Telephone: (514) 987-5561
Projects for Thesis
1. Evaluation of the role of the adaptor
molecule EAT-2 in macrophages and dendritic cells, using an
EAT-2-deficient mouse generated in our laboratory.
2. Examination of the mechanism by which SAP, a
small adaptor molecule mutated in X-linked lymphoproliferative disease
in humans, regulates immune responses.
3. Characterization of the role and mechanism
of action of SLAM family receptors in immune cells.
Zhang, S., Shi, X., Dong, Z., Davidson, D. and Zhong, M.-C.
SAP expression in T cells, not in B cells, is required for humoral
immunity. Proc. Natl. Acad. Sci. In Press, 2008.
Dong, Z. and Latour, S. (2007)
Consequence of the SLAM-SAP signaling pathway in innate-like and
conventional lymphocytes. Immunity 27: 698-710.
Davidson, D., Schraven, B. and
Veillette, A. (2007)
PAG-associated FynT regulates calcium signaling and promotes anergy in T
lymphocytes. Mol. Cell. Biol. 27: 1960-1973.