Laboratory of Cellular and Molecular Neuroscience
Synaptic Activity in AII Amacrine Cells
iGluR Structures
Antibody Staining of the Rat Retina
GABA Receptor Structure
iGluR Single Channels
NaV-Ab Structure
Spikes in cerebellar stellate cells
iGluR Drug Discovery
GABA Receptors in Human Epilepsy
AMPARs in Glaucoma
Sodium Currents
Single Channel iGluRs
AMPAR Signaling Complex
Research Interests
The Bowie Lab uses a combination of techniques to study ionotropic glutamate receptors (iGluRs), GABA-A receptors and more recently, Na+ channels. All ion-channel families are widespread in the vertebrate brain and fulfill many important roles in healthy individuals as well as being implicated in disease states associated with postnatal development (e.g. Autism, Schizophrenia), cerebral insult (e.g. Stroke, Epilepsy) and aging disorders (e.g. Alzheimer's disease, Parkinsonism). We are looking at iGluRs, GABA-A receptors and Na+ channels at two inter-related levels. In molecular terms, we are examining the events that occur when each ion-channel family is activated with the aim of developing novel therapeutic compounds. At the cellular level, we are studying the role that iGluRs, GABA-A receptors and Na+ channels fulfill in shaping the behaviour of neuronal circuits and how these processes may be corrected in disease states.
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Important Links
Lab news
February 2024 - Congratulations to Xin-tong and Federico on their new paper published in Nature Structural and Molecular Biology! Read about how this work furthers our understanding of calcium-permeable AMPARs in the McGill Newsroom.
Many congratulations as well to former trainee Dr. Amanda Perozzo for her publication in JBC!
December 2023 - Read about Amanda's scientific journey in this month's IPN Neuroblog.
November 2023 - The lab congradulates Amanda Perozzo in succesfully crossing the finish line of her PhD!
October 2023 - The lab publishes in Nature Communications! Kudos to first author, Amanda, and co-authors, Drs. Jochen Schwenk and Aichu Kamalova from the Fakler and Nakagawa groups, respectively. Teamwork makes the dream work
Derek and Fede attended the 5th European GRIN Conference in Barcelona, Spain. Learn more about GRIN Europe here.
Join the lab
We currently have positions available for graduate students and/or post-doctoral fellows. Click the link above for more information!
Find out more about us by looking us up on the NeuroTree