FLY NEUROBIOLOGY

Dr. Pejmun Haghighi Lab, Department of Physiology, McGill University

 

 

 

 

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We are interested in understanding the basic molecular mechanisms that regulate synaptic growth, function and plasticity, and how these mechanisms are affected in disease states. For this, we combine genetic and molecular tools with imaging and electrophysiological techniques at the Drosophila neuromuscular junction.

The projects in the lab focus on three areas of research:

1) Signal transduction cascades that control synaptic growth and function via orthograde and retrograde mechanisms.

2) The role of Rho family of GTPases in the regulation of synaptic structure and function.

3) How pre- and post-synaptic regulation of protein translation coordinates synaptic growth and influences neurotransmitter release.