A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Dr. SylvainWilliams, PhD
Douglas Mental Health University Institute
6875 LaSalle Blvd
514-761-6131 ext. 5937
Dr. Williams is Associate Professor in psychiatry. His main line of research focuses on how neuronal networks function in the hippocampus, the learning and memory centre of the brain. His work focuses on how a neuronal network can generate brain rhythms important for memory and synaptic plasticity. In addition, he also has an interest in how neuronal networks are perturbed in brain disorders such as Alzheimer’s disease and schizophrenia. Dr. Williams and his team have developed an array of techniques, such as a complete hippocampal structure maintained alive in vitro to perform state-of-the-art electrophysiology and molecular biology. His team is also using a newly developed technique called optogenetics, which offers the unprecedented possibility to manipulate neuronal and network activity with light, using genetically targeted neurons. The general goal of the laboratory is to understand how neurons contribute to brain rhythms and how they are altered in brain diseases.
Undergraduate: BSc, Université de Montréal
Goutagny R, Jackson JJ, Williams S. Self-generated theta oscillations in the hippocampus. Nature Neuroscience. 2009 Dec;12(12):1491-3. See NEWS AND VIEWS: Hippocampal theta rhythms follow the beat of their own drum. By Colgin LL, Moser EI. Nat Neurosci. 2009 Dec;12(12):1483-4.
Manseau F, Goutagny R, Danik M, Williams S. The hippocamposeptal pathway generates rhythmic firing of GABAergic neurons in the medial septum and diagonal bands: an investigation using a complete septohippocampal preparation in vitro. J Neurosci. 2008 Apr 9;28(15):4096-107.
Huh CYL, Danik M, Manseau F, Trudeau L-E, Williams S. Chronic exposure to nerve growth factor increases acetylcholine and glutamate release from cholinergic neurons of the rat medial septum and diagonal band of Broca via mechanisms mediated by p75NTR. J Neurosci. 2008 Feb 6;28(6):1404-9.
Goutagny R, Manseau F, Jackson J, Danik, Williams S. In vitro activation of the medial septum-diagonal band complex generates atropine-sensitive and atropine-resistant hippocampal theta rhythm: an investigation using a complete septohippocampal preparation. Hippocampus. 2008;18(6):531-5.
Lowe G, Danik M, Luhesi GN, Williams S. Prenatal infection and fever are associated with altered glutamatergic synaptic transmission in the hippocampus of juvenile offspring. Am J Physiol Regul Integr Comp Physiol. 2008 Nov;295(5):R1563-71.
Mendez JA, Bourque M-J, Bourdeau ML, Danik M, Williams S, Lacaille JC, Trudeau LE. Contact-dependent regulation of the neurotransmitter phenotype of dopamine neurons. J Neurosci. 2008 Jun 18;28(25):6309-18.
Bhardwaj SK, Baharnoori M, Sharif-Askari B, Kamath A, Williams S, Srivastava LK. Behavioral characterization of dysbindin-1 deficient sandy mice. Behav Brain Res. 2008 Oct 15.
Manseau F, Danik M, Williams S. A functional glutamatergic neurone network in the rat medial septum and diagonal band area. J. Physiol. 2005;566(2).