Publications
Brown SE, Fraga MF, Weaver IC, Berdasco M, Szyf M.
Variations in DNA methylation patterns during the cell cycle of HeLa
cells.
Epigenetics. 2007 Jan-Mar;2(1):54-65. Epub 2007 Jan 15.
PMID: 17965591
D'Alessio AC, Weaver IC, Szyf M.
Acetylation-induced transcription is
required for active DNA demethylation in
methylation-silenced genes.
Mol Cell Biol. 2007 Nov;27(21):7462-74. Epub 2007 Aug 20.
PMID: 17709385 [PubMed - in process]
Szyf M.
The dynamic epigenome and its implications in toxicology.
Toxicol Sci. 2007 Nov;100(1):7-23. Epub 2007 Aug 3.
PMID: 17675334
Szyf M, Weaver I, Meaney M.
Maternal care, the epigenome and phenotypic differences in behavior.
Reprod Toxicol. 2007 Jul;24(1):9-19. Epub 2007 May 10. Review.
PMID: 17561370
Brown SE, Szyf M.
Epigenetic programming of the rRNA promoter by MBD3.
Mol Cell Biol. 2007 Jul;27(13):4938-52. Epub 2007 Apr 23.
PMID: 17452452
Nuyt AM, Szyf M.
Developmental programming through epigenetic changes.
Circ Res. 2007 Mar 2;100(4):452-5. No abstract available.
PMID: 17332436
Weaver IC, D'Alessio AC, Brown SE, Hellstrom IC, Dymov S,
Sharma S, Szyf M,
Meaney MJ.
The transcription factor nerve growth factor-inducible protein a mediates
epigenetic programming: altering epigenetic marks by immediate-early genes.
J Neurosci. 2007 Feb 14;27(7):1756-68.
PMID: 17301183
Ou JN, Torrisani J, Unterberger A, Provençal N,
Shikimi K, Karimi M, Ekström
TJ, Szyf M.
Histone deacetylase inhibitor Trichostatin
A induces global and gene-specific DNA
demethylation in human cancer cell lines.
Biochem Pharmacol. 2007 May 1;73(9):1297-307. Epub 2007 Jan 5.
PMID: 17276411
Torrisani J, Unterberger A, Tendulkar SR, Shikimi K, Szyf
M.
AUF1 cell cycle variations define genomic DNA methylation by regulation of
DNMT1
mRNA stability.
Mol Cell Biol. 2007 Jan;27(1):395-410. Epub 2006 Oct 9.
PMID: 17030625
Unterberger A, Andrews SD, Weaver IC, Szyf M.
DNA methyltransferase 1 knockdown activates a replication stress
checkpoint.
Mol Cell Biol. 2006 Oct;26(20):7575-86.
PMID: 17015478
Milutinovic S, D'Alessio AC, Detich N, Szyf M.
Valproate induces widespread epigenetic
reprogramming which involves
demethylation of specific genes.
Carcinogenesis. 2007 Mar;28(3):560-71. Epub 2006 Sep 28.
PMID: 17012225
Szyf M.
Targeting DNA methylation in cancer.
Bull Cancer. 2006 Sep 1;93(9):961-72.
PMID: 16980240
D'Alessio AC, Szyf M.
Epigenetic tête-à-tête: the bilateral relationship between chromatin
modifications and DNA methylation.
Biochem Cell Biol. 2006 Aug;84(4):463-76. Review.
PMID: 16936820
Szyf M.
Therapeutic implications of DNA methylation.
Future Oncol. 2005 Feb;1(1):125-35. Review.
PMID: 16555982
Champagne FA, Weaver IC, Diorio J, Dymov S, Szyf M, Meaney
MJ.
Maternal care associated with methylation of the estrogen receptor-alpha1b
promoter and estrogen receptor-alpha expression in the medial preoptic area
of
female offspring.
Endocrinology. 2006 Jun;147(6):2909-15. Epub 2006 Mar 2.
PMID: 16513834
Zhang TY, Bagot R, Parent C, Nesbitt C, Bredy TW, Caldji
C, Fish E, Anisman
H, Szyf M, Meaney MJ.
