A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Dr. J. BrunoDebruille, MD,Psychiatrist,PhD
Schizophrenia, psychosis, delusions
Cognition, semantics, N400 event-related brain potential
Direct functional brain imaging
Douglas Institute Research Centre, F1105, FBC-1
6875 LaSalle Blvd
514-761-6131 ext. 3405
Dr. Debruille is an Associate Professor of clinical psychiatry in the Division of Adult Psychiatry at McGill University. Dr. Debruille conducts research aimed at understanding the neurocognitive mechanisms of psychotic symptoms (and of the effects of antipsychotic medications). He tests whether these mechanisms are part of physiological functionning. For delusions, the neurocognitive mechanisms he found involve the brain processes that generate the so-called N400 potential. Thus, he also conducts research aimed at identifying the nature of the computations performed by these processes. He collaborates with Mathieu Brodeur and Martin Lepage to explore the neurocognitive mechanisms underlying visual illusions. In his clinical practice, he specializes in psychotherapies for these disorders at the 2nd line psychotic disorder program of the Douglas Institute.
La Salpêtrière Hospital, Paris; St Anne Hospital, Paris
Cognitive Neuroscience Society
Society for Psychophysiological Research
Debruille JB. The N400 potential could index a semantic inhibition. Brain Research Reviews. 2007;56(2):472-7.
Debruille JB, Kumar N, Saheb D, Chintoh A, Gharghi D, Lionnet C, King S. Delusions and processing of discrepant information: An event-related brain potential study. Schizophrenia Research. 2007;89(1-3):261-277.
Renoult L, Prévost M, Brodeur MB, Lionnet C, Joober R, Malla A, Debruille JB. P300 asymmetry and positive symptom severity: A study in the early stage of a first episode of psychosis. Schizophrenia Research. 2007;93(1-3):366-373.
Brodeur MB, Lepore F, Lepage M, Bacon BA, Debruille JB. Alternative mode of presentation of Kanizsa figures sheds new light on the chronometry of the neural mechanisms underlying the perception of illusory forms. Neuropsychologia. 2008;46(2):554-66.
Brodeur M, Bacon BA, Renoult L, Prévost M, Lepage M, Debruille JB. On the functional significance of the P1 and N1 effects to illusory figures in the notch mode of presentation. PlosOne. 2008;3(10):e3505.
Debruille JB, Ramirez D, Wolf Y, Schaefer A, Nguyen TV, Bacon BA, Brodeur MB. N400 and knowledge inhibition: a within- and a between-subjects study with distractor words. Brain Research. 2008;1187:167-83.
Debruille JB, Renoult L. Effects of semantic matching and of semantic category on reaction time and N400 that resist numerous repetitions. Neuropsychologia. 2009;47(2):506-17
Debruille JB, Kumar N, Saheb D, Chintoh A, Gharghi D, Lionnet C, King S. Circumventing the deficit of context processing in schizophrenia: An event-related brain potential study. Int. J. of Psychophysiology. 2009. EPub ahead of print.
Renoult L, Debruille JB. N400-like potentials index semantic relations between highly repeated individual words. J. of Cognitive Neuroscience. EPub ahead of print.
Prévost M, Rodier M, Kwann Y, Dionne-Dostie E, Chaplot I, Renoult L, Brodeur M, Lionnet C, Debruille JB. In the general population, N400 amplitude varies with the disorganization and the interpersonal factor of the schizotypal personality questionnaire. Psychophysiology. In press.