Sample of Issued Patents derived from laboratory research:
1. U.S. patent,5,578,716 DNA methyltransferase antisense oligonucleotides 2. U. S. patent 5,5919,772 Antisense oligonucleotides having tumoreginicity inhibiting activity. 3. U. S. patent 6,054,439 antisense oligonucleotides having tumoreginicity inhibiting activity. 4. U. S. patent 6,184,211 Inhibition of DNA methyltransferase 5. 5. U. S. patent 6,066,625 Optimized antisense oligonucleotides complementary to DNA methyltransferase sequences. 6. Published PCT application: DNA demethylase therapeutic and diagnostic uses thereof PCT 1770-183. |
Current projects in the laboratory;
Delineating the mechanisms responsible for cell cycle
regulation of DNMT1 Deciphering mechanisms of active demethylation Analyzing the role of demethylase, MBD2 and global demethylation
in tumorigenesis and behavioral imprinting |