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Research
Area: Cell
and Molecular Biology
The laboratory has focused since its inception on various
aspects of regulation of gene expression. Much of the work centers on the
role of nuclear receptors in controlling gene transcription. The lab has
been interested in the molecular mechanisms of action of estrogen receptors
(ERs) for several years, and has identified novel coregulatory factors that
control the nuclear and extra-nuclear functions actions of ERs and other
nuclear receptors. The laboratory is also studying the genomics of nuclear
receptor action. The lab is analyzing the potential roles of target genes of
the vitamin
D3 receptor in controlling the growth of cancer cells. We have
identified almost 200 vitamin
D3 target genes in squamous carcinoma cells by
microarray analysis, and are determining the functions of key genes in
regulation of cellular growth and differentiation.
Education: B.Sc.,
M.Sc., Carleton, Ph.D.,
Harvard
Recent
Publications:
(and PDF file links)
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Nuclear
localization of LCoR in MCF-7 cells. |
Prudencio, J. Akutsu, N., Wong, T., Bastien, Y., Lin, R., Black, M.J.,
Alaoui-Jamali, M. and White, J.H. (2001)
Action of low calcemic 1,25-dihydroxyvitamin D3 analog EB1089 in head
and neck squamous cell carcinoma. J. Nat. Cancer Inst. 93,
745-53.
Akutsu, N., Lin, R., Bastien, Y., Bestawros, A., Enepekides, D.J.,
Black, M.J. and White, J.H. (2001)
Regulation of Gene Expression by 1α,25-dihydroxyvitamin D3 and its
Analog EB1089 under Growth Inhibitory Conditions in Squamous Carcinoma
Cells. Mol. Endocrinol. 15, 1127-39.
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Lin, R., Nagai, Y., Sladek, R., Bastien, Y., Ho, J., Petrecca, K.,
Sotiropoulou, G., Diamandis, E.P., Hudson, T., and White J.H. (2002)
Expression profiling in squamous carcinoma cells reveals pleiotropic
effects of vitamin D3 signaling on cell proliferation, differentiation
and immune system regulation. Mol. Endocrinol. 16,
1243-56.
Fernandes, I, Bastien, Y., Wai, T., Nygard, K., Lin, R., Cormier, O.,
Lee, H.S., Eng, F., Bertos, N.R., Pelletier, N., Mader, S., Han
V.K.M., Yang, X.J. and White, J.H. (2003)
Ligand-dependent
corepressor LCoR functions by histone deacetylase-dependent and
–independent mechanisms. Molecular Cell, 11, 139-50.
(Supplemental text & figs;
http://download.molecule.org/pdfs/1097-2765/PIIS1097276503000145.pdf
)
Bourdeau, V.,
Deschenes, J., Metivier, R., Nagai, Y., Nguyen, D.,
Bretschneider, N., Gannon, F., White, J.H. and Mader S.
(2004)
Genome-wide identification of high affinity estrogen
response elements in human and mouse. Mol. Endocrinol.
18, 1411-1427.
Wang, T.T.,
Nestel, F., Bourdeau, V., Nagai, Y., Wang, Q., Wu, J.,
Tavera-Mendoza, L., Lin, R., Hanrahan, J.H., Mader, S. and
White, J.H. (2004)
1,25-dihydroxyvitamin D3 is a direct inducer of
antimicrobial peptide gene expression. J. Immunol.
(Cutting Edge Report). 173, 2909-12.
Wang, T.T., Tavera-Mendoza, L., Laperriere, D., Nagai, Y.,
Burton MacLeod, N., Libby, E., Zhang, R., Bourdeau, V.,
Konstorum, A., Lallemant, B., Mader, S. and White, J.H.
(2005)
Large-scale in silico and microarray-based
genomic screening of 1,25-dihydroxyvitamin D3 target genes.
Mol. Endocrinol. 19, 2685-95.
Tavera-Mendoza, L., Wang, T.T., Lallemant, B., Zhang, R.,
Nagai, Y., Bourdeau, V., Ramiro Calderon, M., Desbarats, J.,
Mader, S., and White, J.H. (2006)
Convergence of vitamin
D and retinoic acid signaling at a common hormone response
element. EMBO Rep. 7, 180-185. (Suppl.
material;
www.nature.com/embor/journal/v7/n2/suppinfo/7400594.html).
Tavera-Mendoza LE, White JH.
Cell
defenses and the sunshine vitamin. Sci Am. 2007 Nov;
297(5):62-5, 68-70, 72.
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