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Anmar Khadra
- Assistant Professor
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Department of Physiology
McGill University
McIntyre Medical
Sciences Bldg, rm 1120
3655 Promenade Sir William Osler
Montréal, Québec H3A 1Y6
phone: 514-398-6025 (temp. #)
email:
Anmar.Khadra@mcgill.ca
Laboratory
web site: tba
Postdoctoral
Position Available !!
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Research
Area:
Applied Mathematics
Research
Description:
Understanding various aspects of physiological
phenomena in immunology and endocrinology using computational models
represents the core focus of my current work.
These models provide important insights into the
cellular and molecular processes occurring in these phenomena. Particularly,
I’m interested in examining the role of immune cells, insulin-secreting beta
cells and autoantibodies (via their interaction) in the progression of
autoimmune Type 1 Diabetes, as well as analyzing the molecular mechanisms
(which involve several receptors and ion channels) regulating neuronal
synchrony/rhythmicity and hormone secretion. These projects are conducted in
close collaboration with several, internationally renowned experimentalists.
Beside their valuable relevance to physiology, such models also raise
intriguing mathematical questions and generate very interesting problems
that are either tackled numerically or theoretically using nonlinear
stability analysis. For more details, please visit:
http://itb.biologie.hu-berlin.de/~khadra/
Khadra and Y.X. Li, ``A Model for the Pulsatile Secretion
of Gonadotropin-Releasing Hormone from Synchronized Hypothalamic Neurons'',
Biophysical Journal, 91, 74-83, 2006.
Y.X. Li and A. Khadra, ``Robust Synchrony and
Rhythmogenesis in Endocrine Neurons Via Autocrine Regulations in Vitro and
in Vivo'', Bulletin of Mathematical Biology, 70, 2103-2125, 2008.
A. Khadra, ``Synchrony Due to Parametric Averaging in
Neurons Coupled by a Shared Signal'', Physica D, 238, 771-781, 2009.
A. Khadra, P. Santamaria and L. Edelstein-Keshet, ``The
Role of Low Avidity T Cells in the Protection Against Type 1 Diabetes: A
Modeling Investigation'', Journal of Theoretical Biology, 256, 126-141,
2009.
A. Khadra, P. Santamaria and L. Edelstein-Keshet, ``The
Pathogenicity of Self-Antigen Decreases at High Levels of Autoantigenicity:
A Computational Approach'', International Immunology, 22, 571-582, 2010.
A. Khadra, S. Tsai, P. Santamaria and L.
Edelstein-Keshet, ``On How Monospecific Memory-Like Autoregulatory CD8+
T Cells Can Blunt Diabetogenic Autoimmunity: A Computational Approach'',
Journal of Immunology, 185, 5962-5972, 2010.
Z. Yan*, A. Khadra*, S. Li, M. Tomić., A. Sherman and
S.S. Stojilkovic, ``Experimental Characterization and Mathematical Modeling
of the P2X7 Receptor Channel Gating'', Journal of Neuroscience, 30,
14213-14224, 2010. *Contributed equally to this work.
A. Khadra, M. Pietropaolo, G. T. Nepom and A. Sherman,
``Investigating the Role of T-Cell Avidity and Killing Efficacy in Relation
to Type 1 Diabetes Prediction'', PLoS ONE, 6, e14796, 2011.
Z. Yan, A. Khadra, A. Sherman and S.S. Stojilkovic,
``Calcium-Dependent Block of P2X7 Receptor Channel Function is Allosteric'',
Journal of General Physiology, 138, 437-452, 2011.
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