Laboratory of Cellular and Molecular Neuroscience

Research Interests

The Bowie Lab uses a combination of techniques to study ionotropic glutamate receptors (iGluRs), GABA-A receptors and more recently, Na+ channels. All ion-channel families are widespread in the vertebrate brain and fulfill many important roles in healthy individuals as well as being implicated in disease states associated with postnatal development (e.g. Autism, Schizophrenia), cerebral insult (e.g. Stroke, Epilepsy) and aging disorders (e.g. Alzheimer's disease, Parkinsonism). We are looking at iGluRs, GABA-A receptors and Na+ channels at two inter-related levels. In molecular terms, we are examining the events that occur when each ion-channel family is activated with the aim of developing novel therapeutic compounds. At the cellular level, we are studying the role that iGluRs, GABA-A receptors and Na+ channels fulfill in shaping the behaviour of neuronal circuits and how these processes may be corrected in disease states.

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Lab news

April 2019 - The website for the 7th Annual iGluRetreat (30-31st July 2019) and ISN Satellite Meeting (1st-2nd Aug 2019) was recently launched. These two conferences will be held this summer in Montreal. Peruse the website to see a list of speakers and registration details!

Many congrats to Amanda for being awarded a prestigious 3-year NSERC doctoral fellowship for her PhD thesis work. Well done!

March 2019 - Dr. Bowie travelled with NEURO colleagues, Drs. Ted Fon (middle) and Stefano Stifano (left), as the McGill delegation that visited the Neuroscience faculty at the University of Edinburgh in Scotland. The groups photo shows Edinburgh’s Drs. David Wyllie (right) and Siddarthan Chandran (3rd from right) with the University Principal and Vice-Chancellor, Dr. Peter Mathieson (2nd from left), at the signing ceremony with Derek, Ted and Stefano. The group were also treated to a traditional breakfast fry-up with black pudding and haggis with an evening of some whisky tasting and dinner at Edinburgh’s Scotch Malt Whisky Society (www.smws.com).

January 2019 - Congrats to the Bowie lab for renewing their CIHR grant entitled "Unravelling the complex roles of AMPA receptor auxiliary subunits in the mammalian brain" which will provide funding to the lab for the next five years!

Join the lab

We currently have positions available for graduate students and/or post-doctoral fellows. Click the link above for more information!

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