Maternal programming of defensive responses through sustained effects on
gene
expression.
Biol Psychol. 2006 Jul;73(1):72-89. Epub 2006 Feb 28. Review.
PMID: 16513241
Weaver IC, Meaney MJ, Szyf M.
Maternal care effects on the hippocampal transcriptome and
anxiety-mediated
behaviors in the offspring that are reversible in adulthood.
Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3480-5. Epub 2006 Feb 16.
PMID: 16484373
Weaver IC, Champagne FA, Brown SE, Dymov S, Sharma S,
Meaney MJ, Szyf M.
Reversal of maternal programming of stress responses in adult offspring
through
methyl supplementation: altering epigenetic marking later in life.
J Neurosci. 2005 Nov 23;25(47):11045-54.
PMID: 16306417
Szyf M, Weaver IC, Champagne FA, Diorio J, Meaney MJ.
Maternal programming of steroid receptor expression and phenotype through
DNA
methylation in the rat.
Front Neuroendocrinol. 2005 Oct-Dec;26(3-4):139-62. Epub 2005 Nov 21.
Review.
PMID: 16303171
Meaney MJ, Szyf M.
Environmental programming of stress responses through DNA methylation:
life at
the interface between a dynamic environment and a fixed genome.
Dialogues Clin Neurosci. 2005;7(2):103-23. Review.
PMID: 16262207
Meaney MJ, Szyf M.
Maternal care as a model for experience-dependent chromatin plasticity?
Trends Neurosci. 2005 Sep;28(9):456-63. Review.
PMID: 16054244
Szyf M.
DNA methylation and demethylation as targets for anticancer therapy.
Biochemistry (Mosc). 2005 May;70(5):533-49. Review.
PMID: 15948707
Fish EW, Shahrokh D, Bagot R, Caldji C, Bredy T, Szyf M,
Meaney MJ.
Epigenetic Programming of Stress Responses through Variations in Maternal
Care.
Ann N Y Acad Sci. 2004 Dec;1036:167-80.
PMID: 15817737
Szyf M, Pakneshan P, Rabbani SA.
DNA methylation and breast cancer.
Biochem Pharmacol. 2004 Sep 15;68(6):1187-97. Review.
PMID: 15313416
Weaver IC, Diorio J, Seckl JR, Szyf M, Meaney MJ.
Early environmental regulation of hippocampal glucocorticoid receptor gene
expression: characterization of intracellular mediators and potential
genomic
target sites.
Ann N Y Acad Sci. 2004 Jun;1024:182-212. Review.
PMID: 15265782
Weaver IC, Cervoni N, Champagne FA, D'Alessio AC, Sharma
S, Seckl JR, Dymov
S, Szyf M, Meaney MJ.
Epigenetic programming by maternal behavior.
Nat Neurosci. 2004 Aug;7(8):847-54. Epub 2004 Jun 27.
PMID: 15220929
Szyf M, Pakneshan P, Rabbani SA.
DNA demethylation and cancer: therapeutic implications.
Cancer Lett. 2004 Aug 10;211(2):133-43. Review.
PMID: 15219937
Milutinovic S, Brown SE, Zhuang Q, Szyf M.
DNA methyltransferase 1 knock down induces gene expression by a mechanism
independent of DNA methylation and histone deacetylation.
J Biol Chem. 2004 Jul 2;279(27):27915-27. Epub 2004 Apr 15.
PMID: 15087453
DNA methylation and cancer therapy.
Drug Resist Updat. 2003 Dec;6(6):341-53.
PMID: 14744498
Szyf
M
(PDF)
Methylated DNA binding protein 2 antisense inhibitors suppress tumorigenesis
of human cancer lines in vitro and in vivo.
Carcinogenesis. 2003 Dec 19 [Epub ahead of print]
PMID: 14688029 [PubMed - as supplied by publisher]
Campbell
PM, Bovenzi V, Szyf M.
(PDF)
Enhanced antitumor activity of a combination of MBD2-antisense
electrotransfer gene therapy and bleomycin electrochemotherapy.
