Department of Physiology, McGill University, Montreal, Quebec, Canada
 



 

 

 

 

 

 

 

RECENT PUBLICATIONS

Hanrahan JW, Sampson HM, Thomas DY. 2013. Novel pharmacological strategies to treat cystic fibrosis. Trends Pharmacol Sci. 34(2):119-25. doi: 10.1016/j.tips.2012.11.006

Sampson HM, Lam H, Chen PC, Zhang D, Mottillo C, Mirza M, Qasim K, Shrier A, Shyng SL, Hanrahan JW, Thomas DY. 2013. Compounds that correct F508del-CFTR trafficking can also correct other protein trafficking diseases: an in vitro study using cell lines. Orphanet J Rare Dis. 8:11. doi: 10.1186/1750-1172-8-11

Carlile GW, Keyzers RA, Teske KA, Robert R, Williams DE, Linington RG, Gray CA, Centko RM, Yan L, Anjos SM, Sampson HM, Zhang D, Liao J, Hanrahan JW, Andersen RJ, Thomas DY 2012. Correction of F508del-CFTR Trafficking by the Sponge Alkaloid Latonduine Is Modulated by Interaction with PARP. Chem Biol. 19(10):1288-99. doi: 10.1016/j.chembiol.2012.08.014

Zhang D, Ciciriello F, Anjos SM, Carissimo A, Liao J, Carlile GW, Balghi H, Robert R, Luini A, Hanrahan JW, Thomas DY 2012. Ouabain mimics low temperature rescue of F508del-CFTR in cystic fibrosis epithelial cells. Frontiers in Pharmacology. 3:176. doi: 10.3389/fphar.2012.00176. Epub 2012 Oct 4

Anjos SM, Robert R, Waller D, Zhang D, Balghi H, Sampson HM, Ciciriello F, Lesimple P, Carlile GW, Goepp J, Liao J, Pasquale F, Phillipe R, Dantzer F, Hanrahan JW, Thomas DY 2012. Decreasing Poly(ADP-ribose) Polymerase activity restores ΔF508 CFTR trafficking. Frontiers in Pharmacology 3:165.

 Veit G, Bossard F, Goepp J, Verkman AS, Galietta LJ, Hanrahan JW, Lukacs GL 2012. Proinflammatory Cytokine Secretion is Suppressed by TMEM16A or CFTR Channel Activity in Human Cystic Fibrosis Bronchial Epithelia. Mol Biol Cell. Sep 12.

 

Huang J, Shan J, Kim D, Liao J, Evagelidis A, Alper SL, Hanrahan JW 2012. Basolateral chloride loading by AE2: Role in fluid secretion by the human airway epithelial cell line Calu-3. J Physiol. Oct 1

 

Shan J, Liao J, Huang J, Robert R, Palmer ML, Fahrenkrug SC, O'Grady SM, Hanrahan JW 2012. Bicarbonate-dependent chloride transport drives fluid secretion by the human airway epithelial cell line Calu-3. J Physiol. ePub Jul 9. In press. See Perspective on the papers by Shan et al. and Huang et al in same issue, Schultz BD 2012. Airway epithelial cells: ’Bicarbonate In’ ≠’Bicarbonate Out’ J PhysiolOct 1

 

Balghi H, Robert R, Rappaz B, Zhang X, Wohlhuter-Haddad A, Evagelidis A, Luo Y, Goepp J, Ferraro P, Roméo P, Trebak M, Wiseman PW, Thomas DY, Hanrahan JW 2011. Enhanced Ca2+ entry due to Orai1 plasma membrane insertion increases IL-8 secretion by cystic fibrosis airways. FASEB J. 25: 4274-4291.

Wine JJ, Joo NS, Choi JY, Cho HJ, Krouse ME, Wu JV, Khansaheb M, Irokawa T, Ianowski J, Hanrahan JW, Cuthbert AW, Tran KV 2011. Measurement of fluid secretion from intact airway submucosal glands. Methods Mol. Biol. 742:93-112.

Sampson HM, Robert R, Liao J, Matthes E, Carlile GW, Hanrahan JW, Thomas DY 2011. Identification of a NBD1-binding pharmacological chaperone that corrects the trafficking defect of F508del-CFTR. Chem Biol. 18(2):231-42.

Shan J, Huang J, Liao J, Robert R and Hanrahan JW 2011. Anion secretion by a model epithelium: more lessons from Calu-3. Acta Physiol.,  Jan 20. doi: 10.1111/j.1748-1716.2011.02253.x..

