Laboratory of Cellular and Molecular Neuroscience

Research Interests

The Bowie Lab uses a combination of techniques to study ionotropic glutamate receptors (iGluRs), GABA-A receptors and more recently, Na+ channels. All ion-channel families are widespread in the vertebrate brain and fulfill many important roles in healthy individuals as well as being implicated in disease states associated with postnatal development (e.g. Autism, Schizophrenia), cerebral insult (e.g. Stroke, Epilepsy) and aging disorders (e.g. Alzheimer's disease, Parkinsonism). We are looking at iGluRs, GABA-A receptors and Na+ channels at two inter-related levels. In molecular terms, we are examining the events that occur when each ion-channel family is activated with the aim of developing novel therapeutic compounds. At the cellular level, we are studying the role that iGluRs, GABA-A receptors and Na+ channels fulfill in shaping the behaviour of neuronal circuits and how these processes may be corrected in disease states.

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Lab news

May 2019 - Ryan presented his Thesis Seminar, completing one of his final PhD milestones. Well done!

Congrats to Amanda for successful completion of her Candidacy Exam/Transfer to PhD!

The Bowie Lab attended the Canadian Association for Neuroscience (CAN) 2019 Meeting in Toronto. See how they enjoyed great food and science here.

Congrats to PhD student Ryan for his first author manuscript published at eNeuro. We are proud of you Ryan! Check out the full article.

We said goodbye to visiting student Kathrine and undergraduate student Tian with lunch at McGill's Thompson House. See our farewell photo here!

April 2019 - Congrats to Bowie lab members for their recent publication in Neuron! The multi-disciplinary and international study was performed in collaboration with the labs of Dr. Mike Edwardson (Cambridge University), Jette Kastrup (University of Copenhagen) and Nelson Barrera (Catholic University of Chile). See publications.

The website for the 7th Annual iGluRetreat (30-31st July 2019) and ISN Satellite Meeting (1st-2nd Aug 2019) was recently launched. These two conferences will be held this summer in Montreal. Peruse the website to see a list of speakers and registration details!

Many congrats to Amanda for being awarded a prestigious 3-year NSERC doctoral fellowship for her PhD thesis work. Well done!

Join the lab

We currently have positions available for graduate students and/or post-doctoral fellows. Click the link above for more information!

Find out more about us by looking us up on the NeuroTree

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