J Gene Med. 2003 Oct;5(10):893-9.
PMID: 14533198
Ivanov MA, Lamrihi B, Szyf M, Scherman D, Bigey P. (PDF)
Valproate induces replication-independent active DNA demethylation.
J Biol Chem. 2003 Jul 25;278(30):27586-92. Epub 2003 May 14.
PMID: 12748177 [PubMed - indexed for MEDLINE]
Detich
N, Bovenzi V, Szyf M (PDF)
Targeting DNA methylation in cancer.
Ageing Res Rev. 2003 Jul;2(3):299-328.
PMID: 12726777 [PubMed - in process] Szyf
M (PDF)
The methyl donor S-Adenosylmethionine inhibits active demethylation
of DNA: a candidate novel mechanism for the pharmacological effects of S-Adenosylmethionine.
J Biol Chem. 2003 Jun 6;278(23):20812-20. Epub 2003 Apr 03.
PMID: 12676953 [PubMed - indexed for MEDLINE] Detich
N, Hamm S, Just K, Knox JD, Szyf M
(PDF)
Epigenomic stress response: Knock-down of DNA methyltransferase
1 triggers an intra S-phase arrest of DNA replication and induction of stress
response genes.
J Biol Chem. 2003 Feb 7 {Milutinovic
S, Zhuang Q, Niveleau A, Szyf M.} {PDF}
Human DNA methyltransferase gene DNMT1 is regulated by the
APC pathway.
Carcinogenesis. 2003 Jan;24(1):17-24. {Campbell
PM, Szyf M.} {PDF}
Antisense knock down of MBD2/demethylase inhibits tumorigenesis {Slack A et al., 2002, J Gene Med, 4(4), 381-9} {PDF}
MBD2 demethylase activates and demethylates in a promoter
specific manner {Detich
N et al., 2002, J Biol Chem, 277(39), 35791-4}
{PDF}
Demethylase activity is directed by chromatin structure {Cervoni
N. and Szyf M., 2001, J Biol Chem, 276(44), 40778-87.} {Cervoni N et al.,
2002, J Biol Chem, 277(28), 25026-31}
DNA methylation is a reversible biological signal; discovery of DNA demethylase. {Bhattacharya S. K. et al., 1999, Nature, 397(6720), 579-83, Cervoni N. et al., 1999, J Biol Chem, 274(13), 8363-6, Ramchandani S. et al., 1999, Proc Natl Acad Sci U S A, 96(11), 6107-12} {PDF}
A conserved 3'-untranslated element mediates growth regulation of dna methyltransferase 1 and inhibits its transforming activity {Detich N. et al., 2001, J Biol Chem, 276(27), 24881-24890.} {PDF}
DNMT1 is required for initiation of DNA replication
{Knox
J. D. et al., 2000, J Biol Chem, 275(24), 17986-17990} {PDF}
Inhibition of DNMT1 inhibits cancer by a DNA methylation independent
mechanism
{Milutinovic
S. et al., 2000, J Biol Chem, 275(9), 6353-9} {PDF}
Inhibition of DNMT1 inhibits cancer growth, antisense inhibitors of DNMT1
candidate anticancer therapeutics. {MacLeod A. R. and Szyf M., 1995, J Biol
Chem, 270(14), 8037-43} {Ramchandani S. et al., 1997, Proc Natl Acad Sci U
S A, 94(2), 684-9}
Ras and T antigen oncogenic pathways induce DNMT1 expression
{MacLeod A. R. et al., 1995, J Biol Chem, 270(19), 11327-37, Rouleau J. et
al., 1995, J Biol Chem, 270(4), 1595-1601} {Slack A. et al., 1999, J Biol
Chem, 274(15), 10105-12}
Antisense knockdown of DNMT1 induced cellular differentiation {Szyf M. et al., 1992, J Biol Chem, 267(18), 12831-6}
Specific cis acting DNA signals determine DNA methylation patterns {Szyf M. et al., 1990, Mol Cell Biol, 10(8), 4396-400}
