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Faculty
& Staff Directory >
Monroe Cohen |
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Department of Physiology
McGill University
McIntyre Medical Sciences Building,
Room 1136
3655 Promenade Sir William Osler
Montréal, Québec H3G 1Y6
(514) 398-4342
monroe.cohen@mcgill.ca |
Research
Area:
Neurophysiology
My research is aimed at understanding how the formation and development of
presynaptic and postsynaptic specializations are regulated during
nerve-muscle synaptogenesis. Currently our focus is on the development and
alignment of presynaptic active zones and postsynaptic junctional folds.
This work is carried out on cultures of embryonic Xenopus nerve and muscle
cells as well as on neuromuscular junctions formed in vivo. Fluorescent
staining and microscopy is used to assess the distribution of the specific
synaptic molecules.
Education: Ph.D., McGill
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Cohen
MW, Moody-Corbett F, Godfrey EW.
Neuritic deposition of agrin on culture substrate: implications for
nerve-muscle synaptogenesis.
J Neurosci. 1994 May;14(5 Pt 2):3293-303.
Cohen
MW, Jacobson C, Godfrey EW, Campbell KP, Carbonetto S.
Distribution of alpha-dystroglycan during embryonic nerve-muscle synaptogenesis.
J Cell Biol. 1995 May;129(4):1093-101.
Cohen
MW, Jacobson C, Yurchenco PD, Morris GE, Carbonetto S.
Laminin-induced clustering of dystroglycan on embryonic muscle cells:
comparison with agrin-induced clustering.
J Cell Biol. 1997 Mar 10;136(5):1047-58.
Cohen MW,
Hoffstrom BG, DeSimone, DW (PDF file)
Active zones on motor nerve terminals contain α3ß1 integrin. J.
Neurosci. 2000 Jul; 20(13): 4912-4921. |
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