Dr. Cuello's Research Laboratory


Department of Pharmacology and Therapeutics, McGill University


Lab Group

Fabio Canneva


  • Genova, Italy


  • I completed my PhD studies in Genetics and Molecular Biology, at University of Pavia, Department of Genetics and Microbiology, on January 2005. My thesis project (Structural characterization and functional analysis of Rv2358-furB operon from Mycobacterium tuberculosis) was aimed to investigate the transcriptional regulation of the Rv2358-furB operon from Mycobacterium tuberculosis, encoding for two putative transcritpional regulators involved in metal homeostasis . Part of the work was financed by the 'Young Researcher Program' opened for PhD students of the University of Pavia.

  • My bachelor program, at University of Genova, focused on Molecular Biology and was completed with a Master thesis (October 2001) with the following title ‘Cloning, expression and purification of the human histone H4, and structural characterization’.

Research Interests:

  • Alzheimer’s Disease, Neurosciences, Molcular Biology.

Current projects:

  • I’ve worked in the past two years at the characterization of a novel rat model of Alzheimer’s disease, in which the accumulation of soluble forms of the Amyloid Beta peptide (Aβ) is associated with spatial learning and memory impairments. I also developed stably transfected cell lines carrying the human Amyloid Precursor Protein (APP), from which Aβ is generated, either in the wt or AD-linked mutated form. I’m currently working at defining the causality between soluble Aβ accumulation and the dysregulation of signaling cascades involved in the memory formation and retrieval processes.

Extracurricular Interests and Activities:

  • Extreme shopping, such as finding stylish shoes in North America….