Laboratory of Cellular and Molecular Neuroscience
The Bowie Lab uses a combination of techniques to study ionotropic glutamate receptors (iGluRs) and more recently, GABA-A receptors. Both receptor families are widespread in the vertebrate brain and fulfill many important roles in healthy individuals as well as being implicated in disease states associated with postnatal development (e.g. Autism, Schizophrenia), cerebral insult (e.g. Stroke, Epilepsy) and aging disorders (e.g. Alzheimer's disease, Parkinsonism). We are looking at iGluRs and GABA-A receptors at two inter-related levels. In molecular terms, we are examining the events that occur when both receptor families are activated with the aim of developing novel therapeutic compounds. At the cellular level, we are studying the role that iGluRs and GABA-A receptors fulfill in shaping the behaviour of neuronal circuits and how these processes may be corrected in disease states.
More About Us...
Join the lab
We currently have positions available for graduate students and/or post-doctoral fellows. Click the link for more information!
Find out more about us by looking us up on the NeuroTree.
August 2013 - Brent and Dr. Bowie attend the Benzon symposium in Copenhagen
August 2013 - Brent Dawe et al publish in Nature Structural and Molecular Biology! Congratulations! Follow the link!
Last updated: 11-SEPT-2013 10:00AM
Research & Focus
There are several ongoing projects in our lab. Our main interests include ionotropic glutamate receptors, as well as GABAA receptors. Follow this link to find out more about our research.