Dr. Cuello's Research Laboratory


Department of Pharmacology and Therapeutics, McGill University


Dr. A. Claudio Cuello, M.D., D.Sc., FRSC, OC

Dr. Claudio Cuello is the Charles E. Frosst/Merck Chair in Pharmacology and past Head of the Department of Pharmacology and Therapeutics at McGill University, Montreal, Canada. He leads a research team working on the multidisciplinary aspects of brain repair, brain aging and cellular and molecular neuropathology of Alzheimer’s disease. Dr Cuello is an author of more than 300 peer reviewed scientific publications, edited several books in his field and is on the editorial boards of numerous journals in the Neurosciences. He is a past Staff Scientist of the Cambridge MRC-NCP Unit and past Professor in Neuropharmacology at Oxford University. Dr. Cuello graduated in Medicine in 1965 from the University of Buenos Aires, Argentina and in 1986 was granted a D.Sc degree by Oxford University for outstanding contributions to Neuroscience. He has been named Honorary Professor at the School of Biochemistry and Pharmacy, Buenos Aires University and received an Honorary Doctorate in Sciences from the University of Ceara, Brazil and an Honorary Doctorate in Medicine from Kuopio University, Finland. He has been elected Fellow of the Royal Society of Canada and has received the Novartis Senior Award of the Pharmacological Society of Canada, the H. Lehman Award from the Canadian College of NeuroPsychopharmacology and has been named “Highly Cited Neuroscientist” by the ISI (Institute of Scientific Information, USA). He is presently an Adjunct Professor in Neuropharmacology at the Scripps Institute, La Jolla (CA) and Visiting Professor at the Departments of Pathology and Pharmacology at Oxford University.

The Lab Scientific Genealogical Tree

Dr Cuello was trained in histology in the laboratory of Dr Eduardo De Robertis (discoverer of synaptic vesicles)at the Institute of Cell Biology, Faculty of Medicine, Buenos Aires University (Argentina) while he was still a medical student. At the same Institute he was trained in electron microscopy and initial neuropharmacology studies with Amanda Pellegrino de Iraldi, who in turn was trained by Pio Del Rio Hortega, the discoverer of microglia who was one of the most outstanding disciples of Ramon y Cajal (Nobel laureate 1906) . Dr Cuello was trained at the same Institute in human neuroanatomy by Dr. Fernando Orioli, a disciple of Mettler, a classical USA neuroanatomist. Later, he acquired expertise in experimental endocrinology with a Houssay disciple (Nobel Laureate 1947) Dr Umberto Tramezzani, at the Institute of Neurobiology, Buenos Aires (Argentina). He spent two years of further postdoctoral training in the Physiology of the hypothalamic-pituitary axis combining neuropharmacology and neurochemistry with Dr William F Ganong (author of the Review of Medical Physiology 20th, 21st and 22nd ed. by The McGraw-Hill Companies, Inc. 2001, 2003, 2005). His last postdoctoral stint was done at the MRC (Medical Research Council of Britain) Neurochemical Pharmacology Unit in Cambridge (England) under the leadership of Leslie Iversen. During that year he incorporated a number of biochemical pharmacology approaches and developed one of the first highly sensitive radioenzymatic techniques for the measurement of catecholamines.

The most influential and inspirational influences during the formative years were those of Eduardo De Robertis, William F Ganong and Leslie Iversen.

On his return from England, he accepted a year’s stint as Assistant Professor in Argentina at the Faculty of Pharmacy and Biochemistry, only to return in 1975 to the Cambridge MRC Neurochemical Pharmacology Unit as MRC Scientific Staff where he remained until 1978 when he was offered a joint Academic position at Oxford University (England) to be held at the Departments of Pharmacology and of Human anatomy along with the E.P. Abraham Senior Research Fellowship and Medical Tutor position at Lincoln College (funded in 1427 by the Bishop of Lincoln). From this position he came to Canada invited to Chair the Department of Pharmacology and Therapeutics at McGill University a position he held from 1985 until the year 2000, to soon accede to the Charles E. Frosst/Merck Chair in Pharmacology. From the Cambridge, Oxford and McGill positions he trained a long list of excellent Graduate Students and Post-Doctoral fellows who became leaders in their fields. The listings of the mentoring influences and that of the trainees are represented graphically below

Genealogy Tree (PPT)

Further details of Dr. Cuello’s life experience and of his academic and scientific evolution until the year 2000 can be found in a publication sponsored by the Society for Neuroscience: “The History of Neuroscience in Autobiography” (Ed. L. Squires, Academic Press, NY, 2001).

Link here to The History of Neuroscience in Autobiography
From Volume 3: Autobiographical Essay on Dr. Cuello (pdf)