Laboratory of Cellular and Molecular Neuroscience

Research Interests

The Bowie Lab uses a combination of techniques to study ionotropic glutamate receptors (iGluRs), GABA-A receptors and more recently, Na+ channels. All ion-channel families are widespread in the vertebrate brain and fulfill many important roles in healthy individuals as well as being implicated in disease states associated with postnatal development (e.g. Autism, Schizophrenia), cerebral insult (e.g. Stroke, Epilepsy) and aging disorders (e.g. Alzheimer's disease, Parkinsonism). We are looking at iGluRs, GABA-A receptors and Na+ channels at two inter-related levels. In molecular terms, we are examining the events that occur when each ion-channel family is activated with the aim of developing novel therapeutic compounds. At the cellular level, we are studying the role that iGluRs, GABA-A receptors and Na+ channels fulfill in shaping the behaviour of neuronal circuits and how these processes may be corrected in disease states.

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Lab news

October 2018 - Dr. Bowie and Dr. Keith Murai led a delegation of McGill professors and 2 McGill students to the National Institute of Physiological Sciences (NiPS) in Okazaki, Japan to start the next phase of the McGill-NiPS partnership. (see photos)

Dr. Bowie was also invited by Dr. Chen-Tung Yen to present two talks on the lab's research work during visits to the Academia Sinica and the National Taiwan University (NTU), which are both situated in Taipei, Taiwan. Dr. Bowie was also taken on a cultural trip to the National Palace Museum and Hu Shih Memorial Hall. (see photos)

September 2018 - Welcome to our new rotation students, Rebecca Cummers and Niklas Brake, who will work on the structure of AMPA receptors and biology of sodium channels, respectively. See their photos and biographies here.

Many congrats to PhD student, Ryan Alexander, who is the recipient of the 2018 Life Sciences Award for his poster presentation at Pharmacology Research Day.

Congratulations to MSc student, Amanda Perozzo, who was awarded the J.P. Collip Fellowship 2018-2019 from the Faculty of Medicine. Well done, Amanda!

The program for the 2018-2019 MNG has been posted.

Join the lab

We currently have positions available for graduate students and/or post-doctoral fellows. Click the link above for more information!

Find out more about us by looking us up on the NeuroTree