Dr. Cuello's Research Laboratory


Department of Pharmacology and Therapeutics, McGill University



Complete list of Publications

Most Recent Publications: 

*Iulita MF, Ganesh A, *Pentz R, *Flores Aguilar L, *Gubert P, *Ducatenzeiler A, Christie S, Wilcock GK, Cuello AC. (2019) Identification and Preliminary Validation of a Plasma Profile Associated with Cognitive Decline in Dementia and At-Risk Individuals: A Retrospective Cohort Analysis. J Alzheimers Dis. 2019;67(1):327-341. doi: 10.3233/JAD-180970.PubMed

Hampel H, Mesulam MM, Cuello AC, Khachaturian AS, Vergallo A, Farlow MR, Snyder PJ, Giacobini E, Khachaturian ZS. (2019)  Revisiting the Cholinergic Hypothesis in Alzheimer's Disease: Emerging Evidence from Translational and Clinical Research. J Prev Alzheimers Dis. 2019;6(1):2-15. doi: 10.14283/jpad.2018.43.PubMed

*Foret MK, *Do Carmo S, Lincoln R, Greene LE, Zhang W, Cuello AC, Cosa G. (2018) Effect of antioxidant supplements on lipid peroxidation levels in primary cortical neuron cultures.Free Radic Biol Med. 130:471-477. PubMed

 *Welikovitch LA, *Do Carmo S, Maglóczky Z, Szocsics P, Lőke J, Freund T, Cuello AC.(2018) Evidence of intraneuronal Aβ accumulation preceding tau pathology in the entorhinal cortex. Acta Neuropathol. 2018 PubMed

Prestia FA, Galeano P, Martino Adami PV, *Do Carmo S, Castaño EM, Cuello AC, Morelli L.(2018) Platelets Bioenergetics Screening Reflects the Impact of Brain Aβ Plaque Accumulation in a Rat Model of Alzheimer.Neurochem Res. 2018  PubMed

Cavedo E, Chiesa PA, Houot M, Ferretti MT, Grothe MJ, Teipel SJ, Lista S, Habert MO, Potier MC, Dubois B, Hampel H; INSIGHT-preAD Study Group; Alzheimer Precision Medicine Initiative (APMI). (2018) Sex differences in functional and molecular neuroimaging biomarkers of Alzheimer's disease in cognitively normal older adults with subjective memory complaints. Alzheimers Dement. 14(9):1204-1215. Review.PubMed

*Wilson EN, *Do Carmo S, *Iulita MF, *Hall H, Austin GL, Jia DT, *Malcolm JC, *Foret MK, *Marks AR, Butterfield DA, Cuello AC. (2018) Microdose Lithium NP03 Diminishes Pre-Plaque Oxidative Damage and Neuroinflammation in a Rat Model of Alzheimer's-like Amyloidosis. Curr Alzheimer Res. 15(13):1220-1230. PubMed

Vergallo A, Bun RS, Toschi N, Baldacci F, Zetterberg H, Blennow K, Cavedo E, Lamari F, Habert MO, Dubois B, Floris R, Garaci F, Lista S, Hampel H; INSIGHT-preAD study group; Alzheimer Precision Medicine Initiative (APMI). (2018) Association of cerebrospinal fluid α-synuclein with total and phospho-tau181 protein concentrations and brain amyloid load in cognitively normal subjective memory complainers stratified by Alzheimer's disease biomarkers. Alzheimers Dement. 2018 PubMed

Hampel H, Mesulam MM, Cuello AC, Farlow MR, Giacobini E, Grossberg GT, Khachaturian AS, Vergallo A, Cavedo E, Snyder PJ, Khachaturian ZS.(2018) The cholinergic system in the pathophysiology and treatment of Alzheimer's disease. Brain. 141(7):1917-1933 PubMed

*Allard S, *Jacobs ML, *Do Carmo S, Cuello AC (2018) Compromise of cortical proNGF maturation causes selective retrograde atrophy in cholinergic nucleus basalis neurons. Neurobiol Aging.; 67: 10-20. PubMed

