Dr. David MacLean
post-doctoral fellow
David MacLean obtained his Bachelor's of Science from the University of Toronto in 2005, specializing in Neuroscience. He first came to the glutamate receptor field while working in Prof. David Hampson's lab on metabotropic glutamate receptors. An honours thesis on recombinant AMPA receptors in Prof. John F. MacDonald's lab later shifted his interests towards ionotropic glutamate receptors, which led him to join the lab in September 2005. He is currently investigating the role of anions and cations in the gating and desensitization behavior of kainate receptors as well as the determinants of agonist efficacy at both AMPA and KA receptors.
Awards and Scholarships:
2010 |
Standard Life Dissertation Fellowship ($5000, one time fellowship) |
2008 |
Invited and attended the FENS Synapse Summer School, Bordeaux, France |
2007 |
Banting & Best CIHR Doctoral Fellowship GEPROM bourse de prestige (declined) |
2006 |
Best Research Proposal, 6th Annual McGill Biomedical Conference McGill Faculty of Medicine Internal Studentship Award (declined) CIHR Masters Student Scholarship |
2005 |
McGill University Recruitment Excellence Fellowship Dean's Honor List, University of Toronto |
2004 |
Dean's Honor List, University of Toronto Life Science Summer Studentship, Pharmacology, University of Toronto |
2003 |
Dean's Honor List, University of Toronto St. Michael’s In-course Scholarship |
2002 |
Dean's Honor List, University of Toronto Induction of Golden Key International Honor Society, U. Toronto |
Publications:
Maclean,D.M., and Bowie,D. (2011). TARP regulation of AMPA receptor antagonism:a problem of interpretation. J. Physiol.
The 2 Glutamate-Like Receptor Undergoes Similar Conformational Changes as Other Ionotropic Glutamate Receptors. MacLean, D.M. (2009) J. Neurosci. (29): 6767-6768. Journal Club.
Wong, A.Y.C., MacLean, D.M., Bowie, D. (2007) Na+/Cl- Dipole Couples Agonist Binding To Kainate Receptor Activation. J Neurosci. 27(25): 6800-6809.
Kuang, D., Chang, B., MacLean, D., Wang, M., Hampson, D. (2006) Ancestral reconstruction of the ligand binding pocket of Family C G-protein coupled receptors. PNAS 103:14050-14055.
Hampson, D., Kuang, D., Yao, Y., Wang, M., MacLean, D., Chang, B. (2006). Ancestral reconstruction of the ligand binding pocket of Family C G-protein coupled receptors. Soc. Neurosci. Abstrs.,