Laboratory of Cellular and Molecular Neuroscience

Research Interests

The Bowie Lab uses a combination of techniques to study ionotropic glutamate receptors (iGluRs), GABA-A receptors and more recently, Na+ channels. All ion-channel families are widespread in the vertebrate brain and fulfill many important roles in healthy individuals as well as being implicated in disease states associated with postnatal development (e.g. Autism, Schizophrenia), cerebral insult (e.g. Stroke, Epilepsy) and aging disorders (e.g. Alzheimer's disease, Parkinsonism). We are looking at iGluRs, GABA-A receptors and Na+ channels at two inter-related levels. In molecular terms, we are examining the events that occur when each ion-channel family is activated with the aim of developing novel therapeutic compounds. At the cellular level, we are studying the role that iGluRs, GABA-A receptors and Na+ channels fulfill in shaping the behaviour of neuronal circuits and how these processes may be corrected in disease states.

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Lab news

October 2021 - The long awaited review article, "Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels" was published in Pharmacological Reviews this month. The review features advances in the GluR field over the past decade, with contributions from Dr. Bowie and the lab. Read the full article here.

The Molecular Neuroscience Group (MNG) seminar series has resumed! The Bowie lab hosted the first meeting with presentations from Amanda and Arjun. See the list of upcoming host labs here.

The lab grows again as we welcome Pharmacology undergrad student, Razmig Aredjian.

We are pleased to announce that former undergraduate student, Megan, is now working as a Research Assistant on Fragile X related projects.

Dr. Bowie co-chaired a virtual conference with Dr. David Wyllie on Ionotropic Glutamate Receptors: Structure, Function and Dysfunction that was hosted by the Physiological Society. See the program here.

September 2021 - The lab welcomes a new PhD student, Nils Koch, who will be co-supervised by Dr. Bowie and Dr. Khadra (Dept. Physiology). Welcome Nils!

Join the lab

We currently have positions available for graduate students and/or post-doctoral fellows. Click the link above for more information!

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