Laboratory of Cellular and Molecular Neuroscience
The Bowie Lab uses a combination of techniques to study ionotropic glutamate receptors (iGluRs), GABA-A receptors and more recently, Na+ channels. All ion-channel families are widespread in the vertebrate brain and fulfill many important roles in healthy individuals as well as being implicated in disease states associated with postnatal development (e.g. Autism, Schizophrenia), cerebral insult (e.g. Stroke, Epilepsy) and aging disorders (e.g. Alzheimer's disease, Parkinsonism). We are looking at iGluRs, GABA-A receptors and Na+ channels at two inter-related levels. In molecular terms, we are examining the events that occur when each ion-channel family is activated with the aim of developing novel therapeutic compounds. At the cellular level, we are studying the role that iGluRs, GABA-A receptors and Na+ channels fulfill in shaping the behaviour of neuronal circuits and how these processes may be corrected in disease states.
More About Us...
November 2015 - Congratulations to Dr. Michael Accardi for a successful PhD Thesis Defense!
November 2015 - Welcome to Dr. Rafael Koerich Varaschin who recently joined our lab as a post-doctoral fellow.
October 2015 - The Biophysical Society of Canada publishes a newsletter in both the fall and spring of each calendar year. Click here to see the Fall 2015 Newsletter.
October 2015 - Welcome to Mariana Zaichuk from the lab of Dr. Jean-Marc Fritschy at the University of Zurich who recently joined our lab for a 3-month sabbatical stay.
October 2015 - Congrats to Erik Larson who won the prize for the best IPN (junior) graduate student at the 2015 Pharmacology Research Day!