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Department of Physiology
McGill University
McIntyre Medical Sciences Building,
Room 1218
3655 Promenade Sir William Osler
Montréal, Québec H3G 1Y6
(514)
398-5709
kathleen.cullen mcgill.ca
Laboratory web site:
http://www.medicine.mcgill.ca/physio/cullenlab/ |
Research
Area: Neurophysiology
An important function of the central nervous
system is to keep track of where we are in relation to where we are going as
we move through our environment. Research in Dr. Cullen's laboratory
explores how cognitive, visual and other inputs are used to generate
internal representation of self motion. The experimental approach is
multidisciplinary and includes recording from individual neurons in the
brain while an alert animal performs a variety of behavioural tasks, as well
as behavioral studies in humans, nonhuman primates, and mice. Neuronal
activity is correlated with various aspects of the orienting behaviour to
further our understanding of how movements of the eyes, head, and body are
coordinated in three dimensional space. Funding for the laboratory is
provided by the National Institutes for Health (NIH), Canadian Institutes
for Health Research, the National Sciences and Engineering Research Council
of Canada, and McGill University.
Education: B.Sc., Brown, Ph.D.,
Chicago
Recent
Publications:
(last 5 years)
Roy J. E. and Cullen K.E.
Selective Processing of Vestibular Reafference during Self Generated
Motion J. Neuroscience, 21: 2131-2142, 2001.
Sylvestre P.A., Galiana H.L., and Cullen K.E.
Conjugate and vergence oscillations
during saccades and gaze shifts: implications for integrated control of
binocular movement. J. Neurophysiol, 87(1):257-72, 2002.
Dubrovsky A.S. and Cullen K.E.
Head, Eye, and Gaze Movement Dynamics During Closed and Open-Loop
Head-unrestrained Pursuit J. Neurophysiol, 87(2):859-75, 2002.
Roy J. E. and Cullen K.E.
Vestibuloocular reflex signal modulation during voluntary and passive
head movements. J. Neurophysiol, 87(5):2337-57, 2002.
Cullen K.E. and Minor L.B.
Semicircular Canal Afferents Similarly Encode Active And Passive
Head-On-Body Rotations: Implications For The Role Of Vestibular
Efference. J. Neuroscience, 22 (RC226): 1-7, 2002.
Huterer M. and Cullen K.E.
Vestibulo-Ocular Reflex Dynamics During High Frequency And High
Acceleration Rotations Of The Head On Body In Rhesus Monkey. J.
Neurophysiol, 88: 13-28, 2002.
Sylvestre P.A. and Cullen K.E.
Dynamics of abducens nucleus neuron discharges during disjunctive
saccades. J. Neurophysiol, 88:3452-68, 2002.
Sylvestre P.A., Choi J.T.L., and Cullen K.E.
Discharge Dynamics of Oculomotor Neural Integrator Neurons During
Conjugate and Disjunctive Saccades and Fixation, J. Neurophysiol ,
90:739-54, 2003.
Roy J. E. and Cullen K.E.
Brainstem pursuit pathways: dissociating visual, vestibular, and
proprioceptive inputs during combined eye-head gaze tracking. J.
Neurophysiol, 90:271-90, 2003.
Roy J. E. and Cullen K.E.
Dissociating Self-Generated from Passively Applied Head Motion: Neural
Mechanisms in the Vestibular Nuclei. J. Neuroscience, 24(9):2102-11,
2004.
McClung J. R., Cullen K. E., Shall M. S., Dimitrova1 D. M., and Goldberg
S. J.
Effects of Electrode Penetrations Into the Abducens Nucleus of the
Monkey: Eye Movement Recordings and Histopathological Evaluation of the
Nuclei and Lateral Rectus Muscles. Exp Brain Res 158(2):180-8, 2004.
Vidal P.-P , Degallaix L. , Josset P., Gasc J.-P., And Cullen K.E.
Postural And Locomotor Control In Normal And Vestibularly Deficient
Mice. J. Physiol. (Lond) 559(Pt 2):625-38, 2004.
Cullen K.E., Huterer M., Braidwood D.A, and Sylvestre P.A.
Time course of vestibulo-ocular reflex suppression during gaze shifts.
J. Neurophysiol. 92(6):3408-22
Cullen K.E and Roy J. E.
Signal Processing in the Vestibular System during Active versus Passive
Head Movements. Invited review: J. Neurophysiol. 91(5):1919-33, 2004.
Cullen K.E.
Sensory signals during active versus passive movement
Invited review: Current Opinion in Neurobiol. 14(6):698-706, 2004.
Pathmanathan J., Presnell R., Cromer J.A, Cullen K.E., and Waitzman D.M.
Spatial characteristics of neurons in the central mesencephalic
reticular formation (cMRF) of head unrestrained monkeys. Exp Brain Res
Nov 15;:1-16, 2005.
Pathmanathan J., Cromer J.A, Cullen K.E., and Waitzman D.M.
Temporal characteristics of neurons in the central mesencephalic
reticular formation (cMRF) of head unrestrained monkeys. Exp Brain Res
Nov 15;:1-22, 2005.
Sylvestre P.A. and Cullen K.E.
Premotor Correlates of Integrated Feedback Control for Eye-Head Gaze
Shifts J. Neuroscience 26: 4922-4929, 2006.
Kathleen Cullen and Soroush Sadeghi
(Web publication in Scholarpedia)
Vestibular
system. Scholarpedia, 3(1):3013,
2008.
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