A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
 


Dr. JohnC.S.Breitner, M.D.,M.P.H.
Pfizer Professor and Chair


Geriatric Psychiatry, Preventive Medicine



Douglas Mental Health Research Institute
6875 LaSalle Blvd, Pavillon Perry (E-2211)
Montreal
Quebec
H4H 1R3
514-761-6131 ext. 3940
514-221-4700

john.breitner@mcgill.ca



Dr. Breitner has devoted his career to the study of Alzheimer’s disease (AD), its risk factors, and their implications for its prevention. Although an expert clinician, he is better known as a researcher. His early work on familial aggregation in AD evolved to twin studies of heritability and environmental risk factors. He then founded the Cache County Study of Memory in Aging, a longitudinal investigation of genetic and environmental antecedents of AD, which has produced over 100 scientific papers. More recently he was Chair of the randomized placebo-controlled Alzheimer’s Disease Anti-inflammatory Prevention Trial (ADAPT) that evaluated two nonsteroidal anti-inflammatory drugs for primary prevention of AD in healthy elderly. As that trial winds down, he recently joined the McGill faculty to establish the new StoP-AD Centre at the Douglas. This Centre is devoted to identification and quantitation of AD markers in the pre-symptomatic stage of the disease, and to preliminary testing of experimental strategies for that may prevent progression of pre-symptomatic disease to dementia. Dr. Breitner is has mentored more than 15 individuals who have gone on to tenure-track academic positions, nine of these whom have independent NIH funding, 3 are now Chairs and one the Executive Editor of a leading Alzheimer’s disease journal.


Residency: Oregon Health Sciences University (Psychiatry and General Preventive Medicine)
New York Hospital – Cornell Medical Centre (Psychiatry)

Public Health Training: Johns Hopkins Bloomberg School of Public Health (M.P.H.)


Fellow, American Psychopathological Association
Fellow, American College of Neuropsychopharmacology

Lifetime member, Delta Omega Honorary Public Health Society



Breitner JC, Baker LD*, Montine TJ, Meinert CL, Lyketsos CG, Ashe KH, Brandt J, Craft S, Evans DE, Green RC, Ismail MS, Martin BK, Mullan MJ, Sabbagh M, Tariot PN; ADAPT Research Group. Extended results of the Alzheimer’s disease anti-inflammatory prevention trial. Alzheimers Dement 2011;7:402-11.

ADAPT Research Group, Martin BK, Szekely C*, Brandt J, Piantadosi S, Breitner JC, Craft S, Evans D, Green R, Mullan M. Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib. Arch Neurol 2008;65:896-90

ADAPT Research Group, Lyketsos CG, Breitner JC, Green RC, Martin BK, Meinert C, Piantadosi S, Sabbagh M. Naproxen and celecoxib do not prevent AD in early results from a randomized controlled trial. Neurology. 2007;68:1800-8. Epub 2008 May 12.

Khachaturian AS*, Zandi PP*, Lyketsos CG, Hayden KM*, Skoog I, Norton MC*, Tschanz JT*, Mayer LS, Welsh-Bohmer KA, Breitner JC. Antihypertensive medication use and incident Alzheimer disease: the Cache County Study. Arch Neurol. 2006;63:686-692.

Khachaturian AS*, Corcoran C, Mayer LS, Zandi PP*, Breitner JC, Cache County Study Investigators. Apolipoprotein E epsilon4 count affects age at onset of Alzheimer disease, but not lifetime susceptibility: The Cache County Study. Arch Gen Psychiatry 2004;61(5):518-524.

Zandi PP*, Anthony JC, Khachaturian AS*, Stone SV, Gustafson D, Tschanz JT*, Norton MC*, Welsh-Bohmer KA, Breitner JC. Reduced risk of alzheimer disease in users of antioxidant vitamin supplements: The cache county study. Arch Neurol 2004;61:82-88.

Zandi PP*, Carlson MC*, Plassman BL*, WelshBohmer KA, Mayer LS, Steffens DC*, Breitner JCS. Hormone replacement therapy and incidence of alzheimer disease in older women - the cache county study. JAMA Journal of the American Medical Association 2002;288:2123-2129.

Plassman BL*, Havlik RJ, Steffens DC*, Helms MJ, Newman TN, Drosdick D, Phillips C, Gau BA, Welsh-Bohmer KA, Burke JR, Guralnik JM, Breitner JC. Documented head injury in early adulthood and risk of Alzheimer's disease and other dementias. Neurology. 2000;55:1158-1166.

Breitner JCS, Gau BA, Welsh KA, Plassman BL*, McDonald WM*, Helms MJ, et al. Inverse association of anti-inflammatory treatments and Alzheimer's disease: initial results of a co-twin control study. Neurology 1994;44:227-232.

Breitner JCS, Folstein MF. Familial Alzheimer dementia: a prevalent disorder with specific clinical features. Psychological Medicine 1984;14:63-80.