(since 1995)

59. Nandish Khanra, Patricia MGE Brown, Amanda M Perozzo, Derek Bowie and Joel Meyerson

Architecture and structural dynamics of the heteromeric GluK2/K5 kainate receptor.

eLife. 2021 Mar 16.

58. Bowie D.

Neurotransmitter-gated ion channels, still front and centre stage.

J Physiol. 2021 Jan 14.

On the Cover!

57. Saeed Farjami, Ryan P.D. AlexanderDerek Bowie and Anmar Khadra

Bursting in Cerebellar Stellate Cells Induced by Pharmacological Agents: Non-sequential Spike Adding

PLOS Computational Biology. 2020 Dec 14.

56. Ryan P.D. Alexander and Derek Bowie

Intrinsic plasticity of cerebellar stellate cells is mediated by NMDA receptor regulation of voltage‐gated Na+ channels

The Journal of Physiology. 2020 Nov 4.

Selected as Editor's Choice in the 15 January 2021 Issue (Volume 599 Number 2)!

55. G. Brent Dawe, Patricia M.G.E. Brown and Derek Bowie

AMPA and Kainate Receptors

The Oxford Handbook of Neuronal Ion Channels (Book Chapter). 2020 Oct.

54. Erik Larson, Michael Accardi, Ying Wang, Martina D'Antoni, Benyamin Karimi, Tabrez Siddiqui and Derek Bowie

Nitric oxide signaling strengthens inhibitory synapses of cerebellar molecular layer interneurons through a GABARAP-dependent mechanism

The Journal of Neuroscience. 2020 March 13.

53. Saeed Farjami, Ryan P.D. AlexanderDerek Bowie and Anmar Khadra

Switching in Cerebellar Stellate Cell Excitability in Response to a Pair of Inhibitory/Excitatory Presynaptic Inputs: A Dynamical System Perspective

Neural Computation. 2020 Feb 18.

52. John Mitry, Ryan P.D. AlexanderSaeed FarjamiDerek Bowie and Anmar Khadra

Modeling excitability in cerebellar stellate cells: Temporal changes in threshold, latency and frequency of firing

Commun Nonlinear Sci Numer Simulat. 2019 Sept 19.

51. Ryan P.D. AlexanderJohn MitryVasu SareenAnmar Khadra and Derek Bowie

Cerebellar stellate cell excitability is coordinated by shifts in the gating behavior of voltage-gated Na+ and A-type K+ channels

eNeuro. 2019 May 20.

50. G. Brent Dawe, Md. Fahim Kadir, Raminta Venskutonyte, Amanda M. Perozzo, Yuhao Yan, Ryan P.D. Alexander, Camilo Navarrete, Eduardo A. Santander, Marika Arsenault, Christian Fuentes, Mark R.P. Aurousseau, Karla Frydenvang, Nelson P. Barrera, Jette S. Kastrup, J. Michael Edwardson, and Derek Bowie.

Nanoscale Mobility of the Apo State and TARP Stoichiometry Dictate the Gating Behavior of Alternatively Spliced AMPA Receptors.

Neuron. 2019 Apr 30.

Med e-News

49. Bowie D.

Polyamine-mediated channel block of ionotropic glutamate receptors and its regulation by auxiliary proteins.

J Biol Chem. 2018 Oct 17.

48. Bowie D.

Shared and unique aspects of ligand- and voltage-gated ion-channel gating.

J Physiol. 2018 May 15.

47. Brown PMGE, McGuire H, Bowie D.

Stargazin and cornichon-3 relieve polyamine block of AMPA receptors by enhancing blocker permeation.

J Gen Physiol. 2017 Dec 8.

JGP Research News

46. Paramo T, Brown PMGE, Musgaard M, Bowie D, Biggin PC.

Functional Validation of Heteromeric Kainate Receptor Models.

Biophysical Journal. 2017 Sept 19.

45. Liebsch F, Aurousseau MRP, Bethge T, McGuire H, Scolari S, Herrmann A, Blunck R, Bowie D, Multhaup G.

Full-length Cellular Beta-secretase Has a Trimeric Subunit Stoichiometry, and Its Sulfur-rich Transmembrane Interaction Site Modulates Cytosolic Copper Compartmentalization.

The Journal of Biological Chemistry. 2017 Jun 21.

44. Krogsgaard-Larsen N, Delgar CG, Koch K, Brown PM, Møller C, Han L, Huynh TH, Hansen SW, Nielsen B, Bowie D, Pickering DS, Kastrup JS, Frydenvang K, Bunch L.

Design and Synthesis of a Series of l-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic Acid.

The Journal of Medicinal Chemistry. 2016 Dec 22.

