Dr. Hugo McGuire

Post-Doctoral Fellow

Dr. Hugo McGuire obtained his BSc degree from the Physics department of the Université Laval (Quebec) in 2007. He then specialized in biophysics during his graduate studies at Université de Montréal under the supervision of Dr. Rikard Blunck. Hugo developed an expertise at the border between applied physics, molecular biology and informatics. He generally focused on single-molecule fluorescence imaging and the combination of this technique to voltage-clamp electrophysiology in order to study ion channel molecular mechanisms. He also developed informatics tools for biophysical analysis, notably a program for automating single fluorescent subunit counting data (McGuire et al., 2012, JBC). Hugo joined Dr. Derek Bowie's laboratory as a postdoctoral fellow in December 2014, where he focuses on the development of biophysics tools using nanofabrication techniques.

Fellowships and Awards

2015-2017	NSERC postdoctoral fellowship
2014-2015	Postdoctoral fellowship from the Chemical Biology program of McGill University
2012-2013	Scholarship for end of Ph.D. studies (U. de Montréal)
2009-2012	FRQNT Doctoral research scholarship
2009	GEPROM Doctoral training scholarship (declined: cumulation prohibited)
2008	Award of excellence for the best poster presentation at the XXIII GEPROM annual Symposium
2008-2009	FRQNT Masters research scholarship
2008	GEPROM Masters training scholarship (declined: cumulation prohibited)
2007-2008	Award of Excellence from the Physics department of the Université de Montréal
2004	Undergraduate Admission Scholarship from Université Laval

Publications

Aurousseau MRP, McGuire H, Blunck R, Bowie D. (2014). Fluorescent Subunit Counting Of Membrane‐Bound Proteins in Mammalian Cells. Neuromethods. Book chapter. In Press.

Faure, E, Starek, G, McGuire, H, Bernèche, S and Blunck, R (2012) A Limited 4 Å Radial Displacement of the S4-S5 Linker Is Sufficient for Internal Gate Closing in Kv Channels. J Biol Chem. 287: 40091-40098.

McGuire, H, Aurousseau, MRP, Bowie, D, Blunck, R. (2012) Automating Single Subunit Counting of Membrane Proteins in Mammalian Cells. J Biol Chem. 287: 35912-35921.

Groulx, N, McGuire, H (co-premier auteur), Laprade, R, Schwartz, JL, & Blunck, R. (2011) Single molecule fluorescence study of the Bacillus thuringiensis toxin Cry1Aa reveals tetramerization. J Biol Chem. 286:42274-42282.

McGuire, H, Blunck, R. (2009) Single-channel fluorescence spectroscopy to study conformational changes of ion channels. Médecine/Sciences (Paris). 25(11) :951-954.

Blunck, R, McGuire, H, Hyde, HC, & Bezanilla, F. (2008) Fluorescence detection of the movement of single KcsA subunits reveals cooperativity. Proc. Natl. Acad. Sci. U. S. A 105:20263-20268.