Faculty & Staff   

Building:McIntyre
Room: 1210
Phone: 514-398-3618
Fax:514-398-8317

E-mail: claudio.cuello@mcgill.ca

Research Description:

Dr Cuello’s lab is interested in degenerative and regenerative processes in the CNS with particular emphasis on aging and Alzheimer’s disease (AD) related studies. His lab utilizes and develops transgenic animal models presenting features of the AD neuropathology. The research is of a multidisciplinary nature ranging from molecular approaches to whole animal experimentation and with a particular interest in Alzheimer’s Therapeutics.
Professor Cuello has been trained at the Universities of Buenos Aires (UBA, Argentina), U. C. San Francisco (USA) and Cambridge (England). He held research and academic positions in the Department of Cell Biology at UBA and in the Department of Pharmacology at both Cambridge and Oxford. He is a past Chair of the McGill Department of Pharmacology and Therapeutics and presently holds the Charles E. Frosst Merck Chair within the same Department. He is also currently an Associate Member of the Departments of Anatomy and Cell Biology and Neurology and Neurosurgery at McGill University, adjunct Professor of the Scripps Institute (LaJolla) and Visiting Professor at Oxford University.

Publications:

Leon WC, Canneva F., Partridge V, Allard S, Ferretti MT, DeWilde A, Vercauteren F., Atifeh R, Ducatenzeiler A, Klein W, Szyf M, Alhonen L, Cuello AC. A novel transgenic rat model with a full Alzheimer’s-like amyloid pathology displays pre-plaque intracellular Aβ-associated cognitive impairment. Journal of Alzheimer’s Disease (in press).

Majdi, M., Ribeiro-da-Silva, A. and Cuello, A.C. (2009) Variations in excitatory and inhibitory postsynaptic protein content in rat cerebral cortex with respect to aging and cognitive status Neuroscience, 159896-907.

Bruno M.A., Leon W.C., Fragoso G., Mushynski W., Almazan G. and Cuello A.C. (2009) Amyloid β-Induced Nerve Growth Factor Dysmetabolism in Alzheimer Disease J Neuropathol Exp Neurol Volume 68, Number 8, August

Cuello, A.C. and Canneva, F. (2008) Impact of intracellular Aβ in transgenic animals and cell models
Neurodegenerative Diseases, Special Edition 5 (3-4): 146-148

Bell, K.F.S., Zheng, L., Fahrenholz, F. and Cuello, A.C. (2008) ADAM-10 over-expression increases cortical synaptogenesis. Neurobiology of Aging 29: 554-565

Bell, K.F.S. and Cuello, A.C. (2008) Augmentation paradoxale du nombre de synapses glutamatergiques lors des troubles cognitifs légers de la maladie d’Alzheimer. Nouvelles indd. M/S no 6-7, vol. 24, juin-juillet

A.C. Cuello, Editor, “Pharmacological Mechanisms in Alzheimer's Therapeutics” Springer, New York (2008).

Costa-Mattioli, M., Gobert, D., Stern, E., Gamache, K., Colina, R., Cuello, A.C., Sossin, W., Kaufman, R., Pelletier, J., Rosenblum, K., Krnjevic, K., Lacaille, J.-C., Nader, K., Sonenberg, N. (2007) eIF2a phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory Cell, 129: 195–206

Arvanitis, C.N., Ducatenzeiler, A., Ou, J.N., Grodstein, E., Andrews, S.D., Tendulkar S.R., Ribeiro-da-Silva, A., Szyf, M. , Cuello, A.C (2007) High intracellular concentrations of Amyloid-Beta block nuclear translocation of phosphorylated CREB. Journal of Neurochemistry, 103(1): 216-228.

Cuello, A.C., Bruno, M.A, and Bell, K.F.S (2007) NGF-cholinergic dependency in brain aging, MCI and Alzheimer’s disease. Current Alzheimer Research, 4(4): 351-358.

Cuello, A.C. and Bruno, M.A. (2007) The failure in NGF maturation and its increased degradation as the probable cause for the vulnerability of cholinergic neurons in Alzheimer's disease. Neurochemical Research, 32 (6): 1041-1045.

Bell, K.F.S., Bennett, D.A. and Cuello, A.C. (2007) Paradoxical upregulation of glutamatergic presynaptic boutons during mild cognitive impairment. Journal of Neuroscience 27(4): 10810-10817.

Majdi, M., Ribeiro-da-Silva, and Cuello, A.C. (2007) Cognitive impairment and transmitter specific pre- and post-synaptic changes in the rat cerebral cortex during aging. European Journal of Neuroscience 26(12): 3583-3596.

Cuello, A.C., Canneva, F. (2007) Impact of intracellular Aβ in transgenic animals and cell models. Neurodegenerative Diseases, 5: 146-148.

Bruno, M.A. and Cuello, A.C., (2006) Activity-dependent release of precursor nerve growth factor, conversion to mature nerve growth factor, and its degradation by a protease cascade. PNAS, 103(17): 6735-40. (2007 Theodore Sourkes Prize, McGill Dept. of Pharmacology)

Bell, K.F.S., Ducatenzeiler, A., Ribeiro-da-Silva, A., Duff, K., Bennett, D.A. and Cuello, A.C. (2006) The amyloid pathology progresses in a neurotransmitter-specific manner. Neurobiology of Aging, 27: 1644-1657.

Bell, K.F.S. and Cuello, A.C., (2006) Altered synaptic function in Alzheimer's disease. European Journal of Pharmacology, 545: 11-21.

Echeverria, V., Ducatenzeiler, A., Chen, C.H., and Cuello, A.C., (2005) Endogenous Abeta peptide synthesis modulates CRE-regulated gene expression in PC12 cells. Neuroscience, 135: 1193-1202.

Cuello, A.C. (2005) Intracellular and extracellular Abeta, a tale of two neuropathologies. Brain Pathol, 15(1): 66-71.