Selected Publications:

Allard S, Gosein, V. Cuello A.C. and Ribeiro-da-Silva A. (2010) Changes with aging in the dopaminergic and noradrenergic innervation of rat neocortex . Neurobiology of Aging. (in press)

Cuello , A.C., Ferretti , M.T., Leon, W.C., Iulita, M.F., Melis, T., Ducatenzeiler, A., Bruno, M.A. and Canneva, F. (2009) Early stage inflammation and experimental therapy in transgenic models of the Alzheimer-like amyloid pathology. Neurodegenerative Diseases. (accepted for publication)

Cuello AC, Bruno MA, Allard S, Leon W, Iulita MF. (2010) Cholinergic involvement in Alzheimer's disease. A link with NGF maturation and degradation. J Mol Neurosci. Jan;40(1-2):230-5.

Leon WC, Canneva F., Partridge V, Allard S, Ferretti MT, DeWilde A, Vercauteren F., Atifeh R, Ducatenzeiler A, Klein W, Szyf M, Alhonen L, Cuello AC. A novel transgenic rat model with a full Alzheimer’s-like amyloid pathology displays pre-plaque intracellular Aβ-associated cognitive impairment. Journal of Alzheimer’s Disease (in press).

Majdi, M., Ribeiro-da-Silva, A. and Cuello, A.C. (2009) Variations in excitatory and inhibitory postsynaptic protein content in rat cerebral cortex with respect to aging and cognitive status Neuroscience, 159896-907.

Bruno M.A., Leon W.C., Fragoso G., Mushynski W., Almazan G. and Cuello A.C. (2009) Amyloid β-Induced Nerve Growth Factor Dysmetabolism in Alzheimer Disease J Neuropathol Exp Neurol Volume 68, Number 8, August

Cuello, A.C. and Canneva, F. (2008) Impact of intracellular Aβ in transgenic animals and cell models
Neurodegenerative Diseases, Special Edition 5 (3-4): 146-148

Bell, K.F.S., Zheng, L., Fahrenholz, F. and Cuello, A.C. (2008) ADAM-10 over-expression increases cortical synaptogenesis. Neurobiology of Aging 29: 554-565

Bell, K.F.S. and Cuello, A.C. (2008) Augmentation paradoxale du nombre de synapses glutamatergiques lors des troubles cognitifs légers de la maladie d’Alzheimer. Nouvelles indd. M/S no 6-7, vol. 24, juin-juillet

A.C. Cuello, Editor, “Pharmacological Mechanisms in Alzheimer's Therapeutics” Springer, New York (2008).

Costa-Mattioli, M., Gobert, D., Stern, E., Gamache, K., Colina, R., Cuello, A.C., Sossin, W., Kaufman, R., Pelletier, J., Rosenblum, K., Krnjevic, K., Lacaille, J.-C., Nader, K., Sonenberg, N. (2007) eIF2a phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory Cell, 129: 195–206

Arvanitis, C.N., Ducatenzeiler, A., Ou, J.N., Grodstein, E., Andrews, S.D., Tendulkar S.R., Ribeiro-da-Silva, A., Szyf, M. , Cuello, A.C (2007) High intracellular concentrations of Amyloid-Beta block nuclear translocation of phosphorylated CREB. Journal of Neurochemistry, 103(1): 216-228.

Cuello, A.C., Bruno, M.A, and Bell, K.F.S (2007) NGF-cholinergic dependency in brain aging, MCI and Alzheimer’s disease. Current Alzheimer Research, 4(4): 351-358.

Cuello, A.C. and Bruno, M.A. (2007) The failure in NGF maturation and its increased degradation as the probable cause for the vulnerability of cholinergic neurons in Alzheimer's disease. Neurochemical Research, 32 (6): 1041-1045.

Bell, K.F.S., Bennett, D.A. and Cuello, A.C. (2007) Paradoxical upregulation of glutamatergic presynaptic boutons during mild cognitive impairment. Journal of Neuroscience 27(4): 10810-10817.

Majdi, M., Ribeiro-da-Silva, and Cuello, A.C. (2007) Cognitive impairment and transmitter specific pre- and post-synaptic changes in the rat cerebral cortex during aging. European Journal of Neuroscience 26(12): 3583-3596.

Cuello, A.C., Canneva, F. (2007) Impact of intracellular Aβ in transgenic animals and cell models. Neurodegenerative Diseases, 5: 146-148.

Bruno, M.A. and Cuello, A.C., (2006) Activity-dependent release of precursor nerve growth factor, conversion to mature nerve growth factor, and its degradation by a protease cascade. PNAS, 103(17): 6735-40. (2007 Theodore Sourkes Prize, McGill Dept. of Pharmacology)

Bell, K.F.S., Ducatenzeiler, A., Ribeiro-da-Silva, A., Duff, K., Bennett, D.A. and Cuello, A.C. (2006) The amyloid pathology progresses in a neurotransmitter-specific manner. Neurobiology of Aging, 27: 1644-1657.

Bell, K.F.S. and Cuello, A.C., (2006) Altered synaptic function in Alzheimer's disease. European Journal of Pharmacology, 545: 11-21.

Echeverria, V., Ducatenzeiler, A., Chen, C.H., and Cuello, A.C., (2005) Endogenous Abeta peptide synthesis modulates CRE-regulated gene expression in PC12 cells. Neuroscience, 135: 1193-1202.

Cuello, A.C. (2005) Intracellular and extracellular Abeta, a tale of two neuropathologies. Brain Pathol, 15(1): 66-71.