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Physiology 556B Course Information:
Topics In Systems Neuroscience
Course Coordinators
Dr. K. Cullen
Dr. D. Guitton
Aims
1. To provide immediate contact with contemporary systems neuroscience literature thereby leading to insight into: current problems of interest, methodology, and directions for the future.
2. To provide opportunity for extensive discussion on these topics and assigned readings.
3. To promote the capability for critically reading scientific material.
4. To train in presenting orally, materially before others in a coherent fashion.
5. To train in presenting material in written form.
For Whom
- Graduate students with background in neurobiology.
- Honours physiology students and undergraduates with a strong interest in systems neuroscience.
Course Consists Of
- Three (3) hour session to discuss assigned reading (usually 2 full-length scientific papers). Note that no one is assigned a specific paper, but all students participate.
- Paper Critique and Term Paper (see below).
Marking Scheme
- Class participation and presentation, depth of understanding, etc. 50%.
- Critique of a Scientific Paper: Writing Exercise 10%
- Term Paper 40%.
Term Paper
- The following elements are considered important:
a. Structure: presentation and organization;
b. Depth of understanding;
c. Critical examination: correct pick of literature to illustrate problem, evaluation of different contributions to the clarification of the problem being considered, etc.;
d. Ideas of own: originality in approach, selection of ideas, own views, etc.;
e. Figures (cite sources), references, style, grammar.- Term Paper to be handed in on the last meeting of year. If late, deduction of 5% per 3 days.
- Hand in on 2nd Thursday of February a one page proposal including key references.
- Avoid tendency to include every fact available. Do not produce a list of facts or observations. Rather, digest information and present well selected key pieces of the puzzle.
- Choose figures carefully and explain them well in the text, with clear legends, number figures consecutively.
- Suggested length: 20-25 pages double-spaced, excluding single-spaced references and figures.
Please Note:
McGill University values academic integrity. Therefore, all students must understand the meaning and consequences of cheating, plagiarism and other academic offences under the Code of Student Conduct and Disciplinary Procedures (see http://www.mcgill.ca/integrity/studentguide/ for more information).
The Dept. of Physiology will not tolerate any academic offense with regard to cheating and plagiarism. See “Student Rights and Responsibilities” at www.med.mcgill.ca/secretariat/documents for details.
Preliminary Reading
Kandel, Schwartz, Jessell. Principles of Neural Science, Elsevier.
Read sections on Motor, Oculomotor and Visual systems.
556B Topics to be considered
1. Mechanics of eyeball / Discharge characteristics of ocular motoneruons
THE MECHANICS OF HUMAN SACCADIC EYE MOVEMENT
D.A. Robinson.
J. Physiol. (London), 1964, 174:245-264.OCULOMOTOR UNIT BEHAVIOR IN THE MONKEY
D.A. Robinson.
J. Neurophysiol., 1970, 33:393-404.
2. Visuo-oculomotor properties of the superior colliculus
ROLE OF THE ROSTRAL SUPERIOR COLLICULUS IN ACTIVE VISUAL FIXATION AND EXECUTION OF EXPRESS SACCADES. Douglas P. Munoz and Robert H. Wurtz. J. Neurophysiol., 1992, 67(4):1000-1002.
SACCADE-RELATED ACTIVITY IN MONKEY SUPERIOR COLLICULUS. II. SPREAD OF ACTIVITY DURING SACCADES. Douglas P. Munoz and Robert H. Wurtz. J. Neurophysiol., 1995, 73(6):2334-2348.
SEQUENTIAL ACTIVITY OF SIMULTANEOUSLY RECORDED NEURONS IN THE SUPERIOR COLLICULUS DURING CURVED SACCADES. Port NL, Wurtz RH. J Neurophysiol. 2003 Sep;90(3):1887-903
3. Neuronal processing of multimodel sensory information in relation to motor commands
SENSORIMOTOR INTEGRATION IN THE PRIMATE SUPERIOR COLLICULUS. II. COORDINATES OF AUDITORY SIGNALS
Martha F. Jay and David L. Sparks
J. Neurophysiol., 1987, 57(1):35-55.
EYE POSITION INFLUENCES AUDITORY RESPONSES IN PRIMATE INFERIOR COLLICULUS. Groh JM, Trause AS, Underhill AM, Clark KR, Inati S. Neuron. 2001 Feb;29(2):509-18.
REFERENCE FRAMES FOR REPRESENTING VISUAL AND TACTILE LOCATIONS IN PARIETAL CORTEX.
Avillac M, Deneve S, Olivier E, Pouget A, Duhamel JR. Related Articles, Nat Neurosci. 2005 Jul;8(7):941-9.
4. Role of cortex in eye movement control
ROLE OF FRONAL EYE FIELDS IN COUNTERMANDING SACCADES: VISUAL, MOVEMENT, AND FIXATION ACTIVITY
D.P. Hanes, W.F. Patterson II, and J. D. Schall
J. Neurophysiol., 1998, 79:817-834.
WHAT THE BRAIN STEM TELLS THE FRONTAL CORTEX. I. OCULOMOTOR SIGNALS SENT FROM SUPERIOR COLLICULUS TO FRONTAL EYE FIELD VIA MEDIODORSAL THALAMUS.
Sommer MA, Wurtz RH.
J Neurophysiol. 2004 Mar;91(3):1381-402. Epub 2003 Oct 22.
INFLUENCE OF THE THALAMUS ON SPATIAL VISUAL PROCESSING IN FRONTAL CORTEX.
Sommer MA, Wurtz RH.
Nature. 2006 Nov 16;444(7117):374-7.
5. Role of cortex in arm movement control
MOTOR CORTICAL ACTIVITY DURING DRAWING MOVEMENTS: POPULATION REPRESENTATION DURING SINUSOIDAL TRACING.
