PEOPLE

Ryan Martin MSc student

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Education:

I graduated from Western University with a Bachelors of Medical Science in Biochemistry (Honors) in April 2014. Upon completing my undergraduate studies, I began my graduate training under the supervision of Dr. Jason Tanny and Dr. Terry Hébert.

Research:

Phosphorylation of RNA polymerase II (RNAPII) by the cyclin dependent kinase P-TEFb has been shown to be a necessary step in the development of a hypertrophic phenotype in cardiac myocytes. The phosphorylation of RNAPII serves as a scaffold to recruit various factors to the transcription machinery such as chromatin remodeling factors and histone modifying enzymes. My work in the lab focuses on the role P-TEFb has and how various histone modifications are altered in the hypertrophic phenotype using primary rat neonatal cardiomyocytes as a model.