posted: November 1st, 2017
Laboratory of Cellular And Molecular Neuroscience
Graduate Student/Postdoctoral Positions in Receptor Pharmacology
CIHR-funded position is immediately available for an enthusiastic graduate student and/or postdoctoral fellow with a keen interest in using electrophysiology and imaging techniques to study ligand-gated ion-channels and their role in neuronal circuit behavior. The position and training provided is ideal for an individual interested in pursuing a career in academia and/or the pharmaceutical drug industry.
The project will focus on an ongoing theme to understand the structure-function properties of ionotropic glutamate receptors. The successful applicant will use single-molecule and macroscopic electrophysiology and imaging techniques to understand the mechanism of channel activation in wildtype and mutant receptors. This work is part of a multi-lab project with international collaborators using computational chemistry, structural biology and advanced microscopy techniques.
- Dawe et al (2016) Distinct structural pathways coordinate the activation of AMPA receptor-auxiliary subunit complexes. Neuron. 89(6):1264-1276
- Brown et al (2016) Kainate receptor pore-forming and auxiliary subunits regulate channel block by a novel mechanism. J Physiol. 2016 Apr 1;594(7):1821-40.
- Dawe et al (2013) Defining the structural relationship between kainate-receptor deactivation and desensitization. Nat Struct Mol Biol. 2013 Sep;20(9):1054-61.
*Student stipends will be based on the policy recommendations of individual McGill Graduate Programs. Postdoctoral salaries will be based on CIHR recommendations and level of experience*
Applicants should send a cover letter, CV and the names of 2-3 referees to:
Dr. Derek Bowie
Department of Pharmacology & Therapeutics
McGill University, Faculty of Medicine
3649 Promenade Sir-William Osler, Rm 164
Montreal, QC, Canada, H3G 0B1
Tele: 514-398-1581 Email:firstname.lastname@example.org
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