Professor – University of Montreal

Associate Member – Department of Medicine, Division of Experimental Medicine

Contact information:

Telephone: (514) 987-5571
e-mail address: zaher.hanna@ircm.qc.ca
website: http://www.ircm.qc.ca/fr/recherche/statique/unite4.html

Projects for Thesis Supervision:

1. Exploring the role of HIV-1 Nef expression in macrophages in inducing AIDS-like disease in transgenic mice.

2. Exploring cell signaling pathways in the cell subsets expressing HIV-1 Nef (CD4⁺ T cells, macrophages and dendritic cells) in transgenic mice.

Recent Publications:

Patrick Vincent, Elena Priceputu, Denis Kay, Kalle Saksela, Paul Jolicoeur and Zaher Hanna
Activation of pak2 and its association with Nef are conserved in murine cells, but are not sufficient to induce an aids-like disease in CD4C/HIV transgenic mice 2005, in press.

Hanna Z, Priceputu E, Hu C, Vincent P, Jolicoeur P.
HIV-1 Nef mutations abrogating downregulation of CD4 affect other Nef functions and show reduced pathogenicity in transgenic mice. Virology. 2005, in press

Elena Priceputu, Isabelle Rodrigue, Pavel Chrobak, Johanne Poudrier, Tak W. Mak, Zaher Hanna, Chunyan Hu, Denis G. Kay, and Paul Jolicoeur
The Nef-mediated AIDS-like disease of CD4C/human immunodeficiency virus transgenic mice is associated with increased Fas/FasL expression on T cells and T-cell death but is not prevented in Fas-, FasL-, tumor necrosis factor receptor 1-, or interleukin-1beta-converting enzyme-deficient or Bcl2-expressing transgenic mice. J Virol. 2005 May;79(10):6377-91.