Galeano P, Leal MC, Ferrari CC, Dalmasso MC, Martino Adami PV, Farías MI, Casabona JC, Puntel M, *Do Carmo S, Smal C, Arán M, Castaño EM, Pitossi FJ, Cuello AC, Morelli L.(2018) Chronic Hippocampal Expression of Notch Intracellular Domain Induces Vascular Thickening, Reduces Glucose Availability, and Exacerbates Spatial Memory Deficits in a Rat Model of Early Alzheimer. Mol Neurobiol. 55(11):8637-8650.PubMed

Qi Y, Klyubin I, Cuello AC, Rowan MJ (2018) NLRP3-dependent synaptic plasticity deficit in an Alzheimer's disease amyloidosis model in vivo. Neurobiol Dis. 114:24-30. PubMed

Hampel H, Vergallo A, Aguilar LF, Benda N, Broich K, Cuello AC, Cummings J, Dubois B, Federoff HJ, Fiandaca M, Genthon R, Haberkamp M, Karran E, Mapstone M, Perry G, Schneider LS, Welikovitch LA, Woodcock J, Baldacci F, Lista S.(2018) Precision pharmacology for Alzheimer's disease Alzheimer Precision Medicine Initiative (APMI) Pharmacol Res. 2018 Feb 16. [Epub ahead of print] Review. PubMed

*Hall H, *Iulita MF, *Gubert P, *Flores Aguilar L, *Ducatenzeiler A, Fisher A, Cuello AC. (2018)  AF710B, an M1/sigma-1 receptor agonist with long-lasting disease-modifying properties in a transgenic rat model of Alzheimer’s disease. Alzheimer’s and Dementia. 14(6):811-823 PubMed

Parent MJ, Zimmer ER, Shin M, Kang MS, Fonov VS, Mathieu A, Aliaga A, Kostikov A, *Do Carmo S, Dea D, Poirier J, Soucy JP, Gauthier S, Cuello AC, Rosa-Neto P. (2017) Multimodal imaging in rat model recapitulates Alzheimer's Disease biomarkers abnormalities. J Neurosci. 1346-17. doi: 10.1523/JNEUROSCI.1346-17.2017. [Epub ahead of print] PubMed

Caraci F, *Iulita MF, *Pentz R, *Flores Aguilar L, *Orciani C, Barone C, Romano C, Drago F, Cuello AC. (2017)Searching for new pharmacological targets for the treatment of Alzheimer's disease in Down syndrome.Eur J Pharmacol. 817:7-19. PubMed

Cuello AC. (2017) Early and Late CNS Inflammation in Alzheimer's Disease: Two Extremes of a Continuum? Trends Pharmacol Sci. 38(11):956-966. Epub Review. Impact Factor: 10.148 PubMed

*Iulita MF, *Bistué Millón MB, *Pentz R, *Aguilar LF, *Do Carmo S, *Allard S, Michalski B, *Wilson EN, *Ducatenzeiler A, Bruno MA, Fahnestock M, Cuello AC. (2017) Differential deregulation of NGF and BDNF neurotrophins in a transgenic rat model of Alzheimer's disease. Neurobiol Dis. 108:307-323. doi: 10.1016/j.nbd.2017.08.019. Epub PubMed

*Wilson EN, *Do Carmo S, Iulita MF, *Hall H, *Ducatenzeiler A, *Marks AR, *Allard S, Jia DT, *Windheim J, Cuello AC.(2017) BACE1 inhibition by microdose lithium formulation NP03 rescues memory loss and early stage amyloid neuropathology. Transl Psychiatry. 7(8):e1190. doi: 10.1038/tp.2017.169. PubMed

