A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Dr. NaguibMechawar, PhD
Adult brain neurogenesis
Douglas Mental Health University Institute
6875 LaSalle Blvd
514-761-6131 ext. 3365
Dr. Mechawar joined the Douglas Institute and the McGill Group for Suicide Studies as an independent investigator in 2007 and is currently an Assistant Professor in the Department of Psychiatry at McGill University. He is also the Director of the Sam Lal Douglas Institute Brain Bank, the oldest and most important brain bank in Canada. Dr. Mechawar is mainly interested in the cellular neuroanatomy of major depression and suicide. Different projects are currently underway in his laboratory to investigate the fine neuroanatomical manifestations of altered plasticity in postmortem brains from individuals having suffered from mood disorders. These studies are focused on limbic brain regions, namely, the hippocampus, amygdala, and anterior cingulate cortex, which are well-known for their implication in emotional processing. A related focus of Dr. Mechawar’s research is to investigate how adult neurogenesis in the limbic brain is affected in mood disorders and by drug exposure (antidepressants, nicotine, growth factors). These projects are funded by CIHR, CFI, NSERC, FRSQ, AFSP, and the FFCR.
Graduate: PhD, Université de Montréal
Hercher C, Canetti L, Turecki G, Mechawar N. Anterior cingulate pyramidal neurons display altered dendritic branching in depressed suicides. J Psychiatr Res. 2009. In press.
Hercher C, Parent M, Canetti L, Flores C, Turecki G, Mechawar N. Alcohol dependence-related increase of glial cell density in the anterior cingulate cortex of suicides. J Psychiatry Neurosci. 2009;34:281-288.
Hercher C, Turecki G, Mechawar N. Through the looking glass: examining neuroanatomical evidence for cellular alterations in major depression. J Psychiatr Res. 2009;43:947-961.
Ernst C, Mechawar N, Turecki G. Suicide neurobiology. Prog Neurobiol. 2009;89:315-333.
Sequeira A, Mamdani F, Ernst C, Vawter M, Bunney WE, Klempan T, Gratton A, Benkelfat C, Rouleau GA, Mechawar N, Turecki G. Global brain gene expression analysis links glutamatergic and GABAergic alterations to suicide and major depression. PLoS ONE. 2009;4(8):e6585.
Fiori LM, Mechawar N, Turecki G. Identification and characterization of SAT1 promoter variants and methylation status in suicide completers. Biol Psychiatry. 2009;66:460-467.
Moyse E, Segura S, Liard O, Mahaut S, Mechawar N. Microenvironmental determinants of adult neural stem cell proliferation and lineage commitment in the healthy and injured central nervous system. Curr Stem Cell Res Ther. 2008;3:163-184.
Krantic S, Mechawar N, Reix S, Quirion R. Molecular basis of programmed cell death involved in neurodegeneration. Trends Neurosci. 2005;28:670-676.
Mechawar N, Saghatelyan A, Grailhe R, Scoriels L, Gheusi G, Gabellec MM, Lledo PM, Changeux JP. Nicotinic receptors regulate the survival of newborn neurons in the adult olfactory bulb. Proc Natl Acad Sci USA. 2004;101:9822-9826.
Mechawar N, Watkins KC, Descarries L. Ultrastructural features of the acetylcholine innervation in the developing parietal cortex of rat. J Comp Neurol. 2002;443:250-258.