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Contact
information:
Telephone: (514) 747-2451
e-mail address:
prem.ponka@mcgill.ca
website: http://www.medicine.mcgill.ca/physio/staffpages/pponka.htm
Projects for Thesis
Supervision:
1. Iron metabolism and heme synthesis in
developing red blood cells.
2. Hemoglobin iron recycling in macrophages.
3. Development of iron chelators to inhibit
tumor cell growth and prevent oxidative stress.
Recent
Publications:
Soe-Lin, S., Apte, S.S.,
Andriopoulos, B. Jr., Andrews, M.C., Segranzhofer, M., Kahawita, T.,
Garcia-Santos, D. and Ponka, P.
(2009)
Nramp1 promostes efficient macrophage recycling of iron following
erythrophagocytosis in vivo. PNAS 106: 5960-5965.
Zhang, A.-S., Canonne-Hergaux, F., Gruenheid,
S., Gros, P. and Ponka P.
(2008)
The use of Nramp-2-transfected Chinese hamster ovary cells and
reticulocytes from mk/mk mice to study iron transport mechanisms. Exp.
Hematol. 36: 1227-1235.
Szuber, N., Buss, J.L., Soe-Lin, S., Felfy, H.,
Trudel, M. and Ponka, P.
(2008)
Alternative treatment paradigm for thalassemia using iron chelators.
Exp. Hematol. 36: 773-785.
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