Laboratory of Cellular and Molecular Neuroscience
The Bowie Lab uses a combination of techniques to study ionotropic glutamate receptors (iGluRs), GABA-A receptors and more recently, Na+ channels. All ion-channel families are widespread in the vertebrate brain and fulfill many important roles in healthy individuals as well as being implicated in disease states associated with postnatal development (e.g. Autism, Schizophrenia), cerebral insult (e.g. Stroke, Epilepsy) and aging disorders (e.g. Alzheimer's disease, Parkinsonism). We are looking at iGluRs, GABA-A receptors and Na+ channels at two inter-related levels. In molecular terms, we are examining the events that occur when each ion-channel family is activated with the aim of developing novel therapeutic compounds. At the cellular level, we are studying the role that iGluRs, GABA-A receptors and Na+ channels fulfill in shaping the behaviour of neuronal circuits and how these processes may be corrected in disease states.
More About Us...
September 2015 - Congrats to Dr. David MacLean, Bowie lab alumni, who was recently awarded a K99 research grant to initiate his research program as an independent investigator at the University of Texas (see link).
September 2015 - The 2015-2106 MNG schedule has been published (see link).
September 2015 - SAVE THE DATE!!!! Bowie lab to host the 2016 Glutamate Receptor Retreat in Montreal (August, 2nd-4th). See link.