*Do Carmo S, Crynen G, Paradis T, Reed J, *Iulita MF, *Ducatenzeiler A, Crawford F, Cuello AC. (2017) Hippocampal Proteomic Analysis Reveals Distinct Pathway Deregulation Profiles at Early and Late Stages in a Rat Model of Alzheimer's-Like Amyloid Pathology. Mol Neurobiol. doi: 0.1007/s12035-017-0580-9.  PubMed

Zhang D, Qi Y, Klyubin I, Ondrejcak T, Sarell CJ, Cuello AC, Collinge J, Rowan MJ. (2017) Targeting glutamatergic and cellular prion protein mechanisms of amyloid β-mediated persistent synaptic plasticity disruption: Longitudinal Studies. Neuropharm. 121:231-246. doi: 10.1016/j.neuropharm.2017.03.036.  PubMed

Martino Adami PV, Galeano P, Wallinger ML, Quijano C, Rabossi A, Pagano ES, Olivar N, Reyes Toso C, Cardinali D, Brusco LI, *Do Carmo S, Radi R, Gevorkian G, Castaño EM, Cuello AC, Morelli L. (2017) Worsening of memory deficit induced by energy-dense diet in a rat model of early-Alzheimer's disease is associated to neurotoxic Aβ species and independent of neuroinflammation. Biochim Biophys Acta. 1863(3):731-743. doi: 10.1016/j.bbadis.2016.12.014. Epub 2016 Dec 27 PubMed

Grégoire S, Millecamps M, Naso L, *Do Carmo S, Cuello AC, Szyf M, Stone LS. (2017) Therapeutic benefits of the methyl donor S-adenosylmethionine on nerve injury-induced mechanical hypersensitivity and cognitive impairment in mice.Pain. 158(5):802-810. doi: 10.1097/j.pain..PubMed

*Wilson EN, Abela AR, *Do Carmo S, *Allard S, *Marks AR, *Welikovitch LA, *Ducatenzeiler A, Chudasama Y, Cuello AC. (2017) Intraneuronal Amyloid Beta Accumulation Disrupts Hippocampal CRTC1-Dependent Gene Expression and Cognitive Function in a Rat Model of Alzheimer Disease. Cereb Cortex. 27(2):1501-1511. PubMed

Martino Adami PV, Quijano C, Magnani N, Galeano P, Evelson P, Cassina A, *Do Carmo S, Leal MC, Castaño EM, Cuello AC, Morelli L. (2017) Synaptosomal bioenergetic defects are associated with cognitive impairment in a transgenic rat model of early Alzheimer's disease.J Cereb Blood Flow Metab. 37(1):69-84. Epub 2015 Nov 9. PubMed

Do Carmo S*, Hanzel CE*, Jacobs ML*, Machnes Z, Iulita MF*, Yang J, Yu L, Ducatenzeiler A*, Danik M*, Breuillaud LS*, Bennett DA, Szyf M, Cuello AC.(2016) Rescue of Early bace-1 and Global DNA Demethylation by S-Adenosylmethionine Reduces Amyloid Pathology and Improves Cognition in an Alzheimer's Model .Sci Rep. 6:34051-34068. PubMed

Iulita MF, Ower A, Barone C, Pentz R, Gubert P, Romano C, Cantarella RA, Elia F, Buono S, Recupero M, Romano C, Castellano S, Bosco P, Di Nuovo S, Drago F, Caraci F, and Cuello AC. An inflammatory and trophic disconnect biomarker profile revealed in Down syndrome plasma: Relation to cognitive decline and longitudinal evaluation. Alzheimers Dement. 2016 Jul 21. pii: S1552-5260(16)30037-1. [Epub ahead of print]. PMID: 27452424. PubMed

Wilson EN, Abela AR, Do Carmo S, Allard S, Marks AR, Welikovitch LA, Ducatenzeiler A, Chudasama Y and Cuello AC. Intraneuronal Amyloid Beta Accumulation Disrupts Hippocampal CRTC1-Dependent Gene Expression and Cognitive Function in a Rat Model of Alzheimer Disease. Cerebral Cortex. (2016). [Epub ahead of print]. PMID: 26759481. PubMed