43. G. Brent Dawe, Maria Musgaard, Mark R.P. Aurousseau, Naushaba Nayeem, Tim Green, Philip C. Biggin, Derek Bowie.

Distinct Structural Pathways Coordinate the Activation of AMPA Receptor-Auxiliary Subunit Complexes.

Neuron. 2016 Mar 16

McGill Newsroom

F1000 Recommendation

42. Brown PM, Aurousseau MR, Musgaard M, Biggin PC, Bowie D.

Kainate receptor pore-forming and auxiliary subunits regulate channel block by a novel mechanism.

The Journal of Physiology. 2016 Apr 1

41. Aurousseau MRP, McGuire H, Blunck R and Bowie D.

Ionotropic Glutamate Receptor Technologies

2015. Volume 106 of the series Neuromethods pp 15-30

40. Jorge L. Cueva Vargas, Ingrid K. Osswald, Nicolas Unsain, Mark R. Aurousseau, Philip A. Barker, Derek Bowie and Adriana Di Polo.

Soluble Tumor Necrosis Factor Alpha Promotes Retinal Ganglion Cell Death in Glaucoma via Calcium-Permeable AMPA Receptor Activation.

The Journal of Neuroscience. 2 September 2015

39. Bowie D, Attwell D.

Coupling cellular metabolism to neuronal signalling.

The Journal of Physiology. Aug 2015

38. Accardi MV, Brown PMGE, Miraucourt LS, Orser BA, Bowie D.

α6-Containing GABAA Receptors Are the Principal Mediators of Inhibitory Synapse Strengthening by Insulin in Cerebellar Granule Cells.

The Journal of Neuroscience. 2015

McGill Newsroom

37. Paolo Schiavini, G. Brent Dawe, Derek Bowie, Nicolas Moitessier

Discovery of novel small-molecule antagonists for GluK2

Bioorganic and Medicinal Chemistry Letters. 2015

36. Demmer CS, Møller C, Brown PM, Han L, Pickering DS, Nielsen B, Bowie D, Frydenvang K, Kastrup JS, Bunch L.

Binding Mode of an α-Amino Acid-Linked Quinoxaline-2,3-dione Analogue at Glutamate Receptor Subtype GluK1.

ACS Chemical Neuroscience. 2015

35. Bowie D.

Ionotropic glutamate receptors: alive and kicking

The Journal of Physiology. 2015

34. Bowie D.

Ionotropic glutamate receptors made crystal clear

Trends in Neuroscience. 2014

33. Dawe GB, Aurousseau MR, Daniels BA, Bowie D.

Retour Aux Sources: Defining the structural basis of glutamate receptor activation.

The Journal of Physiology. 2014

32. Penna A, Wang DS, Yu J, Lecker I, Brown PM, Bowie D, Orser BA

Hydrogen Peroxide Increases GABAA Receptor-Mediated Tonic Current in Hippocampal Neurons.

The Journal of Neuroscience. 2014

31. Accardi MV, Daniels BA, Brown PM, Fritschy JM, Tyagarajan SK, Bowie D.

Mitochondrial reactive oxygen species regulate the strength of inhibitory GABA-mediated synaptic transmission.

Nature Communications. 2014


Press Release

Le Devoir article

30. Dawe GB, Musgaard M, Andrews ED, Daniels BA, Aurousseau MR, Biggin PC, Bowie D.

Defining the structural relationship between kainate-receptor deactivation and desensitization.

Nature Structural and Molecular Biology. 2013



Press Release

29. Daniels BA, Andrews ED, Aurousseau MR, Accardi MV, Bowie D.

Crosslinking the ligand-binding domain dimer interface locks kainate receptors out of the main open state.

The Journal of Physiology. 2013

28. Hugo McGuire*, Mark R. P. Aurousseau*, Derek Bowie, and Rikard Blunck

Automating single subunit counting of membrane proteins in mammalian cells

The Journal of Biological Chemistry. 2012
*These authors contributed equally to this work

F1000 Recommendation

27. Aurousseau, M.R.P., Osswald, I.K. and Bowie, D.

Thinking of Co2+-staining explant tissue or cultured cells? How to make it reliable and specific.

The European Journal of Neuroscience. 2012

26. Bowie, D.

Ligand-gated ion channels: From genes to behaviour.

The Journal of Physiology. 2011


25. Bowie, D.

Redefining the classification of AMPA-selective ionotropic glutamate receptors.

The Journal of Physiology. 2012

24. Maclean,D.M., and Bowie,D.

Transmembrane AMPA receptor regulatory protein regulation of competitive antagonism: a problem of interpretation

The Journal of Physiology. 2011


23. Lachance-Touchette, P.*, Brown, P.*, Meloche, C., Kinirons, P., Lapointe, L., Lortie, A., Carmant, L., Bedford, F., Bowie, D. & Cossette, P.

