROC curves
Encyclopedia of Biostatistics

Hajian-Tilaki KO, Hanley JA, Joseph L, Collet JP. A comparison of parametric and nonparametric approaches to ROC analysis of quantitative diagnostic tests. Med Decis Making. 1997 Jan-Mar;17(1):94-102.

Hanley JA and Hajian-Tilaki KO. Sampling Variability of Nonparametric Estimates of the Areas under Receiver Operating Characteristic Curves: An Update. Academic Radiology, 1997 4:49-58.

Hanley JA   The use of the 'binormal' model for parametric roc analysis of quantitative diagnostic tests.   Statistics in Medicine 1996; 15, 1575-1585.

Hanley JA, Hagen CA, Shiferaw T: Confidence intervals and sample-size calculations for the sisterhood method of estimating maternal mortality. Studies in Family Planning 27(4): 220-227, 1996.

Hanley JA: MacGibbon B: The Poisson distribution and "multiple events" cell occupancy problems. Biometrics, 1995, 51(4)1557-1561.

Altman DG, Goodman SN: Transfer of Technology From Statistical Journals to the Biomedical Literature . JAMA. 1994;272:129-132.

Zeiss EE, Hanley JA. Mantel-Haenszel techniques and logistic regression: always examine one's data first and don't overlook the simpler techniques. Paediatr Perinat Epidemiol. 1992 Jul;6(3):311-5.

Hanley JA: Jumping to coincidences: defying odds in the realm of the preposterous. American Statistician, 1992, 46(3) 197-202.

Hanley JA, Burke JF, Locke JA, Boyle CM. Sampling events in space and time: a case study of burn injuries. Burns. 1991 Apr;17(2):104-9.

Hanley JA. The place of statistical methods in radiology (and in the bigger picture). Invest Radiol. 1989 Jan;24(1):10-6.

Hanley JA. R.O.C. methodology: the State of the Art. Crit. Rev in Diagnostic Imaging. 1989

Hanley JA. Alternative Approaches to Receiver Operating Characteristic Analyses. Radiology 1988;168:568-570.

Hanley JA. The Robustness of the Binormal Assumptions Used in Fitting ROC Curves. Med Decis Making. 1988 Vol 8:197-203.

Hanley JA, Parnes MN: Nonparametric estimation of a multivariate distribution in the presence of censoring. Biometrics 39: 129-139, 1983.

Hanley JA, Begg CB. Response to ROC steady. Med Decis Making. 1987 Oct-Dec;7(4):244-6.

Hanley James A. Standard Error of the Kappa Statistic. Psychological Bulletin. 1987;102(2):315-321.

Hanley JA. Evaluating primary prevention programmes against cancer. Bull World Health Organ. 1986;64(2):311-20.

Hanley JA. Lotteries and Probability: Three Case Reports Teaching Statistics. 1984

McNeil BJ, Hanley JA, Funkenstein HH, Wallman J. Paired receiver operating characteristic curves and the effect of history on radiographic interpretation. CT of the head as a case study. Radiology. 1983 Oct;149(1):75-7.

Hanley JA, McNeil BJ. A method of comparing the areas under receiver operating characteristic curves derived from the same cases. Radiology. 1983 Sep;148(3):839-43.

Hanley JA, Lippman-Hand, A. Quand rien ne va mal, peut-on dire que tout va bien? JAMA, Juin 1983;7(70): 722-725.

Hanley JA, Lippman-Hand A. If nothing goes wrong, is everything all right? Interpreting zero numerators. JAMA. 1983 Apr 1;249(13):1743-5.

Hanley JA. Appropriate uses of multivariate analysis. Annu Rev Public Health. 1983;4:155-80.

Hanley JA, McNeil BJ. The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology. 1982 Apr;143(1):29-36.

Hanley JA, McNeil BJ. Maximum attainable discrimination and the utilization of radiologic examinations. J Chronic Dis. 1982;35(8):601-11.

Hanley JA. A Language for Computer Generation of Medical Data Forms Biometrics, Vol. 34, No. 2 (Jun., 1978), pp. 288-297.

Moertel CG, Hanley JA. The effect of measuring error on the results of therapeutic trials in advanced cancer. Cancer. 1976 Jul;38(1):388-94.

Hanley JA, Robinson JC. Cigarette smoking and the young: a national survey. Can Med Assoc J. 1976 Mar 20;114(6):511-7.


Tamblyn R, Eguale T, Buckeridge DL, Huang A, Hanley J, Reidel K, Shi S, Winslade N. The effectiveness of a new generation of computerized drug alerts in reducing the risk of injury from drug side effects: a cluster randomized trial.   J Am Med Inform Assoc. 2012 Jan 12.

Teltsch DY, Hanley J, Loo V, Goldberg P, Gursahaney A, Buckeridge DL.
Infection acquisition following intensive care unit room privatization   Arch Intern Med. 2011 Jan 10;171(1):32-8.

Burchell AN, Coutleée F, Tellier PP, Hanley J, Franco EL. Genital transmission of human papillomavirus in recently formed heterosexual couples.   J Infect Dis. 2011 Dec;204(11):1723-9. Epub 2011 Oct 7.

Foster BJ, Platt RW, Dahhou M, Zhang X, Bell LE, Hanley JA. The impact of age at transfer from pediatric to adult-oriented care on renal allograft survival.   Pediatr Transplant. 2011 Nov;15(7):750-9. doi: 10.1111/j.1399-3046.2011.01567.x. Epub 2011 Aug 23.

Burchell AN, Tellier PP, Hanley J, Coutlée F, Franco EL.
Human papillomavirus infections among couples in new sexual relationships   Epidemiology. 2010 Jan;21(1):31-7.

Albertsen PC, Hanley JA, Penson DF, Barrows G, Fine J.
13-year outcomes following treatment for clinically localized prostate cancer in a population based cohort.   J Urol. 2007 Mar;177(3):932-6.

Albertsen PC, Hanley JA, Fine J. 20-Year Outcomes Following Conservative Management of Clinically Localized Prostate Cancer.   JAMA. 2005;293:2095-2101.

Menzies D, Popa J, Hanley JA , Rand T, Milton DK
Effect of ultraviolet germicidal lights installed in office ventilation systems on workers' health and wellbeing: double-blind multiple crossover trial   The Lancet, Volume 362, Issue 9398, 29 November 2003, Pages 1785-1791.

Albertsen PC, Hanley JA,Gleason DF, Barry MJ. Competing Risk Analysis of Men Aged 55 to 74 Years at Diagnosis Managed Conservatively for Clinically Localized Prostate Cancer   JAMA. 1998;280:975-980

Menzies R, Tamblyn R, Farant JP, Hanley JA, Nunes F, Tamblyn R
The effect of varying levels of outdoor air supply on the symptoms of sick building syndrome   New England Journal of Medicine 328: 821-827, 1993.

Updated: Oct. 24, 2017