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Janusz Rak >






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Associate Professor Department of Pediatrics

Associate Member Department of Medicine, Division of Experimental Medicine


Contact information:

Telephone: (514) 412-4400, ext. 22342
e-mail address: janusz.rak@mcgill.ca
website: http://www.hopitalpourenfants.com/en/research/mch.aspx


Projects for Thesis Supervision:

1. Age-specific regulation of tumour angiogenesis.

2. The role of tumour microvesicles in angiogenesis and metastasis.

3. Anticancer effects of coagulation system inhibitors. The role of coagulation system in formation of the cancer stem cell niche.

Recent Publications:

Al-Nedawi, K., Meehan, B., Allison, A.C. and Rak, J. (2009)
Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR. Proc. Natl. Acad. Sci. 106: 3794-3799.

Milsom, C., Yu, J., Mackman, N., Micaleff, J., anderson, M., guha, A. and Rak, J. (2008)
Epidermal growth factor receptor-dependent upregulation of tissue factor is  modified by epithelial to mesenchymal transitions - Implications for tumor angiogenesis. Cancer Res. 68: 1168-1176.

Al-Nedawi, K., Meehan, B., Micallef, J., Lhotak, V., May, L., Guha, A. and Rak J. (2008)
Intercellular transfer of the oncogenic EGFRvIII via tumor cell derived microvesicles. Nature Cell Biology 5: 619-624.