Laboratory of Cellular and Molecular Neuroscience

Research Interests

The Bowie Lab uses a combination of techniques to study ionotropic glutamate receptors (iGluRs), GABA-A receptors and more recently, Na+ channels. All ion-channel families are widespread in the vertebrate brain and fulfill many important roles in healthy individuals as well as being implicated in disease states associated with postnatal development (e.g. Autism, Schizophrenia), cerebral insult (e.g. Stroke, Epilepsy) and aging disorders (e.g. Alzheimer's disease, Parkinsonism). We are looking at iGluRs, GABA-A receptors and Na+ channels at two inter-related levels. In molecular terms, we are examining the events that occur when each ion-channel family is activated with the aim of developing novel therapeutic compounds. At the cellular level, we are studying the role that iGluRs, GABA-A receptors and Na+ channels fulfill in shaping the behaviour of neuronal circuits and how these processes may be corrected in disease states.

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Lab news

June 2017 - Dr. Bowie recently presented the lab's new findings on the neurodevelopment disorder, Fragile X syndrome, at the recent annual meeting of the Canadian Association for Neuroscience that was held in Montreal. See photo.

May 2017 - Bowie lab members are involved in the organizing of the "Beautiful Minds" Pint of Science 2017 event, which will take place on May 15-17th, 2017 in Montreal. See poster!

April 2017 - Dr. Bowie recently visited Northwestern University in downtown Chicago where he caught up with some old friends and colleagues from the neuroscience community. See photo.

Join the lab

We currently have positions available for graduate students and/or post-doctoral fellows. Click the link above for more information!

Find out more about us by looking us up on the NeuroTree