Research Description:
Bernard Robaire received his BA in Bacteriology from UCLA and his Ph.D. in Pharmacology and Therapeutics from McGill University. After doing a Postdoctoral Fellowship (NIH) at Johns Hopkins University, he returned to McGill in 1977 to take up a joint appointment in the Departments of Pharmacology & Therapeutics and of Obstetrics & Gynecology, where he has remained and is currently a James McGill Professor. In 1993, he was appointed for a five-year period as Associate Vice-Principal (Research) of McGill University. He is currently a member of Senate and President of the McGill Association of University Teachers.
Dr. Robaire’s research interests focus on androgen action, the structure, function and regulation of the epididymis, aging of the male reproductive system, and reproductive toxicology. The results of his research activity have resulted thus far in over 140 journal articles and book chapters, as well as editing or co-editing nine books. Since opening his lab in 1977, his research has been funded continuously by MRC/CIHR, as well as by NIH, FCAR, National Foundation March of Dimes, and the FRSQ. He has served as President of the Canadian Fertility and Andrology Society, the North American Testis Workshop, the American Society of Andrology, and the Association francophone pour le savoir (Acfas).
|
Selected Publications:
(Last three years)
Grenier L, Robaire B, Hales BF. The Activation of DNA Damage Detection and Repair Responses in Cleavage Stage Rat Embryos by a Damaged Paternal Genome. Toxicol Sci. 2012 Mar 27. In Press. PMID: 22454429.
Maselli J, Hales BF, Chan P, Robaire B. Exposure to Bleomycin, Etoposide, and Cis-platinum Alters Rat Sperm Chromatin Integrity and Sperm Head Protein Profile. Biol Reprod. 2012 Mar 8. In Press. PMID: 22402960.
Ernest SR, Wade MG, Lalancette C, Ma YQ, Berger RG, Robaire B, Hales BF. Effects of chronic exposure to an environmentally relevant mixture of brominated flame retardants on the reproductive and thyroid system in adult male rats. Toxicol Sci. 2012 Mar 2. In press. PMID: 22387749.
Piché CD, Sauvageau D, Vanlian M, Erythropel HC, Robaire B, Leask RL. (2012) Effects of di-(2-ethylhexyl) phthalate and four of its metabolites on steroidogenesis in MA-10 cells. Ecotoxicol Environ Saf. 79:108-15.
Larcher S, Delbès G, Robaire B, Yargeau V. (2012) Degradation of 17α-ethinylestradiol by ozonation – Identification of the by-products and assessment of their estrogenicity and toxicity. Environ Int. 39:66‑72.
Delbès G, Yanagiya A, Sonenberg N, Robaire B. (2012) PABP interacting protein 2A (PAIP2A) regulates specific key proteins during spermiogenesis in the mouse. Biol Reprod. 86:95.
Chan D, Delbès G, Landry M, Robaire B, Trasler JM. (2012) Epigenetic alterations in sperm DNA associated with testicular cancer treatment. Toxicol Sci. 125:532-43.
Grenier L, Robaire B, Hales BF. (2011) Paternal cyclophosphamide exposure induces the formation of functional micronuclei during the first zygotic division. PLoS One. 6:e27600.
O’Flaherty CM, Chan PT, Hales BF, Robaire B. (2011) Sperm chromatin structure components are differentially repaired in cancer survivors. J Androl. In press. PMID: 22052778.
Carroll M, Robaire B. (2011) Null mutation of the transcription factor inhibitor of DNA binding 3 (Id3) in male mice adversely impacts on fertility and reproductive outcome. J. Androl. in press. PMID: 22016354.
Paul C, Nagano M, Robaire B. (2011) Aging results in differential regulation of DNA repair pathways in pachytene spermatocytes in the Brown Norway rat. Biol Reprod. 85:1269-78.
Hales BF, Grenier L, Lalancette L, Robaire B. (2011) Epigenetic programming: from gametes to blastocyst. Birth Defects Res A Clin Mol Teratol. 91:652-65.
Hamzeh M, Robaire B. (2011) Androgens Activate Mitogen-Activated Protein Kinase via Epidermal Growth Factor Receptor/Insulin-Like Growth Factor 1 Receptor in the Mouse PC-1 Cell Line. J Endo. 209:55‑64.
Marcon, L., Zhang, X., Hales, B., Robaire, B., and Nagano, M.C. (2011) Effects of Chemotherapeutic Agents for Testicular Cancer on Rat Spermatogonial Stem/Progenitor Cells. J Androl. 32:432-43.
Carroll M, Luu T, Robaire B. (2011) Null mutation of the transcription factor inhibitor of DNA binding 3 (Id3) affects spermatozoal motility parameters and epididymal gene expression. Biol Reprod. 84:765-74.
Yanagiya A, Delbès G, Svitkin YV, Robaire B, Sonenberg N. (2010) The poly(A)-binding protein partner Paip2a controls translation during late spermiogenesis in mice. J Clin Invest. 120:3389‑400.
Hamzeh M, Robaire B. (2010) Identification of early response genes and pathway activated by androgens in the initial segment and caput regions of the regressed rat epididymis. Endocrinology. 151:4504-14.
Marcon L, Zhang X, Hales BF, Nagano MC, Robaire B. (2010) Development of a short-term fluorescence-based assay to assess the toxicity of anticancer drugs on rat stem/progenitor spermatogonia in vitro. Biol Reprod. 83:228-37.
Grenier L, Robaire B, Hales, BF. (2010) Paternal exposure to cyclophosphamide affects the progression of sperm chromatin decondensation and activates a DNA damage response in the prepronuclear rat zygote. Biol Reprod. 83:195-204.
Delbès G, Vaisheva F, Luu T, Marcon L, Hales BF, Robaire B. (2010) Reversibility of the effects of the chemotherapeutic regimen for non-Hodgkin lymphoma, cyclophosphamide, doxorubicin, vincristine, and prednisone, on the male rat reproductive system and progeny outcome. Reprod Toxicol. 29:332‑8.
Barratt CLR, Aitken RJ, de Boer P, Björndahl L, Carrell DT, Perreault SD, Kvist U, Lewis SEM, Perry MJ, Ramos L, Robaire B, Ward S, Zini A. (2010) Sperm DNA: organization, protection and vulnerability: from basic science to clinical applications. A position report. Hum Reprod. 25:824-38.
O’Flaherty C, Hales BF, Chan P, Robaire B. (2010) Impact of chemotherapeutics and advanced testicular cancer or Hodgkin lymphoma on sperm deoxyribonucleic acid integrity. Fertil. Steril. 94:1374-79.
Hamzeh M, Robaire B (2009) Effect of testosterone on epithelial cell proliferation in the regressed rat epididymis. J Androl. 30:200-12.
Delbès G, Chan D, Pakarinen P, Trasler JM, Hales BF, Robaire B. (2009) Impact of the chemotherapy cocktail used to treat testicular cancer on the gene expression profile of germ cells from male Brown-Norway rats. Biol Reprod. 80:320-7.
Tempest HG, Ko E, Rademaker A, Chan P, Robaire B, Martin RH (2009) Intra-individual and inter-individual variations in sperm aneuploidy frequencies in normal men. Fertil Steril. 91:185-92. |
