Faculty & Staff   

Building:Bellini
Room: 168
Phone: 514-398-3204
Fax:514-398-2045

E-mail: gerhard.multhaup@mcgill.ca

Research Area:

Neurodegeneration and inflammation
Amyloid toxicity and synaptic plasticity

Research Description:

My research interests are aimed at understanding the molecular, cellular and systemic mechanisms of degenerative nervous system disorders to yield knowledge relevant for the understanding, prevention, and treatment also of other acute and chronic neurological and psychiatric disorders. Research activities will have a focus on basic mechanisms of nervous system function, and will further aim at analyzing critical cascades of neuronal toxicity and at unraveling endogenous neuroprotective mechanisms which may provide a basis for selective therapeutic interventions. Once neuronal toxicity has occurred, the brain utilizes principles of plasticity mechanisms in an attempt to recover function. Therefore, understanding these principles could lead to novel treatment strategies.

Selected Publications:

Mainz A, Bardiaux B, Kuppler F, Multhaup G, Felli IC, Pierattelli R, Reif B. (2012). Structural and mechanistic implications of metal binding in the small heat-shock protein αB-crystallin. J Biol Chem. 287:1128-38.

Dahms SO, Könnig I, Roeser D, Gührs KH, Mayer MC, Kaden D, Multhaup G, Than ME. (2012). Metal Binding Dictates Conformation and Function of the Amyloid Precursor Protein (APP) E2 Domain. J Mol Biol. 416:438-52.

Kaden D, Munter LM, Reif B, Multhaup G. (2012). The amyloid precursor protein and its homologues: Structural and functional aspects of native and pathogenic oligomerization. Eur J Cell Biol. Apr;91(4):234-9.

Resenberger UK, Harmeier A, Woerner AC, Goodman JL, Müller V, Krishnan R, Vabulas RM, Kretzschmar HA, Lindquist S, Hartl FU, Multhaup G, Winklhofer KF, Tatzelt J. (2011). The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication. EMBO J. 30:2057-70.

Kaden D, Harmeier A, Weise C, Munter LM, Althoff V, Rost BR, Hildebrand PW, Schmitz D, Schaefer M, Lurz R, Skodda S, Yamamoto R, Arlt S, Finckh U, Multhaup G. (2012) Novel APP/Aβ mutation K16N produces highly toxic heteromeric Aβ oligomers. EMBO Mol Med. Jul;4(7):647-59.

Hua H, Münter L, Harmeier A, Georgiev O, Multhaup G, Schaffner W. (2011). Toxicity of Alzheimer's disease-associated Aβ peptide is ameliorated in a Drosophila model by tight control of zinc and copper availability. Biol Chem. 392:919-26.

Klose P, Weise C, Bondzio A, Multhaup G, Einspanier R, Gruber AD, Klopfleisch R. (2011). Is there a malignant progression associated with a linear change in protein expression levels from normal canine mammary gland to metastatic mammary tumors? J Proteome Res. 10:4405-15.

Heneka MT, Kummer MP, Weggen S, Bulic B, Multhaup G, Münter L, Hüll M, Pflanzner T, Pietrzik CU. (2011). Molecular mechanisms and therapeutic application of NSAIDs and derived compounds in Alzheimer's disease. Curr Alzheimer Res. 8:115-31. Review.

Kaden D, Bush AI, Danzeisen R, Bayer TA, Multhaup G. (2011). Disturbed copper bioavailability in Alzheimer's disease. Int J Alzheimers Dis. 2011:345614.

Isbert S, Wagner K, Eggert S, Schweitzer A, Multhaup G, Weggen S, Kins S, Pietrzik CU. (2011). APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms. Cell Mol Life Sci. 2011 Nov 22.

Botev A, Munter LM, Wenzel R, Richter L, Althoff V, Ismer J, Gerling U, Weise C, Koksch B, Hildebrand PW, Bittl R, Multhaup G. (2011). The amyloid precursor protein C-terminal fragment C100 occurs in monomeric and dimeric stable conformations and binds γ-secretase modulators. Biochemistry, 50, 828-35.

Richter L, Munter LM, Ness J, Hildebrand PW, Dasari M, Unterreitmeier S, Bulic B, Beyermann M, Gust R, Reif B, Weggen S, Langosch D, Multhaup G. (2010). Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization. Proc Natl Acad Sci U S A, 107, 14597-602.