Laboratory of Cellular and Molecular Neuroscience
The Bowie Lab uses a combination of techniques to study ionotropic glutamate receptors (iGluRs), GABA-A receptors and more recently, Na+ channels. All ion-channel families are widespread in the vertebrate brain and fulfill many important roles in healthy individuals as well as being implicated in disease states associated with postnatal development (e.g. Autism, Schizophrenia), cerebral insult (e.g. Stroke, Epilepsy) and aging disorders (e.g. Alzheimer's disease, Parkinsonism). We are looking at iGluRs, GABA-A receptors and Na+ channels at two inter-related levels. In molecular terms, we are examining the events that occur when each ion-channel family is activated with the aim of developing novel therapeutic compounds. At the cellular level, we are studying the role that iGluRs, GABA-A receptors and Na+ channels fulfill in shaping the behaviour of neuronal circuits and how these processes may be corrected in disease states.
More About Us...
December 2015 - Congratulations to Patricia for the acceptance of her paper in the Journal of Physiology!
December 2015 - Bowie Lab members visit the NIH in Bethesda, Maryland for a symposium in honour of Dr. Mark L. Mayer. Follow this link to watch the talks.
November 2015 - Congratulations to Dr. Michael Accardi for a successful PhD Thesis Defense!
November 2015 - Welcome to Dr. Rafael Koerich Varaschin who recently joined our lab as a post-doctoral fellow.