Laboratory of Cellular and Molecular Neuroscience
The Bowie Lab uses a combination of techniques to study ionotropic glutamate receptors (iGluRs), GABA-A receptors and more recently, Na+ channels. All ion-channel families are widespread in the vertebrate brain and fulfill many important roles in healthy individuals as well as being implicated in disease states associated with postnatal development (e.g. Autism, Schizophrenia), cerebral insult (e.g. Stroke, Epilepsy) and aging disorders (e.g. Alzheimer's disease, Parkinsonism). We are looking at iGluRs, GABA-A receptors and Na+ channels at two inter-related levels. In molecular terms, we are examining the events that occur when each ion-channel family is activated with the aim of developing novel therapeutic compounds. At the cellular level, we are studying the role that iGluRs, GABA-A receptors and Na+ channels fulfill in shaping the behaviour of neuronal circuits and how these processes may be corrected in disease states.
More About Us...
April 2016 - Brent and Mark's most recent paper (see Publications) has been recommended as being of special significance by the F1000 Faculty!
March 2016 - Welcome to Jihane Nouny from Université de Lille, who is visiting the lab during the next 6 months.
March 2016 - Congratulations to Ryan for obtaining the NSERC Doctoral Award!
March 2016 - Contratulations to Kaitlin and Marika, who obtained a summer studentship and trainee award from GEPROM!