Laboratory of Cellular and Molecular Neuroscience
The Bowie Lab uses a combination of techniques to study ionotropic glutamate receptors (iGluRs), GABA-A receptors and more recently, Na+ channels. All ion-channel families are widespread in the vertebrate brain and fulfill many important roles in healthy individuals as well as being implicated in disease states associated with postnatal development (e.g. Autism, Schizophrenia), cerebral insult (e.g. Stroke, Epilepsy) and aging disorders (e.g. Alzheimer's disease, Parkinsonism). We are looking at iGluRs, GABA-A receptors and Na+ channels at two inter-related levels. In molecular terms, we are examining the events that occur when each ion-channel family is activated with the aim of developing novel therapeutic compounds. At the cellular level, we are studying the role that iGluRs, GABA-A receptors and Na+ channels fulfill in shaping the behaviour of neuronal circuits and how these processes may be corrected in disease states.
More About Us...
May 2021 - Welcome to Dr. Federico Miguez-Cabello, our newest post-doctoral fellow from Spain! Read his bio here.
April 2021 - Congrats to our post-doc, Arjun, who was awarded the Best Trainee Presentation at the Pre-INSAR Blitz TACC (Transforming Autism Care Consortium) Research Forum. Arjun presented his ongoing work on hyperexcitability in Fragile-X Syndrome. Bravo!
March 2021 - Congrats to the Meyerson Lab at Cornell University, as well as Amanda and Patricia from our lab, for their recent paper in eLife that highlights structural and functional aspects of heteromeric GluK2/K5 receptors, the most abundant kainate receptor in the mammalian brain.
Congrats to Dr. Bowie for becoming a recipient of an Ignite Grant that will develop intellectual property associated with AMPA-type ionotropic glutamate receptors. The Ignite Grants are part of the Neuro Commercialization Grant program that aims to accelerate the maturation and commercialization of neuroscience-related technology derived from research conducted at McGill. The objective of the Ignite Grant is to support small-scale validation/proof-of-principle efforts in the development of a neuroscience-related technology.
February 2021 - The lab said goodbye to Ryan with a celebratory take-out lunch. He was also gifted with a caricature done by our very talented post-doc, Arjun. Best of luck at UCSF Dr. Alexander, we will miss you! (See pics here).