Publications
(since 1995)
72. Federico Miguez-Cabello, Xin-tong Wang, Yuhao Yan, Niklas Brake, Ryan P. D. Alexander. Amanda M. Perozzo, Anmar Khadra, and Derek Bowie. GluA2-containing AMPA receptors form a continuum of Ca2+-permeable channels. |
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71. Silke Buschbom-Helmke, Pengfei Wang, Anna Alcaide, Federico Miguez-Cabello, Mario Carta, Julio S. Viotti, Birgitte Nielsen, Christophe Mulle, Derek Bowie, Flemming Steen Jørgensen, Darryl S. Pickering, Lennart Bunch. Domoic Acid as a Lead for the Discovery of the First Selective Ligand for Kainate Receptor Subtype 5 (GluK5). |
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70. Yasmine Bay, Federico Javier Miguez-Cabello, Chloe C. Koens, Stine M. Fransten, Daryl S. Pickering, Karla Frydenvang, Pierre Francotte, Bernard Pirotte, Anders S. Kristensen, Derek Bowie, Jette Sandholm Kastrup. Crystal structure of the GluK1 ligand-binding domain with kainate and the full-spannnig positive allosteric modulator BPAM538. |
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69. Terunaga Nakagawa, Xin-tong Wang, Federico J. Miguez-Cabello, and Derek Bowie The open gate of the AMPA receptor forms a Ca2+ binding site critical in regulating ion transport. |
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68. Andreas Haahr Larsen, Amanda M. Perozzo, Philip C. Biggin, Derek Bowie, and Jette Sandholm Kastrup Recovery from desensitization in GluA2 AMPA receptors is affected by a single mutation in the N-terminal domain interface. |
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67. Amanda M Perozzo, Jochen Schwenk, Aichurok Kamalova, Terunaga Nakagawa, Bernd Fakler, and Derek Bowie GSG1L-containing AMPA receptor complexes are defined by their spatiotemporal expression, native interactome and allosteric sites. |
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66. Amanda M Perozzo, Patricia MGE Brown, and Derek Bowie Alternative splicing of the flip/flop cassette and TARP auxiliary subunits engage in a privileged relationship that fine-tunes AMPA receptor gating. |
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65. Saviuk N, Chong Y, Wang P, Bermudez S, Zhao Z, Bhaskaran AA, Bowie D, Sonenberg N, Cooper E, Haghighi AP Loss of 4E-BP converts cerebellar long-term depression to long-term potentiation. |
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64. Niklas Brake, Adamo S. Mancino, Yuhao Yan, Takushi Shimomura, Yoshihiro Kubo, Anmar Khadra, Derek Bowie Closed-state inactivation of cardiac, skeletal, and neuronal sodium channels is isoform specific. |
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63. Adamo S. Mancino, William G. Glass, Yuhao Yan, Philip C. Biggin, Derek Bowie Splice variants of Nav1.5 alter activation by distinct mechanisms. |
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62. Derek Bowie The many faces of the AMPA-type ionotropic glutamate receptor. Special Issue on Glutamate Receptors – AMPA receptors |
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61. David J.A. Wyllie and Derek Bowie Ionotropic glutamate receptors:structure, function and dysfunction. |
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60. Kasper B. Hansen, Lonnie P. Wollmuth, Derek Bowie, Hiro Furukawa, Frank S. Menniti, Alexander I. Sobolevsky, Geoffrey T. Swanson, Sharon A. Swanger, Ingo H. Greger, Terunaga Nakagawa, Chris J. McBain, Vasanthi Jayaraman, Chian-Ming Low, Mark L. Dell’Acqua, Jeffrey S. Diamond, Chad R. Camp, Riley E. Perszyk, Hongjie Yuan and Stephen F. Traynelis Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels. |
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59. Nandish Khanra, Patricia MGE Brown, Amanda M Perozzo, Derek Bowie and Joel Meyerson Architecture and structural dynamics of the heteromeric GluK2/K5 kainate receptor. |
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58. Bowie D. Neurotransmitter-gated ion channels, still front and centre stage. |
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57. Saeed Farjami, Ryan P.D. Alexander, Derek Bowie and Anmar Khadra Bursting in Cerebellar Stellate Cells Induced by Pharmacological Agents: Non-sequential Spike Adding |
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56. Ryan P.D. Alexander and Derek Bowie Intrinsic plasticity of cerebellar stellate cells is mediated by NMDA receptor regulation of voltage‐gated Na+ channels Selected as Editor's Choice in the 15 January 2021 Issue (Volume 599 Number 2)! |
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55. G. Brent Dawe, Patricia M.G.E. Brown and Derek Bowie AMPA and Kainate Receptors |
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54. Erik Larson, Michael Accardi, Ying Wang, Martina D'Antoni, Benyamin Karimi, Tabrez Siddiqui and Derek Bowie Nitric oxide signaling strengthens inhibitory synapses of cerebellar molecular layer interneurons through a GABARAP-dependent mechanism |
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53. Saeed Farjami, Ryan P.D. Alexander, Derek Bowie and Anmar Khadra Switching in Cerebellar Stellate Cell Excitability in Response to a Pair of Inhibitory/Excitatory Presynaptic Inputs: A Dynamical System Perspective |
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52. John Mitry, Ryan P.D. Alexander, Saeed Farjami, Derek Bowie and Anmar Khadra Modeling excitability in cerebellar stellate cells: Temporal changes in threshold, latency and frequency of firing |
