Laboratory of Cellular and Molecular Neuroscience
Synaptic Activity in AII Amacrine Cells
iGluR Structures
Antibody Staining of the Rat Retina
GABA Receptor Structure
iGluR Single Channels
NaV-Ab Structure
Spikes in cerebellar stellate cells
iGluR Drug Discovery
GABA Receptors in Human Epilepsy
AMPARs in Glaucoma
Sodium Currents
Single Channel iGluRs
AMPAR Signaling Complex
Research Interests
The Bowie Lab uses a combination of techniques to study ionotropic glutamate receptors (iGluRs), GABA-A receptors and more recently, Na+ channels. All ion-channel families are widespread in the vertebrate brain and fulfill many important roles in healthy individuals as well as being implicated in disease states associated with postnatal development (e.g. Autism, Schizophrenia), cerebral insult (e.g. Stroke, Epilepsy) and aging disorders (e.g. Alzheimer's disease, Parkinsonism). We are looking at iGluRs, GABA-A receptors and Na+ channels at two inter-related levels. In molecular terms, we are examining the events that occur when each ion-channel family is activated with the aim of developing novel therapeutic compounds. At the cellular level, we are studying the role that iGluRs, GABA-A receptors and Na+ channels fulfill in shaping the behaviour of neuronal circuits and how these processes may be corrected in disease states.
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Important Links
Lab news
October 2025 - Congratulations to Fede and Xin-tong on their great presentations at iGluRetreat. Hard work pays off!
Cecilia and Chloe opened the Molecular Neuroscience Group (MNG) seminar series for the 2025 - 2026 academic year with captivating presentations showcasing their latest research.
Congratulations to Chloe, who ran her first marathon in Quebec City!
July 2025 - Welcome to the lab, Javier Picañol! We're thrilled to have you join us as a visiting student from the University of Barcelona.
Congratulations to Chloe and Fede for the publication of their recent collaboration with Dr. Adriano Senatore. Team work makes the dream work!
June 2025 - The Bowie lab is excited to welcome CEGEP students Emeline Tchung and Sylia Amara, who will be joining us for a 10-week research internship.
April 2025 - The lab welcomes new PhD rotation student, Liam Clancy. Looking forward to working with you Liam!
The Bowie lab is making waves with our latest publication in Nature! Don't miss our interview with La Presse.
Join the lab
We currently have positions available for graduate students and/or post-doctoral fellows. Click the link above for more information!
Find out more about us by looking us up on the NeuroTree