A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Dr. CeciliaFlores, PhD
Douglas Mental Health University Institute
6875 LaSalle Blvd
514-761-6131 ext. 2814
Dr. Flores is an Assistant Professor in the Department of Psychiatry and an associate member of the Department of Neurology and Neurosurgery at McGill University. She studied at the Center for Studies in Behavioral Neurobiology at Concordia University and received her PhD in 2000. She did postdoctoral studies at Harvard Medical School and the Montreal Neurological Institute. Her early research work was concerned with the long-lasting changes in the brain brought about by exposure to stimulant drugs. She focused on changes within the midbrain dopaminergic system, with particular emphasis on the role of the neurotrophic factor, basic fibroblast growth factor (bFGF), in these lasting changes. Her current work concerns the role of the neural guidance molecules, the netrins and their receptors, in brain development and in neuroplasticity in the adult brain brought about by exposure to stimulant drugs. In one ongoing project she has shown that netrin receptors, located on dopaminergic neurons, are intimately involved in the differential development of the dopaminergic input to the striatum and frontal cortex affecting behavioural responses in the adult. Dr. Flores runs an active research laboratory at the Douglas Hospital Research Centre. She holds grants from CIHR, NSERC, and CFI. She is actively involved in teaching and administrative work within her department and the university.
Graduate: PhD, Concordia University
Argento J, Arvanitogiannis A., Flores C. Juvenile Exposure to Methylphenidate Reduces Cocaine Reward and Alters Netrin-1 Receptor Expression in Adulthood. Behavioural Brain Research. (In Press)
Aguilar-Valles A, Jung S, Poole S, Flores, C, Luheshi G. Leptin and interleukin-6 alter the development of mesolimbic dopamine neurons in a model of prenatal inflammation in rat.Psychoneuroendocrinology. (In Press)
Flores C. Role of netrin-1 in the organization of the mesocorticolimbic dopamine system. Journal of Psychiatry and Neuroscience. 36(5): 296-310.
Yetnikoff L, Almey MA, Arvanitogiannis A, Flores C. Abolition of the behavioral phenotype of adult netrin-1 receptor deficient mice by exposure to amphetamine during the juvenile period. Psychopharmacology. 2011;217: 505-514.
Manitt C, Mimee A, Eng C, Pokinko M, Stroh T, Cooper HM, Kolb B, and Flores C. The netrin receptor DCC is required in the pubertal organization of mesocortical dopamine circuitry. Journal of Neuroscience. 2011;31(23): 8381-8394. *see This Week in The Journal section for commentary
Manitt C*, Labelle-Dumais C*, Eng C, Grant A, Mimee A, Stroh T, Flores C. Peri-pubertal emergence of UNC-5 homologue expression by dopamine neurons in rodents. PLoS One. 2010;5(7): e11463 *contributed equally to this work
Aguilar-Valles A, Flores, C, Luheshi G. Prenatal inflammation-induced hypoferremia alters dopamine function in the offspring. PLoS One. 2010;5(6): e10967
Yetnikoff L, Eng C, Benning S, Flores C. Netrin1 receptor in the ventral tegmental area is required for sensitization to amphetamine. European Journal of Neuroscience. 2010;31: 1292-1302
Grant A, Fathalli F., Rouleau G., Joober R., Flores C. Association between schizophrenia and genetic variation in DCC: a case-control study. Schizophrenia Research. (In Press)