Dr. Barry. I. Posner (O.C., M.D., F.R.S.C., F.R.C.P.(C), F.A.C.P.)
- Director, polypeptide Hormone Laboratory, McGill University.
- Professor, Department of Medicine, McGill University.
- Associate Member, Department of Physiology, McGill University.
- Associate Member, Department of Chemistry, McGill University.
- Professor, Department of Anatomy and Cell Biology, McGill University.
- Member, Division of Endocrinology, McGill University Hospital Center (M.U.H.C).
- Member, Division of Experimental Medicine, McGill University.
My group has been interested for many years in peptide hormone action. We have focused on the mechanism of cell signalling by insulin and growth factors - especially the insulin-like growth factors (IGFs) and EGF. Six related areas are under investigation:
1. To Assess the Regulation of IRK by Tyrosine Phosphorylation and Dephosphorylation.
2. To Overexpress IRK and Other Signaling Molecules (viz. IRS-1, MAPK) in Vivo in Order to Evaluate Distribution and Function.
3. To Identify and Purify IRK-associated PTP(s).
4. To Prepare and Characterize Novel Peroxovanadium Compounds (pVs) and Explore their Mechanism of Action. Work in this lab since 1987 has led to the identification of a new and powerful class of PTP inhibitors [the peroxovanadium (pV) compounds]. Such inhibition has been shown to result in activation of the IRK and insulin cell signaling both in vitro and in vivo. These agents are being explored both as tools for dissecting insulin action as well as possible clinical use as oral insulin mimetic compounds (ie. oral 'insulin')
5. To Evaluate Signaling Events Consequent to IRK Activation.
6. To Identify the Endosomal Acidic Insulinase (EAI) and Evaluate its Functional Importance. Previous work from this lab has shown that endosomes contain an insulinase which is the likely physiologic degrading enzyme rather than IDE (insulin degrading enzyme).
Lab Manager: Sheryl Jackson
Technicians: Gerry Baquiran; Victor Dumas
Professional Assistants: Catherine Mounier; Alejandro Balbis
Postdoctoral Fellow: Chris Band
Graduate Students: Mei Kong; Chaoyang Li
Left to right (Back): Chaoyang; Victor; Gerry & Chris; (Front): Sheryl; Mei; Catherine & Alejandro
- Mounier, C. et al. (2001). Mol. Cell. Endo. 173:15-27.
- Christine. Lavoie et al. (2000). PNAS. 97: 1363713642.
- Drake, P.G., A. Balbis, J. Wu, J.J.M. Bergeron & B.I. Posner. (2000). Am J Physiol Endo & Met. 279: E266-E274, 2000.
- Balbis, A., G. Baquiran, J.J. M. Bergeron & B.I. Posner. (2000). Endocrinology 141: 4041-4049.
- Kong, M., C. Mounier, J. Wu and B.I. Posner. (2000). J.Biol.Chem. 275: 36035 - 36042.
- Doillon, C.J., R.L.Faure, B.I. Posner & P.E. Savard. (1999). Angiogenesis 3: 361-369.
- Lavoie, L., C. J. Band, M. Kong, J.J.M. Bergeron & B.I. Posner. (1999). J.Biol.Chem. 274: 28279-85.
- Band, C. J., C. Mounier & B.I. Posner. (1999). Endocrinology 140: 5626-5634.