Novel α1 and γ2 GABAA receptor mutations in families with idiopathic generalized epilepsy.

The European Journal of Neuroscience 2011

*Both authors contributed equally to this work.



22. D. M. MacLean, A. Y. C. Wong, A-M. Fay, and D. Bowie

Cations But Not Anions Regulate the Responsiveness of Kainate Receptors

The Journal of Neuroscience. 2011

21. Bowie, D. and McKinney, R.A.

Neurophysiology of inhibitory and excitatory amino acid receptors

The Journal of Physiology. 2010

20. Bowie, D.

Ion-dependent gating of kainate receptors

The Journal of Physiology. 2010


19. Lebrun-Julien, F., Duplan, L., Pernet, V., Osswald, I.K., Sapieha, P., Bourgeois, P., Dickson, K.M., Bowie, D., Barker, P. and Di Polo, A.

Excitotoxic death of retinal neurons in vivo occurs via a non-cell-autonomous mechanism

The Journal of Neuroscience. 2009


18. Fay, A-M., Corbeil, C., Brown, P., Moitessier, N. and Bowie, D.

Functional characterisation and in silicodocking of full and partial agonists acting on GluK2 kainate receptors

Molecular Pharmacology. 2009


17. Zhao, B., Wong, A.Y., Murshid, A., Bowie, D., Presley, J.F. and Bedford, F.K.

Identification of a novel di-leucine motif mediating K(+)/Cl(-) cotransporter KCC2 constitutive endocytosis

Cellular Signaling. 2008

16. Bowie, D.

Ionotropic Glutamate Receptors and CNS Disorders

CNS and Neurological Disorders-Drug Targets. 2008

15. Wong, A.Y.C., MacLean, D.M. and Bowie, D.

Na+ / Cl- dipole couples agonist binding to kainate receptor activation

The Journal of Neuroscience. 2007

14. Osswald, I.K., Galan, A. and Bowie, D.

Light triggers expression of philanthotoxin-insensitive Ca2+-permeable AMPA receptors in the developing rat retina

The Journal of Physiology. 2007


13. Wong, A.Y.C., Fay, A-M,  and Bowie, D.

External ions are co-activators of kainate receptors

The Journal of Neuroscience. 2006

Lay Press

12. Fay, A-M,  and Bowie, D.

Concanavalin-A reports agonist-induced conformational changes in the intact GluR6 kainate receptor

The Journal of Physiology. 2006

11. Bowie, D., Garcia, E.P., Marshall, J, Traynelis, S.F. and Lange, G.D.

Allosteric regulation and spatial distribution of kainate receptors bound to ancillary proteins.

The Journal of Physiology. 2003

10. Bowie, D. and G.D. Lange

Functional stoichiometry of glutamate receptor desensitization.

The Journal of Neuroscience. 2002

9. Bowie, D.

External anions and cations distinguish between AMPA and kainate receptor gating mechanisms.

The Journal of Physiology. 2002

8. Banke, T.G., Bowie, D. Lee, H.-K., Huganir, R., Schousboe, A. and Traynelis, S.F.

Control of GluR1 AMPA receptor function by cAMP-dependent protein kinase.

The Journal of Neuroscience. 2000

7. Bowie, D., Bähring, R. and Mayer, M.L.

Block of AMPA and Kainate Receptors by Polyamines and Arthropod Toxins.

Handbook of Experimental Pharmacology, Ionotropic Glutamate Receptors in the CNS. Edited by P. Jonas and H. Monyer, Chapter 7, 251-373. 1999

6. Dingledine, R., Borges, K., Bowie, D. and Traynelis S.

The Glutamate Receptor Ion Channels

Pharmacological Reviews. 1999

5. Bowie, D., Lange, G.D. and Mayer, M.L.

Activity-dependent modulation of glutamate receptors by polyamines.

The Journal of Neuroscience. 1998

4. Bähring, R., Bowie, D., Benveniste, M. and Mayer, M.L.

Permeation and block of rat GluR6 glutamate receptor channels by internal and external polyamines.

The Journal of Physiology. 1997

3. Mayer, M.L., Partin, K.M., Patneau, Wong, L.A., Vyklicky, L. Jr., Benveniste, M.J. and Bowie, D.

Desensitization at AMPA, Kainate and NMDA receptors.

"Excitatory Amino Acids and Synaptic Function", 2nd Ed. H. Wheal and A. Thomson, pp 89-98. Academic Press. 1995

2. Bowie, D. and Mayer, M.L.

Inward rectification of both AMPA and Kainate subtype Glutamate receptors generated by polyamine mediated ion channel block.

Neuron. 1995

1. Partin, K.M., Bowie, D. and Mayer, M.L.

Structural determinants of allosteric modulation in alternatively spliced AMPA receptors.

Neuron. 1995