Brown SE, Fraga MF, Weaver IC, Berdasco M, Szyf M.
Variations in DNA methylation patterns during the cell cycle of HeLa cells.
Epigenetics. 2007 Jan-Mar;2(1):54-65. Epub 2007 Jan 15.
PMID: 17965591
Link
D'Alessio AC, Weaver IC, Szyf M.
Acetylation-induced
transcription is required for active DNA demethylation in
methylation-silenced genes.
Mol Cell Biol. 2007 Nov;27(21):7462-74. Epub 2007 Aug 20.
PMID: 17709385 [PubMed - in process]
Link
Szyf M.
The dynamic epigenome and its implications in toxicology.
Toxicol Sci. 2007 Nov;100(1):7-23. Epub 2007 Aug 3.
PMID: 17675334 Link
Szyf M, Weaver I, Meaney M.
Maternal care, the epigenome and phenotypic differences in behavior.
Reprod Toxicol. 2007 Jul;24(1):9-19. Epub 2007 May 10. Review.
PMID: 17561370 Link
Brown SE, Szyf M.
Epigenetic programming of the rRNA promoter by MBD3.
Mol Cell Biol. 2007 Jul;27(13):4938-52. Epub 2007 Apr 23.
PMID: 17452452 Link
Milutinovic S,
D'Alessio AC, Detich N, Szyf M.
Valproate induces
widespread epigenetic reprogramming which involves
demethylation of specific genes.
Carcinogenesis. 2007 Mar;28(3):560-71. Epub 2006 Sep 28.
PMID: 17012225
Link
Nuyt AM, Szyf M.
Developmental programming through epigenetic changes.
Circ Res. 2007 Mar 2;100(4):452-5. No abstract available.
PMID: 17332436 Link
Weaver IC, D'Alessio AC, Brown SE, Hellstrom IC, Dymov S,
Sharma S, Szyf M,
Meaney MJ.
The transcription factor nerve growth factor-inducible
protein a mediates
epigenetic programming: altering epigenetic marks by immediate-early genes.
J Neurosci. 2007 Feb 14;27(7):1756-68.
PMID: 17301183 Link
Ou JN, Torrisani J, Unterberger A,
Provençal N, Shikimi K, Karimi M, Ekström
TJ, Szyf M.
Histone deacetylase
inhibitor Trichostatin A induces global and gene-specific DNA
demethylation in human cancer cell lines.
Biochem Pharmacol. 2007 May 1;73(9):1297-307. Epub 2007 Jan 5.
PMID: 17276411
Link
Torrisani J, Unterberger A, Tendulkar SR, Shikimi K, Szyf M.
AUF1 cell cycle variations define genomic DNA methylation by regulation of
DNMT1
mRNA stability.
Mol Cell Biol. 2007 Jan;27(1):395-410. Epub 2006 Oct 9.
PMID: 17030625 Link
Unterberger A, Andrews SD, Weaver IC, Szyf M.
DNA methyltransferase 1 knockdown activates a replication stress checkpoint.
Mol Cell Biol. 2006 Oct;26(20):7575-86.
PMID: 17015478
Link
Szyf M.
Targeting DNA methylation in cancer.
Bull Cancer. 2006 Sep 1;93(9):961-72.
PMID: 16980240
Link
D'Alessio AC, Szyf M.
Epigenetic tête-à-tête: the bilateral relationship between chromatin
modifications and DNA methylation.
Biochem Cell Biol. 2006 Aug;84(4):463-76. Review.
PMID: 16936820
Link
Champagne FA, Weaver IC, Diorio J, Dymov S, Szyf M, Meaney MJ.
Maternal care associated with methylation of the estrogen receptor-alpha1b
promoter and estrogen receptor-alpha expression in the medial preoptic area of
female offspring.
Endocrinology. 2006 Jun;147(6):2909-15. Epub 2006 Mar 2.
PMID: 16513834
Link
Zhang TY, Bagot R, Parent C, Nesbitt C, Bredy TW, Caldji C,
Fish E, Anisman
H, Szyf M, Meaney MJ.
Maternal programming of defensive responses through sustained effects on gene
expression.
Biol Psychol. 2006 Jul;73(1):72-89. Epub 2006 Feb 28. Review.
PMID: 16513241
Link
Weaver IC, Meaney MJ, Szyf M.
Maternal care effects on the hippocampal transcriptome and anxiety-mediated
behaviors in the offspring that are reversible in adulthood.
Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3480-5. Epub 2006 Feb 16.
PMID: 16484373
Link
Szyf M.
Therapeutic implications of DNA methylation.
Future Oncol. 2005 Feb;1(1):125-35. Review.
