Laboratory of Cellular and Molecular Neuroscience

Research Interests

The Bowie Lab uses a combination of techniques to study ionotropic glutamate receptors (iGluRs), GABA-A receptors and more recently, Na+ channels. All ion-channel families are widespread in the vertebrate brain and fulfill many important roles in healthy individuals as well as being implicated in disease states associated with postnatal development (e.g. Autism, Schizophrenia), cerebral insult (e.g. Stroke, Epilepsy) and aging disorders (e.g. Alzheimer's disease, Parkinsonism). We are looking at iGluRs, GABA-A receptors and Na+ channels at two inter-related levels. In molecular terms, we are examining the events that occur when each ion-channel family is activated with the aim of developing novel therapeutic compounds. At the cellular level, we are studying the role that iGluRs, GABA-A receptors and Na+ channels fulfill in shaping the behaviour of neuronal circuits and how these processes may be corrected in disease states.

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Lab news

September 2017 - Dr. Bowie recently hosted a delegation of researchers from Japan's National Institute of Physiological Sciences (NiPS) who spent two days visiting the McGill campus and participating in a research symposium at McGill's Faculty Club. The visit culminated in the signing of a Memorandum Of Understanding (MOU) (see photo) in the presence of Mr. Hideaki Kuramitsu, the Consulate General of Japan in Montreal. The MOU permits the neuroscience communities of McGill and NiPS to begin the exchange of student and postdoctoral fellows as well as to establish joint research projects. The event was reported in the McGill Reporter (http://publications.mcgill.ca/reporter/2017/10/mcgill-signs-mou-with-leading-japanese-research-institute/).

August 2017 - Photo of some of the attendees at the 2017 GEPROM Summer Student Symposium, including Amanda Perozzo, that was held at McGill on August 18th. See photo.

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