Martino Adami PV, Quijano C, Manani N, Galeano P, Evelson P, Caddina A, Do Carmo S, Leal MC, Castano EM, Cuello AC and Morelli L. Synaptosomal bioenergetic defects are associated with cognitive impairment in a transgenic rat model of early Alzheimer's disease. Journal of Cerebral Blood Flow and Metabolism (2015); Nov 9. [Epub ahead of print]. PubMed

Iulita MD and Cuello AC. The NGF Metabolic Pathway in the CNS and its Dysregulation in Down Syndrome and Alzheimer's Disease. Current Alzheimer Research. (2016);13(1):53-67. PMID: 26391047. PubMed

Pimentel LS, Allard S,, Do Carmo S, Weinreb O, Danik M, Hanzel CE, Youdim MB and Cuello AC. The Multi-Target Drug M30 Shows Pro-Cognitive and Anti-Inflammatory Effects in a Rat Model of Alzheimer's Disease. Journal of Alzheimer's Disease 2015;47(2):373-83. PubMed

Qi Y, Klyubin I, Harney SC, Hu N, Cullen WK, Grant MK, Steffen J, Wilson EN, Do Carmo S, Remy S, Fuhrmann M, Ashe KH, Cuello AC and Rowan MJ. Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aβ-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: rapid reversal by anti-Aβ agents. Acta Neuropathologica Communications 2014 Dec 24;2:175. doi: 10.1186/s40478-014-0175-x. PubMed

Iulita MF, Allard S, Richter L, Münter LM, Ducatenzeiler A, Weise C, Do Carmo S, Klein WL, Multhaup G and Cuello AC. Intracellular Aβ Pathology and Early Cognitive Impairments in a Transgenic Rat Model Overexpressing Human Amyloid Precursor Protein: a Multidimensional Study. Acta Neuropathologica Communications 2014 Jun 5;2:61. PubMed

Iulita MF and Cuello AC. Nerve growth factor metabolic dysfunction in Alzheimer’s disease and Down’s syndrome. Trends in Pharmacological Sciences 2014 Jul;35(7):338-48. PubMed

Hanzel CE, Pichet-Binette A, Pimentel LS, Iulita MF, Allard S, Ducatenzeiler A, Do Carmo S, Cuello AC. Neuronal driven pre-plaque inflammation in a transgenic rat model of Alzheimer's disease. Neurobiol Aging. 2014 Mar 28. pii: S0197-4580(14)00283-8. PubMed

Iulita MF, Do Carmo S, Ower AK, Fortress AM, Flores Aguilar,L, Hanna M, Wisniewski T, Granholm AC, Buhusi M, Busciglio J, Cuello A.C. Nerve growth factor metabolic dysfunction in Down's syndrome brains. Brain. 2014 Mar;137(Pt 3):860-72 PubMed .

Hanzel CE, Iulita MF, Eyjolfsdottir E, Hjorth E, Schutzberg M, Eriksdotter M and Cuello AC. Analysis of matrix metallo-proteases and the plasminogen system in Mild Cognitive Impairment and Alzheimer’s disease cerebro-spinal fluid. J Alzheimers Dis. 2014 Jan 1;40(3):667-78 PubMed

Do Carmo S, Cuello A.C. (2013) Modeling Alzheimer's disease in transgenic rats, Molecular Neurodegeneration, 2013 Oct. 25; 8(1): 1-11. PubMed

Osikowicz M, Longo G, Allard S, Cuello A.C, Ribeiro-da-Silva A. (2013) Inhibition of endogenous NGF degradation induces mechanical allodynia and thermal hyperalgesia in rats, Molecular Pain, 2013 June 29; 9(1):1-13 PubMed

Cuello, A.C, Allard S, Ferretti MT (2012) Evidence for the accumulation of Abeta immunoreactive material in the human brain and in transgenic animal models. Life Sci. 91:1141-1147.PubMed

