Laboratory of Cellular and Molecular Neuroscience
Synaptic Activity in AII Amacrine Cells
iGluR Structures
Antibody Staining of the Rat Retina
GABA Receptor Structure
iGluR Single Channels
NaV-Ab Structure
Spikes in cerebellar stellate cells
iGluR Drug Discovery
GABA Receptors in Human Epilepsy
AMPARs in Glaucoma
Sodium Currents
Single Channel iGluRs
AMPAR Signaling Complex
Research Interests
The Bowie Lab uses a combination of techniques to study ionotropic glutamate receptors (iGluRs), GABA-A receptors and more recently, Na+ channels. All ion-channel families are widespread in the vertebrate brain and fulfill many important roles in healthy individuals as well as being implicated in disease states associated with postnatal development (e.g. Autism, Schizophrenia), cerebral insult (e.g. Stroke, Epilepsy) and aging disorders (e.g. Alzheimer's disease, Parkinsonism). We are looking at iGluRs, GABA-A receptors and Na+ channels at two inter-related levels. In molecular terms, we are examining the events that occur when each ion-channel family is activated with the aim of developing novel therapeutic compounds. At the cellular level, we are studying the role that iGluRs, GABA-A receptors and Na+ channels fulfill in shaping the behaviour of neuronal circuits and how these processes may be corrected in disease states.
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Important Links
Lab news
May 2023 - Zhe attended the Healthy Brains Healthy Lives (HBHL) Symposium and was awarded a prize for the best poster presentation for Theme 3: Applied Cognitive Neuroscience of Brain Plasticity. We are proud of you, Zhe!
The lab welcomes IPN Rotation student, Sapphire Hou, for the next 3 months.
April 2023 - Nils was awarded an NSERC PGSD fellowship. Well done, Nils!
March 2023 - Congrats to Amanda on her first, first author publication which was accepted this month in the Journal of Neuroscience. Read the full article here.
Kudos to senior PhD Candidate Amanda who successfully completed her Thesis Seminar. Another milestone closer to the finish line!
January 2023 - Happy New Year! The Molecular Neuroscience Group (MNG) continues to meet. The schedule is updated regularly here.
Join the lab
We currently have positions available for graduate students and/or post-doctoral fellows. Click the link above for more information!
Find out more about us by looking us up on the NeuroTree