A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Dr. GiamalN.Luheshi, PhD
Douglas Mental Health University Institute
6875 LaSalle Blvd
Dr. Luheshi is an Associate Professor in the Department of Psychiatry at the Douglas Mental Health University Institute. His research work is centred on understanding the interactions between the peripheral immune system and the brain in inflammation. In particular, his work is focused on the role the immune mediators cytokines, such as interlukin-1, and adipokines like leptin and their involvement in the hostsís response to pathogens. In recent years Dr Luheshi has applied his expertise in this area to study the link between inflammatory events during pregnancy and the effects this could have on the developing fetus. This research is based on epidemiological data associating maternal infection during pregnancy with increased incidence of a number of neurodevelopmental disorders such as schizophrenia in the adult offspring. Another area of interest is the investigation of the mechanisms underlying the altered immunity that is common in obese individuals. Recent research has demonstrated that responses to exogenous pathogenic stimuli are exaggerated as a function of adiposity, suggesting a change in functional immunity. This could have repercussion for a number of secondary conditions associated with obesity such as cardiovascular, and metabolic diseases and the more recently recognized link with psychiatric disorders such as depression.
Undergraduate: GI Biol, Metropolitan University of Manchester, UK
Society for Neuroscience
Rummel C, Inoue W, Poole S, Luheshi GN. Leptin regulates leukocyte recruitment into the brain following systemic LPS-induced inflammation. Molec. Psychiatry. EPub. 2010. In print.
Lafrance V, Inoue W, Kan B, Luheshi GN. Leptin modulates cell morphology and cytokine release from microglia. Brain Behav. Immune. 2010;24(3):358-365.
Pohl J, Woodside B, Luheshi GN. Changes in hypothalamically mediated acute phase inflammatory responses to lipopolysaccharide in diet-induced obese rats. Endocrinology. 2009;150(11):4901-10.
Rummel S, Inoue W, Sachot S, Poole S, Hubscle T, Luheshi GN. Selective contribution of IL-6 and leptin to brain inflammatory signals induced by systemic LPS injection in mice. J. Comparative Neurology. 2008;511(3):373-95.
Aguilar-Valles A, Poole S, Mistry Y, Williams S, Luheshi G.N. Attenuated fever in rats during late pregnancy is linked to suppressed IL-6 production after localised inflammation with turpentine. J.Physiol. (Lond.). 2007;583(1):391-403.
Pinteaux E, Inoue W, Schmidt L, Molina-Holgado F, Rothwell NJ, Luheshi GN. Leptin induces interleukin-1beta release from rat microglial cells through a caspase-1 independent mechanism. J. Neurochem. 2007;102(3):826-33.
Ashdown H, Dumont Y, Poole S, Boksa P, Luheshi GN. The role of cytokines in mediating effects of prenatal infection on the fetus: Implications for schizophrenia. Molecular Psychiatry. 2006;11(1):47-55.
Sachot C, Poole S, Luheshi GN. Circulating leptin mediates LPS-induced anorexia and fever in rats. J.Physiol. (Lond.). 2004;15;561(Pt 1):263-72.
Luheshi GN, Gardner JD, Rushforth DA, Loudon AS, Rothwell NJ. Leptin actions on food intake and body temperature are mediated by interleukin-1. Proc.Natl.Acad.Sci. USA. 1999;96:7047-7052.
Gardner JD, Rothwell NJ, Luheshi GN. Leptin affects food intake via CRF receptor mediated pathways. Nature Neuroscience. 1998;1(2):103.