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Contact
information:
Telephone: (514) 398-3864, ext.
094148
e-mail address: simon.rousseau@mcgill.ca
website:
http://simonrousseau-research.mcgill.ca/
http://meakins.mcgill.ca/rousseau.php
Projects for Thesis
Supervision:
1. Dynamic activation of intracellular
signaling pathways in the host-pathogen interaction.
2. Mechanism of action of the IL-17 receptor
family in driving inflammation in the lungs.
3. Mechanism of action of the p38 MAPK pathway
in driving inflammation in response to Pseudomonas aeruginosa in cystic
fibrosis patients.
Recent
Publications:
Roussel, L., Houle, F., Chan, C. Yao, Y.,
Berube, J., Olivenstein, R., Martin, J.G., Huot, J., Hamid, Q., Ferri,
L. and Rousseau, S.
IL-17
promotes p38 MAPK-dependent endothelial activation enhancing neutrophil
recruitment in vivo. J. Immunol. In Press.
Roussel, L. and
Rousseau, S.
(2009)
IL-17 primes airway epithelial cells lacking functional cystic fibrosis
transmembrane conductance regulator (CFTR) to increase NOD1 responses.
Biochem. Biophys. Res. Commun. 391: 505-509.
Berube, J., Bourdon, C., Yao, Y. and
Rousseau, S.
(2009)
Distinct intracellular signaling pathways control the synthesis of IL-8
and RANTES in TLR1/TLR2, TLR3 or NOD1 activated human airway epithelial
cells. Cellular Signalling 21: 448-456.
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