Dr. Cuello's Research Laboratory

 

Department of Pharmacology and Therapeutics, McGill University
 

 

Publications

Complete list of Publications (PDF)

Selected Publications:

Iulita MF, Do Carmo S, Ower AK, Fortress AM, Flores Aguilar,L, Hanna M, Wisniewski T, Granholm AC, Buhusi M, Busciglio J, Cuello A.C. (2014) Nerve growth factor metabolic dysfunction in Down's syndrome brains. Accepted for publication in Brain (in press).

Hanzel CE, Iulita MF, Eyjolfsdottir E, Hjorth E, Schutzberg M, Eriksdotter M and Cuello AC (2014) Analysis of matrix metallo-proteases and the plasminogen system in Mild Cognitive Impairment and Alzheimer’s disease cerebro-spinal fluid. Accepted for publication in The Journal of Alzheimer’s Disease (in press).

Do Carmo S, Cuello A.C. (2013) Modeling Alzheimer's disease in transgenic rats, Molecular Neurodegeneration, 2013 Oct. 25; 8(1): 1-11.

Osikowicz M, Longo G, Allard S, Cuello A.C, Ribeiro-da-Silva A. (2013) Inhibition of endogenous NGF degradation induces mechanical allodynia and thermal hyperalgesia in rats, Molecular Pain, 2013 June 29; 9(1):1-13

Cuello, A.C, Allard S, Ferretti MT (2012) Evidence for the accumulation of Abeta immunoreactive material in the human brain and in transgenic animal models. Life Sci. 91:1141-1147.

Bruno MA and Cuello, A.C (2012) Cortical peroxynitration of nerve growth factor in aged and cognitively impaired rats. Neurobiol Aging. 33:1927-1937.

Ferretti MT, Allard S, Partridge V, Ducatenzeiler A, Cuello, A.C (2012) Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology. J Neuroinflammation 9:62-70.

Allard S, Leon WC, Pakavathkumar P, Bruno MA, Ribeiro-da-Silva A, Cuello, A.C  (2012) Impact of the NGF maturation and degradation pathway on the cortical cholinergic system phenotype. J Neurosci. 32:2002-2012.

Cuello, A.C, Ferretti MT, Iulita MF (2012) Preplaque ('preclinical') Aβ-induced inflammation and nerve growth factor deregulation in transgenic models of Alzheimer's disease-like amyloid pathology. Neurodegener Dis. 10:104-107.

Ferretti MT and Cuello, A.C. (2011) Does a pro-inflammatory process precede Alzheimer's disease and mild cognitive impairment? Current Alzheimer Research, 8:164-74.

Ferretti MT, Bruno MA, Ducatenzeiler A, Klein WL, Cuello, A.C (2011) Intracellular Abeta-oligomers and early inflammation in a model of Alzheimer's Disease.  Neurobiol of Aging Jul 33:1329-1342.

Ferretti MT, Partridge V, Leon WC, Canneva F, Allard S, Arvanitis DN, Vercauteren F, Houle D, Ducatenzeiler A, Klein WL, Glabe CG, Szyf M, Cuello, A.C. (2011). Transgenic Mice as a Model of Pre-Clinical Alzheimer's Disease.  Current Alzheimer Research 8:4-23.

Allard S, Scardochio T, Cuello, A.C., Ribeiro-da-Silva A. (2010) Correlation of cognitive performance and morphological changes in neocortical pyramidal neurons in aging. Neurobiol of Aging 33:1466-1480.  

Leon WC, Bruno MA, Allard S, Nader K, Cuello, A.C. (2010) Engagement of the PFC in consolidation and recall of recent spatial memory. Learn Mem. 17:297-305.

Leon WC, Canneva F, Partridge V, Allard S, Ferretti MT, de Wilde A, Vercauteren F, Atifeh R, Ducatenzeiler A, Klein W, Szyf M, Alhonen L and Cuello, A.C. (2010) A Novel Transgenic Rat Model with a Full Alzheimer's-Life Amyloid Pathology Displays Pre-Plaque Intracellular Amyloid-beta-Associated Cognitive Impairment. Journal of Alzheimer's disease 20:113-126.

Cuello, A.C., Ferretti M.T., Leon W.C., Iulita M.F., Melis T., Ducatenzeiler A. (2010) Early-stage inflammation and experimental therapy in transgenic models of the Alzheimer-like amyloid pathology. Neuro-degenerative Dis 7:96-98.

Cuello, A.C., Bruno M.A., Allard S., Leon W., Iulita M.F. (2010) Cholinergic Involvement in Alzheimer's Disease: A Link with NGF Maturation and Degradation. J. Mol Neurosci. 40:230-235.

Bruno MA, Mufson EJ, Wu J and Cuello, A.C. (2009) Increased Matrix Metalloproteinase 9 Activity in Mild Cognitive Impairment. J Neuropath Exp Neurol. Vol 68, Number 12. 1309-18

Bruno, M.A., Leon, W.C., Fragoso, G., Mushynski, W.E., Almazan, G., Cuello, A.C. (2009) Aβ-induced NGF dysmetabolism in Alzheimer’s disease. Journal of Neuropathology and Experimental Neurology, 10:807-809. (This work is the first demonstration that the NGF trophic disconnect in Alzheimer’s disease is due to compromise of the NGF metabolism)

Madji, M., Ribeiro-da-Silva, and Cuello, A.C. (2009) Variations in excitatory and inhibitory postsynaptic protein content in rat cerebral cortex with respect to aging and cognitive status. Neuroscience 159:896-907.
 
Bell, K.F.S., Zheng, L., Fahrenholz, F. and Cuello, A.C. (2008) ADAM-10 over-expression increases cortical synaptogenesis. Neurobiology of Aging, 29: 554-565.

Cuello, A.C. and Canneva, F. (2008) Impact of intracellular Aβ in transgenic animals and cell models Neurodegenerative Diseases, Special Edition 5 (3-4): 146-148

A.C. Cuello, Editor, “Pharmacological Mechanisms in Alzheimer's Therapeutics” Springer, New York (2008).

Costa-Mattioli, M., Gobert, D., Stern, E., Gamache, K., Colina, R., Cuello, A.C., Sossin, W., Kaufman, R., Pelletier, J., Rosenblum, K., Krnjevic, K., Lacaille, J.-C., Nader, K., Sonenberg, N. (2007) eIF2a phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory Cell, 129: 195–206