Laboratory of Cellular and Molecular Neuroscience
The Bowie Lab uses a combination of techniques to study ionotropic glutamate receptors (iGluRs), GABA-A receptors and more recently, Na+ channels. All ion-channel families are widespread in the vertebrate brain and fulfill many important roles in healthy individuals as well as being implicated in disease states associated with postnatal development (e.g. Autism, Schizophrenia), cerebral insult (e.g. Stroke, Epilepsy) and aging disorders (e.g. Alzheimer's disease, Parkinsonism). We are looking at iGluRs, GABA-A receptors and Na+ channels at two inter-related levels. In molecular terms, we are examining the events that occur when each ion-channel family is activated with the aim of developing novel therapeutic compounds. At the cellular level, we are studying the role that iGluRs, GABA-A receptors and Na+ channels fulfill in shaping the behaviour of neuronal circuits and how these processes may be corrected in disease states.
More About Us...
June 2017 - Check out this interview of Loïs Miraucourt with Charles Tisseyre, talking about night vision!
June 2017 - Dr. Bowie, Erik and Ryan attended the Gordon Research Conference on "Inhibition in the CNS" that was held in the picturesque French Swiss town of Les Diablerets. They took time out from the conference to visit an ice field, Glacier 3000 (see video: http://www.glacier3000.ch/en), located high up on the Swiss Alps.
June 2017 - Dr. Bowie was recently invited to speak at the School of Life Sciences at the University of Sussex, UK where he met with Drs. Ruth Murrell-Lagnado and Andy Penn. He then attended the "Ion-Channel Modulation" Symposium at St. Claire's College, University of Cambridge where he chaired a speaker's session.
June 2017 - Dr. Bowie recently presented the lab's new findings on the neurodevelopment disorder, Fragile X syndrome, at the recent annual meeting of the Canadian Association for Neuroscience that was held in Montreal. See photo.