Molecular & Cell Biology
Hematopoiesis and Bone Marrow Function: Molecular Mechanisms Mediating
Resistance to Oxidative Stress and Novel Approaches for Therapeutic
process of hematopoiesis in the bone marrow continuously generates all the
cells of the blood and immune system and its disruption results in severe
and life threatening disorders, including immunodeficiencies, anemias, bone
marrow failures, and malignancies. My research group will investigate the
cellular and molecular mechanisms of hematopoiesis, especially focusing on
the following questions: (i) bone
marrow ageing and the mechanisms mediating the long-term resistance of bone
marrow stem cells to oxidative stress;
(ii) the roles of the H2A-DUB
(histone H2A-deubiquitinase) family of chromatin modifying factors in bone
marrow function and stem cell resistance to oxidative stress;
(iii) development of bioactive
peptides for modulation of hematopoiesis and bone marrow function.
Nijnik A, Woodbine L, Marchetti C, Dawson S, Lambe T, Liu C,
Rodrigues NP, Crockford TL, Cabuy E, Vindigni A, Enver T, Bell JI,
Slijepcevic P, Goodnow CC, Jeggo PA, Cornall RJ. DNA repair is limiting for
hematopoietic stem cells during ageing.
Nijnik A, Dawson S, Crockford T, Woodbine L, Visetnoi S, Bennett S,
Jones M, Turner GD, Jeggo PA, Bell JI, Goodnow CC, Cornall RJ. Impaired
Lymphocyte Development, Class-Switching and Increased Malignancy in a Model
of the DNA Ligase-IV Syndrome.
J Clin Invest.
Nijnik A, Mayer M, Hancock REW. Potential of host defence peptides
as novel anti-infectives.
A, Madera L, Ma S, Waldbrook M, Easton DM, Elliott M,
Kindrachuk J, Jenssen H, Hancock REW. Synthetic
cationic peptide IDR-1002 provides protection against bacterial infections
through chemokine induction and enhanced leukocyte recruitment.
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