A.B. Schwartz.
J. Neurophysiol., 1993, 70(1):28-36.
DISSOCIATION BETWEEN HAND MOTION AND POPULATION VECTORS FROM NEURAL ACTIVITY IN MOTOR CORTEX.
S.H. Scott, P.L. Gribble, K.M. Graham, D.W. Cabel,
Nature 2001 Sep 13;413(6852):161-5
COGNITIVE CONTROL SIGNALS FOR NEURAL PROSTHETICS.
Musallam S, Corneil BD, Greger B, Scherberger H, Andersen RA.
Science. 2004 Jul 9;305(5681):258-62.
6. Hippocampus
SINGLE UNIT ACTIVITY IN THE RAT HIPPOCAMPUS DURING A SPATIAL MEMORY TASK
J. O'Keefe and A. Speakman.
Exp. Brain Res., 1987, 68:1-27.PLACE CELLS, HEAD DIRECTION CELLS, AND THE LEARNING OF LANDMARK STABILITY.
Knierim JJ, Kudrimoti HS, McNaughton BL.
J Neurosci. 1995 Mar;15(3 Pt 1):1648-59.
MICROSTRUCTURE OF A SPATIAL MAP IN THE ENTORHINAL CORTEX.
Hafting T, Fyhn M, Molden S, Moser MB, Moser EI.
Nature. 2005 Aug 11;436(7052):801-6. Epub 2005 Jun 19.
7. Visual cortex: I. Structure and function.PRINCIPLES OF NEURAL SCIENCE, Kandel, Schwartz, Jessell. Elsevier. Chapters 28, 29 (Edition 3) or Chapters 26, 27 (Edition 4)
SPATIALLY OPPONENT EXCITATION AND INHIBITION IN SIMPLE CELLS OF THE CAT VISUAL CORTEX.
David Ferster
J. Neurosci., 1988, 8(4):1172-1180.
ORIENTED AXON PROJECTIONS IN PRIMARY VISUAL CORTEX OF THE MONKEY.
L.C. Sincich, G.G. Blasdel.
J Neurosci. 2001 Jun 15;21(12):4416-26.
FUNCTIONAL IMAGING WITH CELLULAR RESOLUTION REVEALS PRECISE MICRO-ARCHITECTURE IN VISUAL CORTEX.
Ohki K, Chung S, Ch'ng YH, Kara P, Reid RC.
Nature. 2005 Feb 10;433(7026):597-603. Epub 2005 Jan 19.
8. Visual cortex: II. Functional pathways.
SEGREGATION OF FORM, COLOR, AND STEREOPSIS IN PRIMATE AREA 18
David H. Hubel and Margaret S. Livingstone.
J. Neurosci., 1987, 7(11):3378-3415.RESPONSES IN MACAQUE VISUAL AREA V4 FOLLOWING INACTIVATION OF THE PARVOCELLULAR AND MAGNOCELLULAR LGN PATHWAYS
Vincent P. Ferrera, Tara A. Nealey, and John H.R. Maunsell.
J. Neurosci., 1994, 14(4):2080-2088.MULTIPLE CIRCUITS RELAYING PRIMATE PARALLEL VISUAL PATHWAYS TO THE MIDDLE TEMPORAL AREA.
Nassi JJ, Callaway EM.
J Neurosci. 2006 Dec 6;26(49):12789-98.
9. "Higher order" visual cortices - Temporal Cortex
VISUAL NEURONES RESPONSIVE TO FACES IN THE MONKEY TEMPORAL CORTEX.
D.I. Perret, E.T. Rolls, and W. Caan.
Exp. Brain Res., 1982, 47: 329-342.
THE FUSIFORM FACE AREA SUBSERVES FACE PERCEPTION, NOT GENERIC WITHIN-CATEGORY IDENTIFICATION.
Grill-Spector K, Knouf N, Kanwisher N.
Nat Neurosci. 2004 May;7(5):555-62. Epub 2004 Apr 11.
A CORTICAL REGION CONSISTING ENTIRELY OF FACE-SELECTIVE CELLS.
Tsao DY, Freiwald WA, Tootell RB, Livingstone MS.
Science. 2006 Feb 3;311(5761):670-4.
10. "Higher order" visual cortices - area MT
THE ANALYSIS OF VISUAL MOTION: A COMPARISON OF NEURONAL AND PSYCHOPHYSICAL PERFORMANCE.
Kenneth H. Britten ,Michael N. Shadlen, William T. Newsome, and J. Anthony Movshon.
J. Neurosci., 1992, 12(12): 4745-4765.
Students need not read in detail the appendix and mathematical model.MICROSTIMULATION IN VISUAL AREA MT: EFFECTS ON DIRECTIONAL DISCRIMINATION PERFORMANCE.
C.D. Salzman , C. M. Murasugi, K.H. Britten, and W.T. Newsome.
J. Neurosci., 1992, 12(6): 2331-2355.
11. "Higher order" visual processing: interpretation of the visual world
TEMPORAL DYNAMICS OF A NEURAL SOLUTION TO THE APERTURE PROBLEM IN VISUAL AREA MT OF MACAQUE BRAIN
Pack CC, Born RT.
Nature. 2001 Feb 22;409(6823):1040-2
DYNAMIC SHAPE SYNTHESIS IN POSTERIOR INFEROTEMPORAL CORTEX.
Brincat SL, Connor CE.
Neuron. 2006 Jan 5;49(1):17-24.
A COMPARISON OF PRIMATE PREFRONTAL AND INFERIOR TEMPORAL CORTICES DURING VISUAL CATEGORIZATION.
Freedman DJ, Riesenhuber M, Poggio T, Miller EK.
J Neurosci. 2003 Jun 15;23(12):5235-46
12. Decision Making
TBA