Philip  Branton


Oncology; Biochemistry

Gilman Cheney Chair in Biochemistry
Fellow of the Royal Society of Canada

Department of Biochemistry
McIntyre Medical Building
Room 701
3655 Promenade Sir William Osler
Montreal, QC H3G 1Y6

Telephone: (514) 398-8350

Education: Ph.D., M.Sc., B.Sc., University of Toronto

Research Focus: Adenoviruses; Apoptosis; Cell Death; Signal Transduction; Cell Cycle Regulation.

Recent Presentations:

CIHR Originals Meeting (Banff, AB) Feb 28-Mar 2, 2014 “Hot Topics in Cancer Research” (invited plenary talk)

IARC Meeting on Emerging Oncogenic Viruses, Madurna Italy, Jun 4-8, 2014 “A new role for the human Ad5 E4orf6/E1B55K E3 ubiquitin ligase complex and implications for human cancer“ (invited plenary talk)

DNA Tumor Virus Meeting, Madison WI Jul 21-26, 2014 “The human adenovirus type 5 E4orf4 protein targets two phosphatase regulators of the Hippo signaling pathway in inducing tumor cell-specific death” (plenary talk)

Recent Publications:

Sriskandarajah N, Blanchette P, Kucharski TJ, Teodoro JG, Branton PE. Analysis by Live Imaging of Effects of the Adenovirus E4orf4 Protein on Passage through Mitosis of H1299 Tumor Cells. J Virol. 2015 Apr 15;89(8):4685-9. doi: 10.1128/JVI.03437-14. Epub 2015 Feb 4.

Wimmer P, Berscheminski J, Blanchette P, Groitl P, Branton PE, Hay RT, Dobner T, Schreiner S.PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53. Oncogene. 2015 Mar 16. doi: 10.1038/onc.2015.63. [Epub ahead of print]

Gilson, T., C.Y Cheng, W.S. Hur, P. Blanchette and P.E. Branton. 2014. Analysis of the Cullin Binding Sites of the E4orf6 Proteins of Human Adenovirus E3 Ubiquitin Ligases. J. Virol. 88, 3885-3897.

Lu Y, Kucharski TJ, Gamache I, Blanchette P, Branton PE, Teodoro JG. 2014. Interaction of adenovirus type 5 E4orf4 with the nuclear pore subunit Nup205 is required for proper viral gene expression. J. Virol. 88, 13249-13259.