Nephrogenic and Neurogenic Diabetes Insipidus
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AVPR2

3-D model of the human arginine vasopressin (AVP) receptor (V2), which is encoded by the AVPR2 gene, with the AVP hormone docked into the putative active site.  Side view from a direction parallel to the cell membrane surface. The transmembrane helices are shown in red, the intracellular and extracellular loops are shown in blue. The model is oriented such that the extracellular side is at the top of  the image.  The positioning of the transmembrane domains 1-7 is counterclockwise when viewed from the extracellular surface of  the receptor.     This image was derived from the structure of the 3-D model of the V1a receptor described by B. Mouillac et al (1995).   The image was produced using the MidasPlus program from the Computer Graphics Laboratory, University of California, San Francisco (supported by NIH RR-01081).  [B. Mouillac et al, Journal of Biological Chemistry 270:25771-25777, 1995; Y. Ala et al., Journal of the American Society of Nephrology 9:1861-1872, 1998].

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