Department of Physiology & Cell Information
Life Sciences Complex (Bellini),
3649 Promenade Sir William Osler
Montréal, Québec H3G 0B1
web site: tba
We are interested in
understanding the molecular bases of mechanotransduction, and the role of
mechanosensory neurons in normal and pathological pain transmission.
Mechanotransduction, the process through which cells convert a mechanical
stimulus into an electrical signal, is of fundamental importance to
physiological functions such as our senses of touch (including pain) and
hearing, as well as our ability to regulate our hydromineral homeostasis
(thirst), baroreflex function and myogenic tone (regulation of blood
pressure). Mechanosensitive ion channels are membrane proteins responsible
for most mechanotransduction processes, yet their molecular identity has not
been fully resolved. Because these channels are involved in several
pathologies of the nervous (chronic pain, deafness) and cardiovascular
(hypertension) systems, the molecular identification of these channels, and
understanding their activation properties may lead to the development of new
therapeutic strategies in several clinical areas.
The projects in the lab focus on
two areas of research:
Identification of the molecular mechanisms underlying neuronal
Identification of central (spinal cord) neuronal circuits engaged by
mechanosensory afferents in control or during chronic pain conditions.
Peyronnet R, Sharif-Naeini R, Folgering JH,
Arhatte M, Jodar M, El Boustany C, Gallian C, Tauc M, Duranton C, Rubera I,
Lesage F, Pei Y, Peters DJ, Somlo S, Sachs F, Patel A, Honoré E, Duprat F.
Mechanoprotection by polycystins against apoptosis is mediated through the
opening of stretch-activated K(2P) channels. Cell Rep. (2012) 1: 241-50.
Bráz JM, Sharif-Naeini R, Vogt D, Kriegstein
A, Alvarez-Buylla A, Rubenstein JL, Basbaum AI. Forebrain GABAergic neuron
precursors integrate into adult spinal cord and reduce injury-induced
neuropathic pain. Neuron (2012) 74: 663-75.
Bohlen CJ, Chesler AT, Sharif-Naeini R,
Medzihradszky KF, Zhou S, King D, Sánchez EE, Burlingame AL, Basbaum AI,
Julius D. A heteromeric Texas coral snake toxin targets acid-sensing ion
channels to produce pain. Nature (2011) 479: 410-4
Sharif-Naeini R, Basbaum AI. Targeting pain where it resides ... In
the brain. Science Transl. Med. (2011) 3: 65ps1.
Sharif-Naeini R, Folgering JH,
Bichet D, Duprat F, Delmas P, Patel A, Honoré E. Sensing pressure in the
cardiovascular system: Gq-coupled mechanoreceptors and TRP channels.
J. Mol. Cell. Cardiol. (2010) 48:
Sharif-Naeini R, Folgering JH,
Bichet D, Duprat F, Lauritzen I, Arhatte M, Jodar M, Dedman A, Chatelain FC,
Schulte U, Retailleau K, Loufrani L, Patel A, Sachs F, Delmas P, Peters DJ,
Honoré E. Polycystin-1 and -2 dosage regulates pressure sensing.
Cell (2009) 139: 587-96.
Sharif-Naeini R, Ciura S,
Bourque CW. TRPV1 gene required for thermosensory transduction and
anticipatory secretion from vasopressin neurons during hyperthermia.
Neuron (2008) 58: 179-85.
Sharif-Naeini R, Dedman A,
Folgering JH, Duprat F, Patel A, Nilius B, Honoré E. TRP channels and
mechanosensory transduction: insights into the arterial myogenic response.
Pflugers Arch. 2008 456: 529-40.
Sharif Naeini R, Witty MF,
Séguéla P, Bourque CW. An N-terminal variant of Trpv1 channel is required
for osmosensory transduction. Nat.
Neurosci. (2006) 9: 93-8.
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