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Contact
information:
Telephone: (514) 398-4259
e-mail address: peter.siegel@mcgill.ca
website:
http://www.medicine.mcgill.ca/biochem/siegellab/
Projects for Thesis
Supervision:
1. Identification of molecular mediators of
breast cancer metastasis to distinct organs and tissues.
2. Co-Operation between TGF-β and ErbB-2
pathways in breast cancer progression.
3. Mechanisms promoting breast cancer
metastasis – Role of EMT?
4. Tumor cell host interactions: Communication
between breast cancer cells and bone-resorbing osteoclasts
Recent
Publications:
Gupta GP, Minn AJ, Kang Y,
Siegel PM, Serganova I, Cordon-Cardo
C, Olshen AB, Gerald WL, Massagué
J.
Identifying Site-specific Metastasis Genes and Functions. Cold Spring
Harb Symp Quant Biol. 70:1-10, 2005.
Minn AJ, Gupta GP,
Siegel PM, Bos PD, Shu W,
Giri DD, Viale A, Olshen AB, Gerald WL, Massagué,
J.
Genes that mediate breast cancer metastasis to lung. Nature, 436:
518-524, 2005.
Siegel PM, Massagué J.
Cytostatic and apoptotic actions of TGF-b in homeostasis and cancer. Nat
Rev Cancer, 3: 807-820, 2003.
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