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51. Ryan P.D. Alexander, John Mitry, Vasu Sareen, Anmar Khadra and Derek Bowie Cerebellar stellate cell excitability is coordinated by shifts in the gating behavior of voltage-gated Na+ and A-type K+ channels |
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50. G. Brent Dawe, Md. Fahim Kadir, Raminta Venskutonyte, Amanda M. Perozzo, Yuhao Yan, Ryan P.D. Alexander, Camilo Navarrete, Eduardo A. Santander, Marika Arsenault, Christian Fuentes, Mark R.P. Aurousseau, Karla Frydenvang, Nelson P. Barrera, Jette S. Kastrup, J. Michael Edwardson, and Derek Bowie. Nanoscale Mobility of the Apo State and TARP Stoichiometry Dictate the Gating Behavior of Alternatively Spliced AMPA Receptors. |
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49. Bowie D. Polyamine-mediated channel block of ionotropic glutamate receptors and its
regulation by auxiliary proteins. |
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48. Bowie D. Shared and unique aspects of ligand- and voltage-gated ion-channel
gating. |
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47. Brown PMGE, McGuire H, Bowie D. Stargazin and cornichon-3 relieve polyamine block of AMPA receptors by enhancing blocker permeation. |
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46. Paramo T, Brown PMGE, Musgaard M, Bowie D, Biggin PC. Functional Validation of Heteromeric Kainate Receptor Models. |
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45. Liebsch F, Aurousseau MRP, Bethge T, McGuire H, Scolari S, Herrmann A, Blunck R, Bowie D, Multhaup G. Full-length Cellular Beta-secretase Has a Trimeric Subunit Stoichiometry, and Its Sulfur-rich Transmembrane Interaction Site Modulates Cytosolic Copper Compartmentalization. |
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44. Krogsgaard-Larsen N, Delgar CG, Koch K, Brown PM, Møller C, Han L, Huynh TH, Hansen SW, Nielsen B, Bowie D, Pickering DS, Kastrup JS, Frydenvang K, Bunch L. Design and Synthesis of a Series of l-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic Acid. |
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43. G. Brent Dawe, Maria Musgaard, Mark R.P. Aurousseau, Naushaba Nayeem, Tim Green, Philip C. Biggin, Derek Bowie. Distinct Structural Pathways Coordinate the Activation of AMPA Receptor-Auxiliary Subunit Complexes. |
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42. Brown PM, Aurousseau MR, Musgaard M, Biggin PC, Bowie D. Kainate receptor pore-forming and auxiliary subunits regulate channel block by a novel mechanism. |
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41. Aurousseau MRP, McGuire H, Blunck R and Bowie D. Ionotropic Glutamate Receptor Technologies |
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40. Jorge L. Cueva Vargas, Ingrid K. Osswald, Nicolas Unsain, Mark R. Aurousseau, Philip A. Barker, Derek Bowie and Adriana Di Polo. Soluble Tumor Necrosis Factor Alpha Promotes Retinal Ganglion Cell Death in Glaucoma via Calcium-Permeable AMPA Receptor Activation. |
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39. Bowie D, Attwell D. Coupling cellular metabolism to neuronal signalling. |
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38. Accardi MV, Brown PMGE, Miraucourt LS, Orser BA, Bowie D. α6-Containing GABAA Receptors Are the Principal Mediators of Inhibitory Synapse Strengthening by Insulin in Cerebellar Granule Cells. |
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37. Paolo Schiavini, G. Brent Dawe, Derek Bowie, Nicolas Moitessier Discovery of novel small-molecule antagonists for GluK2 |
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36. Demmer CS, Møller C, Brown PM, Han L, Pickering DS, Nielsen B, Bowie D, Frydenvang K, Kastrup JS, Bunch L. Binding Mode of an α-Amino Acid-Linked Quinoxaline-2,3-dione Analogue at Glutamate Receptor Subtype GluK1. |
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35. Bowie D. Ionotropic glutamate receptors: alive and kicking |
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34. Bowie D. Ionotropic glutamate receptors made crystal clear |
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33. Dawe GB, Aurousseau MR, Daniels BA, Bowie D. Retour Aux Sources: Defining the structural basis of glutamate receptor activation. |
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32. Penna A, Wang DS, Yu J, Lecker I, Brown PM, Bowie D, Orser BA Hydrogen Peroxide Increases GABAA Receptor-Mediated Tonic Current in Hippocampal Neurons. |
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31. Accardi MV, Daniels BA, Brown PM, Fritschy JM, Tyagarajan SK, Bowie D. Mitochondrial reactive oxygen species regulate the strength of inhibitory GABA-mediated synaptic transmission. |
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30. Dawe GB, Musgaard M, Andrews ED, Daniels BA, Aurousseau MR, Biggin PC, Bowie D. Defining the structural relationship between kainate-receptor deactivation and desensitization. |
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29. Daniels BA, Andrews ED, Aurousseau MR, Accardi MV, Bowie D. Crosslinking the ligand-binding domain dimer interface locks kainate receptors out of the main open state. |