PMID: 16555982
Link
Weaver IC, Champagne FA, Brown SE, Dymov S, Sharma S, Meaney
MJ, Szyf M.
Reversal of maternal programming of stress responses in adult offspring through
methyl supplementation: altering epigenetic marking later in life.
J Neurosci. 2005 Nov 23;25(47):11045-54.
PMID: 16306417
Link
Szyf M, Weaver IC, Champagne FA, Diorio J, Meaney MJ.
Maternal programming of steroid receptor expression and phenotype through DNA
methylation in the rat.
Front Neuroendocrinol. 2005 Oct-Dec;26(3-4):139-62. Epub
2005 Nov 21. Review.
PMID: 16303171
Link
Meaney MJ, Szyf M.
Environmental programming of stress responses through DNA methylation: life at
the interface between a dynamic environment and a fixed genome.
Dialogues Clin Neurosci. 2005;7(2):103-23. Review.
PMID: 16262207
Link
Meaney MJ, Szyf M.
Maternal care as a model for experience-dependent chromatin plasticity?
Trends Neurosci. 2005 Sep;28(9):456-63. Review.
PMID: 16054244
Link
Szyf M.
DNA methylation and demethylation as targets for
anticancer therapy.
Biochemistry (Mosc). 2005 May;70(5):533-49. Review.
PMID: 15948707
Link
Fish EW, Shahrokh D, Bagot R, Caldji C, Bredy T, Szyf M,
Meaney MJ.
Epigenetic Programming of Stress Responses through Variations in Maternal Care.
Ann N Y Acad Sci. 2004 Dec;1036:167-80.
PMID: 15817737
Link
Szyf M, Pakneshan P, Rabbani SA.
DNA methylation and breast cancer.
Biochem Pharmacol. 2004 Sep 15;68(6):1187-97. Review.
PMID: 15313416
Link
Weaver IC, Diorio J, Seckl JR, Szyf M, Meaney MJ.
Early environmental regulation of hippocampal glucocorticoid receptor gene
expression: characterization of intracellular mediators and potential genomic
target sites.
Ann N Y Acad Sci. 2004 Jun;1024:182-212. Review.
PMID: 15265782
Link
Weaver IC, Cervoni N, Champagne FA, D'Alessio AC, Sharma S,
Seckl JR, Dymov
S, Szyf M, Meaney MJ.
Epigenetic programming by maternal behavior.
Nat Neurosci. 2004 Aug;7(8):847-54. Epub 2004 Jun 27.
PMID: 15220929
Link
Szyf M, Pakneshan P, Rabbani SA.
DNA demethylation and cancer: therapeutic implications.
Cancer Lett. 2004 Aug 10;211(2):133-43. Review.
PMID: 15219937
Link
Milutinovic S, Brown SE, Zhuang Q, Szyf M.
DNA methyltransferase 1 knock down induces gene expression by a mechanism
independent of DNA methylation and histone deacetylation.
J Biol Chem. 2004 Jul 2;279(27):27915-27. Epub 2004 Apr 15.
PMID: 15087453
Link
DNA methylation and cancer therapy.
Drug Resist Updat. 2003 Dec;6(6):341-53.
PMID: 14744498
Szyf M
(PDF)
Methylated DNA binding protein 2 antisense inhibitors suppress tumorigenesis of
human cancer lines in vitro and in vivo.
Carcinogenesis. 2003 Dec 19 [Epub ahead of print]
PMID: 14688029 [PubMed - as supplied by publisher]
Campbell PM, Bovenzi V, Szyf M.
(PDF)
Enhanced antitumor
activity of a combination of MBD2-antisense electrotransfer gene therapy and
bleomycin electrochemotherapy.
J Gene Med. 2003 Oct;5(10):893-9.
PMID: 14533198
Ivanov MA, Lamrihi B, Szyf M, Scherman D, Bigey P.
(PDF)
Valproate induces
replication-independent active DNA demethylation.
J Biol Chem. 2003 Jul 25;278(30):27586-92. Epub 2003 May 14.
PMID: 12748177 [PubMed - indexed for MEDLINE]
Detich N, Bovenzi V, Szyf M
(PDF)
Targeting DNA methylation
in cancer.
Ageing Res Rev. 2003 Jul;2(3):299-328.
PMID: 12726777 [PubMed - in process]
Szyf M
(PDF)
The methyl donor S-Adenosylmethionine
inhibits active demethylation of DNA: a candidate novel mechanism for the
pharmacological effects of S-Adenosylmethionine.
J Biol Chem. 2003 Jun 6;278(23):20812-20. Epub 2003 Apr 03.
PMID: 12676953 [PubMed - indexed for MEDLINE]
Detich N, Hamm S, Just K, Knox JD, Szyf M
(PDF)
Epigenomic
stress response: Knock-down of DNA methyltransferase 1 triggers an intra S-phase
arrest of DNA replication and induction of stress response genes.
