Laboratory of Cellular and Molecular Neuroscience

Research Interests

The Bowie Lab uses a combination of techniques to study ionotropic glutamate receptors (iGluRs), GABA-A receptors and more recently, Na+ channels. All ion-channel families are widespread in the vertebrate brain and fulfill many important roles in healthy individuals as well as being implicated in disease states associated with postnatal development (e.g. Autism, Schizophrenia), cerebral insult (e.g. Stroke, Epilepsy) and aging disorders (e.g. Alzheimer's disease, Parkinsonism). We are looking at iGluRs, GABA-A receptors and Na+ channels at two inter-related levels. In molecular terms, we are examining the events that occur when each ion-channel family is activated with the aim of developing novel therapeutic compounds. At the cellular level, we are studying the role that iGluRs, GABA-A receptors and Na+ channels fulfill in shaping the behaviour of neuronal circuits and how these processes may be corrected in disease states.

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Lab news

August 2022 - The Bowie lab - represented by Derek, Amanda, Fede, and Zhe - attended the 8th Annual iGluRetreat in Stony Brook, NY. Take a look at the program and photos!

July 2022 - Overcome SYNGAP1, Wandoan Campdraft for a Cure & SynGAP Research Fund have just announced a $150,000 grant for small molecule translational research to Dr. Derek Bowie! Check out the press release.

June 2022 - Dr. Bowie travelled to the UK to attend the Ion Channel Modulation Symposium hosted by Sophion Bioscience.

May 2022 - The Bowie lab has been busy (finally) attending in-person conferences once again, including the Canadian Association for Neuroscience (CAN) Meeting in Toronto and the International Union of Pure and Applied Biophysics (IUPAB) Focused Meeting on LGICs in Ottawa. See photos here.

Congrats to PhD student Niklas and former MSc students Adamo and Edward for their publication in JGP on the biophysical properties of sodium channels!

Join the lab

We currently have positions available for graduate students and/or post-doctoral fellows. Click the link above for more information!

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