Robert R, Carlile GC, Liao J, Balghi H, Lesimple P, Liu N, Kus B, Rotin D, Wilke M, de Jonge HR, Scholte BJ, Thomas DY and Hanrahan JW 2010. Correction of {Delta}F508-CFTR trafficking defect by the bioavailable compound glafenine. Mol Pharmacol.,  77:922-930.

LeSimple P, Liao J, Robert R, Gruenert DC and Hanrahan JW 2010. Cystic fibrosis transmembrane conductance regulator trafficking modulates the barrier function of airway epithelial cell monolayers. J Physiol., 588:1195-209.

The cover shows images relating to cystic fibrosis transmembrane conductance regulator (CFTR) trafficking in airway epithelial cells. Upper row, CFBE41o cell immunostained for CFTR and observed by confocal microscopy, and images illustrating the effect of CFTR trafficking on the localization of tight junction proteins (with nuclei shown in blue and ZO-1 in green). Lower three rows, images showing the localisation of adenovirally expressed green fluorescent protein (GFP)–CFTR and GFP–ΔF508–CFTR in epithelial cells (with FM4-64 shown in red and GFP in green). See LeSimple et al. pp. 1195–1209.

Divangahi M, Balghi H, Danialou G, Comtois AS, Demoule A, Ernest S, Haston C, Robert R, Hanrahan JW, Radzioch D and Petrof BJ 2009. Lack of CFTR in skeletal muscle predisposes to muscle wasting and diaphragm muscle pump failure in cystic fibrosis mice. PLoS Genet., Jul;5(7):e1000586. Epub 2009 Jul 31.

Luo Y, McDonald K, Hanrahan JW 2008. Trafficking of immature DeltaF508-CFTR to the plasma membrane and its detection by biotinylation. Biochem J., 419:211-9, 2p following 219.

Michoud MC, Robert R, Hassan M, Moynihan B, Haston C, Govindaraju V, Ferraro P, Hanrahan JW, Martin JG 2009. Role of the ystic fibrosis transmembrane conductance regulator channel in human airway smooth muscle. Am. J. Respir. Cell Mol. Biol., 40:217-22.

Seavilleklein G, Amer N, Evagelidis A, Chappe F, Irvine T, Hanrahan JW, Chappe V 2008. PKC phosphorylation modulates PKA-dependent binding of the R domain to other domains of CFTR. Am. J. Physiol. Cell. Physiol., 295:C1366-75.

Chappe F, Loewen ME, Hanrahan JW, Chappe V 2008. Vasoactive intestinal peptide increases cystic fibrosis transmembrane conductance regulator levels in the apical membrane of Calu-3 cells through a protein kinase C-dependent mechanism. J. Pharmacol. Exp. Ther., 327:226-38.

Wang B, Heath-Engel H, Zhang D, Nguyen N, Thomas DY, Hanrahan JW and Shore GC 2008. BAP31 interacts with Sec61 translocons and promotes retrotranslocation of CFTRDeltaF508 via the derlin-1 complex. Cell, 133:1080-92.

Ianowski JP, Choi JY, Wine JJ and Hanrahan JW 2008. Substance P stimulates CFTR-dependent fluid secretion by mouse tracheal submucosal glands. Pflugers Arch., 457:529-37.

Robert R, Carlile GW, Pavel C, Liu N, Anjos SM, Liao J, Luo Y, Zhang D, Thomas DY and Hanrahan JW 2008. Structural analog of sildenafil identified as a novel corrector of the F508del-CFTR trafficking defect. Mol. Pharmacol., 73:478-89.

REVIEWS

1.   Frizzell, RA & Hanrahan, JW 2012. Physiology of epithelial chloride and fluid secretion. In Cystic Fibrosis: Molecular Basis, Physiological Changes, and Therapeutic strategies," ed. JR Riordan, RC Boucher, and PM Quinton, Cold Spring Harbor Perspect Med 2:a009563

    Hanrahan JW 2008. CFTR-dependent anion transport in airway epithelia.  In Epithelial Transport Physiology, Chapter 5, ed. G.A. Gerenscer, The Humana Press, Totawa, NJ, in press

     Hanrahan JW 2007. CFTR (ABCC7). “Targeted Proteins” Database. Refereed article on a validated drug target, published online by Current BioData Ltd (Swiss-Prot & BioMed Central).

Bates IR, Wiseman PW and Hanrahan JW 2006. Investigating membrane protein dynamics in living cells. Biochem. Cell Biol., 84:825-31.

1.      Hanrahan JW 2005. Fluid and electrolyte transport in the airways. In Physiologic Basis of Pulmonary Diseases, Chapter 38, ed. Q. Hamid, J. Shannon, and J. Martin, BC Decker Inc, Hamilton, ON

 

This page was last edited on 07 May, 2013