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28. Hugo McGuire*, Mark R. P. Aurousseau*, Derek Bowie, and Rikard Blunck Automating single subunit counting of membrane proteins in mammalian cells |
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27. Aurousseau, M.R.P., Osswald, I.K. and Bowie, D. Thinking of Co2+-staining explant tissue or cultured cells? How to make it reliable and specific. |
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26. Bowie, D. Ligand-gated ion channels: From genes to behaviour. |
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25. Bowie, D. Redefining the classification of AMPA-selective ionotropic glutamate receptors. |
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24. Maclean,D.M., and Bowie,D. Transmembrane AMPA receptor regulatory protein regulation of competitive antagonism: a problem of interpretation |
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23. Lachance-Touchette, P.*, Brown, P.*, Meloche, C., Kinirons, P., Lapointe, L., Lortie, A., Carmant, L., Bedford, F., Bowie, D. & Cossette, P. Novel α1 and γ2 GABAA receptor mutations in families with idiopathic generalized epilepsy. *Both authors contributed equally to this work. |
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22. D. M. MacLean, A. Y. C. Wong, A-M. Fay, and D. Bowie Cations But Not Anions Regulate the Responsiveness of Kainate Receptors |
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21. Bowie, D. and McKinney, R.A. Neurophysiology of inhibitory and excitatory amino acid receptors |
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20. Bowie, D. Ion-dependent gating of kainate receptors |
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19. Lebrun-Julien, F., Duplan, L., Pernet, V., Osswald, I.K., Sapieha, P., Bourgeois, P., Dickson, K.M., Bowie, D., Barker, P. and Di Polo, A. Excitotoxic death of retinal neurons in vivo occurs via a non-cell-autonomous mechanism |
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18. Fay, A-M., Corbeil, C., Brown, P., Moitessier, N. and Bowie, D. Functional characterisation and in silicodocking of full and partial agonists acting on GluK2 kainate receptors |
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17. Zhao, B., Wong, A.Y., Murshid, A., Bowie, D., Presley, J.F. and Bedford, F.K. Identification of a novel di-leucine motif mediating K(+)/Cl(-) cotransporter KCC2 constitutive endocytosis |
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16. Bowie, D. Ionotropic Glutamate Receptors and CNS Disorders |
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15. Wong, A.Y.C., MacLean, D.M. and Bowie, D. Na+ / Cl- dipole couples agonist binding to kainate receptor activation |
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14. Osswald, I.K., Galan, A. and Bowie, D. Light triggers expression of philanthotoxin-insensitive Ca2+-permeable AMPA receptors in the developing rat retina |
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13. Wong, A.Y.C., Fay, A-M, and Bowie, D. External ions are co-activators of kainate receptors |
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12. Fay, A-M, and Bowie, D. Concanavalin-A reports agonist-induced conformational changes in the intact GluR6 kainate receptor |
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11. Bowie, D., Garcia, E.P., Marshall, J, Traynelis, S.F. and Lange, G.D. Allosteric regulation and spatial distribution of kainate receptors bound to ancillary proteins. |
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10. Bowie, D. and G.D. Lange Functional stoichiometry of glutamate receptor desensitization. |
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9. Bowie, D. External anions and cations distinguish between AMPA and kainate receptor gating mechanisms. |
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8. Banke, T.G., Bowie, D. Lee, H.-K., Huganir, R., Schousboe, A. and Traynelis, S.F. Control of GluR1 AMPA receptor function by cAMP-dependent protein kinase. |
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7. Bowie, D., Bähring, R. and Mayer, M.L. Block of AMPA and Kainate Receptors by Polyamines and Arthropod Toxins. |
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6. Dingledine, R., Borges, K., Bowie, D. and Traynelis S. The Glutamate Receptor Ion Channels |
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5. Bowie, D., Lange, G.D. and Mayer, M.L. Activity-dependent modulation of glutamate receptors by polyamines. |
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4. Bähring, R., Bowie, D., Benveniste, M. and Mayer, M.L. Permeation and block of rat GluR6 glutamate receptor channels by internal and external polyamines. |
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3. Mayer, M.L., Partin, K.M., Patneau, Wong, L.A., Vyklicky, L. Jr., Benveniste, M.J. and Bowie, D. Desensitization at AMPA, Kainate and NMDA receptors. |
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2. Bowie, D. and Mayer, M.L. Inward rectification of both AMPA and Kainate subtype Glutamate receptors generated by polyamine mediated ion channel block. |
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1. Partin, K.M., Bowie, D. and Mayer, M.L. Structural determinants of allosteric modulation in alternatively spliced AMPA receptors. |
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