Laboratory of Cellular and Molecular Neuroscience

Research Interests

The Bowie Lab uses a combination of techniques to study ionotropic glutamate receptors (iGluRs), GABA-A receptors and more recently, Na+ channels. All ion-channel families are widespread in the vertebrate brain and fulfill many important roles in healthy individuals as well as being implicated in disease states associated with postnatal development (e.g. Autism, Schizophrenia), cerebral insult (e.g. Stroke, Epilepsy) and aging disorders (e.g. Alzheimer's disease, Parkinsonism). We are looking at iGluRs, GABA-A receptors and Na+ channels at two inter-related levels. In molecular terms, we are examining the events that occur when each ion-channel family is activated with the aim of developing novel therapeutic compounds. At the cellular level, we are studying the role that iGluRs, GABA-A receptors and Na+ channels fulfill in shaping the behaviour of neuronal circuits and how these processes may be corrected in disease states.

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Lab news

June 2018 - Welcome to our new summer students, Alek Ebbeling and Tian Xie, who will be working on the functional and structural properties of ionotropic glutamate receptors. See their photos and biographies here.

June 2018 - Dr. Bowie recently hosted Drs. David Wyllie and Siddarthan Chandran from the University of Edinburgh who visited McGill as part of an ongoing discussion to build stronger inter-institutional ties. As part of their 3-day visit, Drs. Wyllie and Chandran made a tour of the McGill campus with a mandatory stop at the statue of McGill's founder and fellow Scot, James McGill. (see photos)

May - June 2018 - Having completed their research project at the National Institutes of Physiological Sciences in Okazaki, Japan, Dr. Bowie, Edward and Adamo made the long trip back to Montreal. Before departing, Dr. Bowie visited the husband and wife research team of Drs. Masaki Fukata and Yuko Fukata and their graduate student, Yuri Miyazaki. (see photo)

Join the lab

We currently have positions available for graduate students and/or post-doctoral fellows. Click the link above for more information!

Find out more about us by looking us up on the NeuroTree