Laboratory of Cellular and Molecular Neuroscience
The Bowie Lab uses a combination of techniques to study ionotropic glutamate receptors (iGluRs), GABA-A receptors and more recently, Na+ channels. All ion-channel families are widespread in the vertebrate brain and fulfill many important roles in healthy individuals as well as being implicated in disease states associated with postnatal development (e.g. Autism, Schizophrenia), cerebral insult (e.g. Stroke, Epilepsy) and aging disorders (e.g. Alzheimer's disease, Parkinsonism). We are looking at iGluRs, GABA-A receptors and Na+ channels at two inter-related levels. In molecular terms, we are examining the events that occur when each ion-channel family is activated with the aim of developing novel therapeutic compounds. At the cellular level, we are studying the role that iGluRs, GABA-A receptors and Na+ channels fulfill in shaping the behaviour of neuronal circuits and how these processes may be corrected in disease states.
More About Us...
January 2019 - Congrats to the Bowie lab for renewing their CIHR grant entitled "Unravelling the complex roles of AMPA receptor auxiliary subunits in the mammalian brain" which will provide funding to the lab for the next five years!
Welcome to two new students who joined the lab in the New Year. PhD student, Sara Deschaine, joins us from the National Institutes of Health in the US and Masters student, Kathrine Voigt Hansen, joins us from the University of Copenhagen in Denmark. Kathrine is currently carrying out a 4-month research project through a collaboration with Drs. Jette Kastrup and Darryl Pickering. Sara will be working on the neurophysiology of the cerebellum in Fragile X syndrome.
October 2018 - Dr. Bowie and Dr. Keith Murai led a delegation of McGill professors and 2 McGill students to the National Institute of Physiological Sciences (NiPS) in Okazaki, Japan to start the next phase of the McGill-NiPS partnership. (see photos)
Dr. Bowie was also invited by Dr. Chen-Tung Yen to present two talks on the lab's research work during visits to the Academia Sinica and the National Taiwan University (NTU), which are both situated in Taipei, Taiwan. Dr. Bowie was also taken on a cultural trip to the National Palace Museum and Hu Shih Memorial Hall. (see photos)