Laboratory of Cellular and Molecular Neuroscience
The Bowie Lab uses a combination of techniques to study ionotropic glutamate receptors (iGluRs), GABA-A receptors and more recently, Na+ channels. All ion-channel families are widespread in the vertebrate brain and fulfill many important roles in healthy individuals as well as being implicated in disease states associated with postnatal development (e.g. Autism, Schizophrenia), cerebral insult (e.g. Stroke, Epilepsy) and aging disorders (e.g. Alzheimer's disease, Parkinsonism). We are looking at iGluRs, GABA-A receptors and Na+ channels at two inter-related levels. In molecular terms, we are examining the events that occur when each ion-channel family is activated with the aim of developing novel therapeutic compounds. At the cellular level, we are studying the role that iGluRs, GABA-A receptors and Na+ channels fulfill in shaping the behaviour of neuronal circuits and how these processes may be corrected in disease states.
More About Us...
December 2017 - Patricia and Hugo publish an article in the Journal of General Physiology. Congratulations!
November 2017 - Dr. Bowie visits Washington DC to attend the Society for Neurosciences meeting and serve on the International Brain Research Organization (IBRO) committee. (see photos)
October 2017 - Dr. Takushi Shimomura from Japan's National Institutes of Physiological Sciences joins the lab for a short sabbatical stay. (see photo)