Physiology of Blood
Iron (Fe) is an
essential nutrient required for oxygen transfer, energy production, and cell
growth. While it is necessary for life, it is highly toxic in excess, and
Fe balance in the body must be strictly regulated. Current research focuses
biochemistry and molecular biology of intracellular Fe metabolism, primarily
in immature erythroid cells.
development of new Fe chelating agents for the treatment of Fe overload and
possibly for the management of pathological conditions caused by oxidative
stress. We have identified pyridoxal isonicotinoyl hydrazone (PIH) as an Fe
chelating agent and are developing novel and more effective PIH analogs.
3) Defining the
role of nitric oxide (NO) in cellular Fe metabolism. NO was recently found
to affect an astonishing range of physiological processes, and we have
discovered that NO influences the metabolism of Fe in cells.
Ph.D., Charles University (Prague)
Sheftel AD, Kim
SF, Ponka P
Non-heme induction of heme oxygenase-1 does not alter cellular iron
metabolism. J Biol Chem 282: 10480-10486, 2007.
Zhang A-S, Brown C, Shirihai OS, Ponka P
Direct interorganellar transfer of iron from endosome to mitochondrion.
Blood 110: 125-132, 2007.
Wing S. Ponka P.
Kim S, Wing S,
Ponka P. S-nitrosylation of IRP2 regulates its stability via the ubiquitin-proteasome
pathway. Mol Cell Biol 24:330-337, 2004.
A-S, Sheftel A, Ponka P.
Intracellular kinetics of iron in reticulocytes: evidence for endosome
involvement in iron targeting to mitochondria.
Blood, Jan 1 2005; 105(1):368-75.
Sheftel A, Kim S, Ponka P.
Sheftel AD, Kim SF, Ponka P. Overexpression of mitochondrial ferritin causes
cytosolic iron starvation and changes cellular iron homeostasis. This
article was accompanied by Editorial Commentary by Chitambar CR: Cellular
iron metabolism; Mitochondria in the spotlight. Blood 105, 1844-1845, 2005.
Chen G, Sheftel A, Pantopoulos K, Ponka P.
of mitochondrial ferritin expression on tumor iron metabolism and on tumor
growth in nude mice xenografts. Blood 108: 2428-2434, 2006. This
article was accomplished by Editorial Commentary by Richardson DR, Lovejoy
DR. Iron mining to inhibit tumor growth. Blood 108: 2140, 2006.
Whitnall M, Howard J,
Ponka P, Richardson D..
A class of iron chelators with a wide spectrum of potent antitumor activity
that oversomes resistance to chemotherapeutics. PNAS 2006; 103; 14901-14906
Most of Dr. Ponka's publications can be found at the following web address:
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