Philip  Branton


Oncology; Biochemistry

Gilman Cheney Professor of Biochemistry

Department of Biochemistry
McIntyre Medical Building
Room 701
3655 Promenade Sir William Osler
Montreal, QC H3G 1Y6

Telephone: (514) 398-8350

Education: Ph.D., M.Sc., B.Sc., University of Toronto

Research Focus: Adenoviruses; Apoptosis; Cell Death; Signal Transduction; Cell Cycle Regulation.

Recent Presentations:

Mechanism of action of the adenovirus death protein. FASEB Summer Research Conferences (Protein Phosphatases), Snowmass, CO, July 15-20, 2006.

Localization and functions of adenovirus E4orf4 virus mutants. DNA Tumor Virus Meeting 2006. The Salk Institute, La Jolla CA. July 11-14, 2006.

Human adenovirus E4orf4 protein induces premature mitotic arrest by a PP2A-dependant mechanism leading to cell death in Saccharomyces cerevisiae Signal Transduction Meeting, Banff Alberta, March 3 - 7, 2006.

RBP1 family proteins exhibit SUMOylation-dependant transcriptional repression and induce cell growth inhibition reminiscent of senescence. Signal Transduction Meeting, Banff Alberta, March 3 - 7, 2006.

Recent Publications:

LI, S., A. Szymborski, M.J. Miron, R.C. Marcellus, O. Binda, J. N. Lavoie and Philip E. Branton.
The adenovirus E4orf4 protein induces growth arrest and mitotic catasptrophe in H1299 human lung carcinoma cells. Oncogene.2009; 28: 390-400. (on-line Oct. 2008)

Dallaire F, Blanchette P, Groitl P, Dobner T, Branton PE.
Identification of Integrin {alpha}3 as a New Substrate of the Adenovirus E4orf6/E1B55K E3 Ubiquitin Ligase Complex.J Virol. 2009 Mar 18.

Miron MJ, Blanchette P, Groitl P, Dallaire F, Teodoro JG, Li S, Dobner T, Branton PE
Localization and importance of the adenovirus E4orf4 protein during lytic infection.J Virol. 2009 Feb;83(4):1689-99. Epub 2008 Dec 10.

Blanchette P, Branton PE.
Manipulation of the ubiquitin-proteasome pathway by small DNA tumor viruses.Virology. 2009 Feb 20;384(2):317-23. Epub 2008 Nov 14. Review.

Smadja-Lamère N, Boulanger MC, Champagne C, Branton PE, Lavoie JN.
JNK-mediated phosphorylation of paxillin in adhesion assembly and tension-induced cell death by the adenovirus death factor E4orf4.J Biol Chem. 2008 Dec 5;283(49):34352-64. Epub 2008 Sep 25.

Branton, P.E
Cancer research in Canada: What should drive the research agenda.  The Lancet Oncology.2008; 9: 82-83. 

BINDA, O., C, Nassif, and P.E. Branton.
SIRT1 negatively regulates HDAC1-dependent transcriptional repression by the RBP1 family of proteins. Oncogene. 2008; 27:3384-3392. 

Blanchette P, Kindsmüller K, Groitl P, Dallaire F, Speiseder T, Branton PE, Dobner T.
Control of mRNA export by adenovirus E4orf6 and E1B55K proteins during productive infection requires E4orf6 ubiquitin ligase activity. J Virol. 2008 Mar;82(6):2642-51.

Branton PE.
Does Canadian research investment relate to cancer burden? Lancet Oncol. 2008 Feb;9(2):82-3.