Laboratory of Cellular and Molecular Neuroscience
Synaptic Activity in AII Amacrine Cells
iGluR Structures
Antibody Staining of the Rat Retina
GABA Receptor Structure
iGluR Single Channels
NaV-Ab Structure
Spikes in cerebellar stellate cells
iGluR Drug Discovery
GABA Receptors in Human Epilepsy
AMPARs in Glaucoma
Sodium Currents
Single Channel iGluRs
AMPAR Signaling Complex
Research Interests
The Bowie Lab uses a combination of techniques to study ionotropic glutamate receptors (iGluRs), GABA-A receptors and more recently, Na+ channels. All ion-channel families are widespread in the vertebrate brain and fulfill many important roles in healthy individuals as well as being implicated in disease states associated with postnatal development (e.g. Autism, Schizophrenia), cerebral insult (e.g. Stroke, Epilepsy) and aging disorders (e.g. Alzheimer's disease, Parkinsonism). We are looking at iGluRs, GABA-A receptors and Na+ channels at two inter-related levels. In molecular terms, we are examining the events that occur when each ion-channel family is activated with the aim of developing novel therapeutic compounds. At the cellular level, we are studying the role that iGluRs, GABA-A receptors and Na+ channels fulfill in shaping the behaviour of neuronal circuits and how these processes may be corrected in disease states.
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Important Links
Lab news
September 2024 - The lab welcomes a new PhD student, Nilesh Shah.
Congrats to Zhe and Chloe for their recent presentations at the MNG seminar series!
The lab attends the annual IPN retreat, where Xin-tong, Zhe, Fede, and Chloe presented posters and had the opportunity to connect with others in the program.
August 2024 - The lab recently attended the annual iGluRetreat in Toronto, ON.
Congratulations to Chloe and Zhe for each recieving the Integrated Program in Neuroscience Internal Award. Keep up the good work!
The lab warmly welcomes new PhD students Cecilia, Mei, and Siqi.
The lab is also pleased to host undergraduate students Abby, Anabelle, Omar, Signe, and Enkin for the 2024-2025 academic year!
Join the lab
We currently have positions available for graduate students and/or post-doctoral fellows. Click the link above for more information!
Find out more about us by looking us up on the NeuroTree