J Biol Chem. 2003 Feb 7
{Milutinovic S, Zhuang Q, Niveleau A, Szyf M.}
{PDF}
Human DNA
methyltransferase gene DNMT1 is regulated by the APC pathway.
Carcinogenesis. 2003 Jan;24(1):17-24.
{Campbell PM, Szyf M.}
{PDF}
Antisense knock down of MBD2/demethylase inhibits tumorigenesis {Slack A et al., 2002, J Gene Med, 4(4), 381-9} {PDF}
MBD2 demethylase activates and demethylates in a promoter specific manner {Detich N et al., 2002, J Biol Chem, 277(39), 35791-4} {PDF}
Demethylase activity is
directed by chromatin structure {Cervoni N. and Szyf M., 2001, J Biol Chem,
276(44), 40778-87.} {Cervoni N et al., 2002, J Biol Chem, 277(28), 25026-31}
A conserved 3'-untranslated element mediates growth regulation of dna methyltransferase 1 and inhibits its transforming activity {Detich N. et al., 2001, J Biol Chem, 276(27), 24881-24890.} {PDF}
DNMT1 is required for
initiation of DNA replication
{Knox
J. D. et al., 2000, J Biol Chem, 275(24),
17986-17990}
{PDF}
Inhibition of DNMT1
inhibits cancer by a DNA methylation independent mechanism
{Milutinovic
S. et al., 2000, J Biol Chem, 275(9), 6353-9}
{PDF}
Knox JD, Araujo FD, Bigey P, Slack AD, Price GB, Zannis-Hadjopoulos M, Szyf
M.
Inhibition
of DNA methyltransferase inhibits DNA replication.
J Biol Chem. 2000 Jun 16;275(24):17986-90.
PMID: 10849434
Milutinovic S, Knox JD, Szyf M.
DNA
methyltransferase inhibition induces the transcription of the tumor
suppressor p21(WAF1/CIP1/sdi1).
J Biol Chem. 2000 Mar 3;275(9):6353-9.
PMID: 10692435
Bigey P, Ramchandani S, Theberge J, Araujo FD, Szyf M.
Transcriptional
regulation of the human DNA Methyltransferase (dnmt1) gene.
Gene. 2000 Jan 25;242(1-2):407-18.
PMID: 10721735
Bigey P, Knox JD, Croteau S, Bhattacharya SK, Théberge J, Szyf M.
Modified
oligonucleotides as bona fide antagonists of proteins interacting with
DNA. Hairpin antagonists of the human DNA methyltransferase.
J Biol Chem. 1999 Feb 19;274(8):4594-606.
PMID: 9988694
DNA methylation is a reversible biological signal; discovery of DNA demethylase. {Bhattacharya S. K. et al., 1999, Nature, 397(6720), 579-83, Cervoni N. et al., 1999, J Biol Chem, 274(13), 8363-6, Ramchandani S. et al., 1999, Proc Natl Acad Sci U S A, 96(11), 6107-12} {PDF}
Inhibition of DNMT1 inhibits cancer growth, antisense inhibitors of DNMT1 candidate anticancer therapeutics. {MacLeod A. R. and Szyf M., 1995, J Biol Chem, 270(14), 8037-43} {Ramchandani S. et al., 1997, Proc Natl Acad Sci U S A, 94(2), 684-9}
Ras and T antigen
oncogenic pathways induce DNMT1 expression
{MacLeod A. R. et al., 1995, J Biol Chem, 270(19), 11327-37, Rouleau J. et al.,
1995, J Biol Chem, 270(4), 1595-1601} {Slack A. et al., 1999, J Biol Chem,
274(15), 10105-12}
Rouleau J, MacLeod AR, Szyf M.
Regulation
of the DNA methyltransferase by the Ras-AP-1 signaling pathway.
J Biol Chem. 1995 Jan 27;270(4):1595-601.
PMID: 7829490
Szyf M.
DNA
methylation properties: consequences for pharmacology.
Trends Pharmacol Sci. 1994 Jul;15(7):233-8. Review.
PMID: 7940985
Quik M, Odeh R, Philie J, Szyf M.
Functional
nicotinic receptor expression in mesodermal cells transfected with
MyoD cDNA.
Neuroscience. 1993 Dec;57(3):787-95.
PMID: 8309537
Antisense knockdown of DNMT1 induced cellular differentiation {Szyf M. et al., 1992, J Biol Chem, 267(18), 12831-6}
Specific cis acting DNA signals determine DNA methylation patterns {Szyf M. et al., 1990, Mol Cell Biol, 10(8), 4396-400}