G protein-coupled signal transduction systems

Hébert Lab, Department of Pharmacology and Therapeutics, McGill University


PEOPLE

Phan Trieu
Research Assistant


Education:

B.Sc. Biochemistry, Université de Montréal, Montréal.

Research:

I have had the opportunity to be associated with many different projects involving studies of the trafficking and signalling of G protein-coupled receptors (GPCRs), G proteins and their effectors, using a variety of techniques such as BRET, RT-PCR, patch clamp among numerous others. I also participate in the maintenance of the laboratory.

Selected Publications:

Wang L, Dennis AT, Trieu P, Charron F, Ethier N, Hebert TE, Wan X, Ficker E. (2009) Intracellular potassium stabilizes human ether-à-go-go-related gene channels for export from endoplasmic reticulum. Mol Pharmacol. 75(4):927-37.

Richer M, David M, Villeneuve LR, Trieu P, Ethier N, Pétrin D, Mamarbachi AM, Hébert TE. (2008) GABA-B(1) Receptors are Coupled to the ERK1/2 MAP Kinase Pathway in the Absence of GABA-B(2) Subunits. J Mol Neurosci. 38(1):67-79

Rebois RV, Robitaille M, Pétrin D, Zylbergold P, Trieu P, Hébert TE. (2008) Combining protein complementation assays with resonance energy transfer to detect multipartner protein complexes in living cells. Methods. 45(3):214-8.

Baragli A, Grieco ML, Trieu P, Villeneuve LR, Hébert TE. (2007) Heterodimers of adenylyl cyclases 2 and 5 show enhanced functional responses in the presence of Galphas. Cell Signal. 20(3):480-92

Rebois RV, Robitaille M, Galés C, Dupré DJ, Baragli A, Trieu P, Ethier N, Bouvier M, Hébert TE. (2006) Heterotrimeric G proteins form stable complexes with adenylyl cyclase and Kir3.1 channels in living cells. J Cell Sci. 119(Pt 13):2807-18.