Lysosomal Studies

Musunuru K., Morales C.R., Rader D.J. et al. (2010) From DNA sequence variant to lipoprotein phenotype at a novel cholesterol and myocardial infarction locus. Nature 466: 714-721

Zeng J., Morales C.R. 2009 The inactivation of the sortilin gene leads to a partial disruption of prosaposin trafficking to the lysosomes. Exp. Cell Res. 315: 3112-312

Yuan L., Morales C.R. 2009 A stretch of 17 Amino Acids in the Prosaposin C-Terminus is Critical for its Binding to Sortilin and Targeting to Lysosomes. J. Histochem. Cytochem. 58:287-300, 2010

Canuel M., Bhattacharyya N., Balbis A., Morales C.R. 2009 Sortilin and prosaposin localize to detergent-resistant membrane microdomains. Exp. Cell Res. 315: 240-247

Canuel M., Korkidakis A., Konnyu K., Morales C.R. 2008 Sortilin mediates the lysosomal targeting of cathepsins D and H. Biochem. Biophys. Res. Comm. 373: 292-297

Canuel M., Lefrancois S., Zeng J., Morales C.R. 2008 AP-1 and retromer play opposite roles in the trafficking of sortilin between the TGN and lysosomes. Biochem. Biophys. Res. Comm. 366: 724-730

Seyrantepe V., Canuel M., Zeng J., Landry L., Feng L., Durand S., Carpentier S., Gravel R.A., Michaud J., Marchesini S., Zwingmann C., Morales C.R., Levade T., Pshezhetsky A.V. 2008 Mice deficient in the Neu4 sialidase exhibit abnormal ganglioside catabolism and lysosomal storage. Hum. Mol. Genet. 17: 1556-1568

Ni X., C.R. Morales 2006 The trafficking of acid sphingomyelinase (ASM) to the lysosomes is mediated by sortilin and the mannose 6-phosphate receptor. Traffic. 7: 859-863

Lefrancois S., Canuel M., Zeng J. Morales C.R. 2005 Inactivation of sortilin (a novel lysosomal sorting receptor) by dominant negative competition and RNA interference. Biol. Proced. Online 7: 17-25

Hassan J.A., J. Zeng, N. Xiaoyan, C.R. Morales 2004 The trafficking of prosaposin (SGP-1) and GM2AP to the lysosomes of TM4 Sertoli cells is mediated by sortilin and monomeric adaptor proteins. Mol. Rep. Dev. 68:476-83

Zeng J., A.J. Hassan, C.R. Morales 2004 Study of the mouse sortilin gene. Effects of its transient silencing by RNA interference in TM4 Sertoli cells. Mol. Rep. Dev. 68: 469-475

Zhou D., C. Cantu III, Y. Sagiv, A.B. Kulkarni, X. Qi, D.J. Mahuran, C.R. Morales, G. Grabowski, K. Benlagha, P. Savage, A. Bendelac, L. Teyton 2004 Editing of CD1d bound-lipid antigens by endosomal lipid transfer proteins. Science 303: 523-527

Lefrancois S., J. Zeng, A. Hassan, C. Canuel, C.R. Morales 2003 The lysosomal trafficking of sphingolipid activator proteins (SAPs) is mediated by sortilin EMBO J. 22: 1-8

Reproductive Studies

Morales C.R., Marat A.L., Ni X., Smith B.T., Argraves W.S. 2008 ATP-Binding Cassette Transporters ABCA1, ABCA7 and ABCG1 in Mouse Spermatozoa. Biochem. Biophys. Res. Comm. 376: 472-477

Argraves S.W., C.R. Morales 2004 Uterine and oviduct expression of the cubilin, megalin, apolipoprotein J and apolipoprotein A-1. Mol. Rep. Dev. 69: 419-427

(Top of Page)