Bruno MA and Cuello, A.C (2012) Cortical peroxynitration of nerve growth factor in aged and cognitively impaired rats. Neurobiol Aging. 33:1927-1937. PubMed

Ferretti MT, Allard S, Partridge V, Ducatenzeiler A, Cuello, A.C (2012) Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology. J Neuroinflammation 9:62-70. PubMed

Allard S, Leon WC, Pakavathkumar P, Bruno MA, Ribeiro-da-Silva A, Cuello, A.C  (2012) Impact of the NGF maturation and degradation pathway on the cortical cholinergic system phenotype. J Neurosci. 32:2002-2012. PubMed

Cuello, A.C, Ferretti MT, Iulita MF (2012) Preplaque ('preclinical') Aβ-induced inflammation and nerve growth factor deregulation in transgenic models of Alzheimer's disease-like amyloid pathology. Neurodegener Dis. 10:104-107. PubMed

Ferretti MT and Cuello, A.C. (2011) Does a pro-inflammatory process precede Alzheimer's disease and mild cognitive impairment? Current Alzheimer Research, 8:164-74.

Ferretti MT, Bruno MA, Ducatenzeiler A, Klein WL, Cuello, A.C (2011) Intracellular Abeta-oligomers and early inflammation in a model of Alzheimer's Disease.  Neurobiol of Aging Jul 33:1329-1342. PubMed

Ferretti MT, Partridge V, Leon WC, Canneva F, Allard S, Arvanitis DN, Vercauteren F, Houle D, Ducatenzeiler A, Klein WL, Glabe CG, Szyf M, Cuello, A.C. (2011). Transgenic Mice as a Model of Pre-Clinical Alzheimer's Disease.  Current Alzheimer Research 8:4-23. PubMed

Allard S, Scardochio T, Cuello, A.C., Ribeiro-da-Silva A. (2010) Correlation of cognitive performance and morphological changes in neocortical pyramidal neurons in aging. Neurobiol of Aging 33:1466-1480.   PubMed

Leon WC, Bruno MA, Allard S, Nader K, Cuello, A.C. (2010) Engagement of the PFC in consolidation and recall of recent spatial memory. Learn Mem. 17:297-305. PubMed

Leon WC, Canneva F, Partridge V, Allard S, Ferretti MT, de Wilde A, Vercauteren F, Atifeh R, Ducatenzeiler A, Klein W, Szyf M, Alhonen L and Cuello, A.C. (2010) A Novel Transgenic Rat Model with a Full Alzheimer's-Life Amyloid Pathology Displays Pre-Plaque Intracellular Amyloid-beta-Associated Cognitive Impairment. Journal of Alzheimer's disease 20:113-126. PubMed

Cuello, A.C., Ferretti M.T., Leon W.C., Iulita M.F., Melis T., Ducatenzeiler A. (2010) Early-stage inflammation and experimental therapy in transgenic models of the Alzheimer-like amyloid pathology. Neuro-degenerative Dis 7:96-98. PubMed

Cuello, A.C., Bruno M.A., Allard S., Leon W., Iulita M.F. (2010) Cholinergic Involvement in Alzheimer's Disease: A Link with NGF Maturation and Degradation. J. Mol Neurosci. 40:230-235.PubMed

Bruno MA, Mufson EJ, Wu J and Cuello, A.C. (2009) Increased Matrix Metalloproteinase 9 Activity in Mild Cognitive Impairment. J Neuropath Exp Neurol. Vol 68, Number 12. 1309-18 PubMed

Bruno, M.A., Leon, W.C., Fragoso, G., Mushynski, W.E., Almazan, G., Cuello, A.C. (2009) Aβ-induced NGF dysmetabolism in Alzheimer’s disease. Journal of Neuropathology and Experimental Neurology, 10:807-809. (This work is the first demonstration that the NGF trophic disconnect in Alzheimer’s disease is due to compromise of the NGF metabolism) PubMed