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Contact
information:
Telephone: (514) 340-8222, ext.
5284
e-mail address: anne.gatignol@mcgill.ca
website:
http://www.mcgill.ca/microimm/department/associate_adjunct_prof/gatignol/
Projects for Thesis
Supervision:
1. Targeting cellular factors involved in HIV
expression to decrease viral replication.
2. Exploration of innate cellular response
mediated by RNA interference during HIV replication.
3. HIV-host cell molecular interactions in the
regulation of viral translation in lymphocytes and in astrocytes.
4. Function of TRBP-Dicer interaction in RNA
interference.
Recent Publications:
Bannwarth S, Laine S, Daher A, Grandvaux N,
Clerzius G, LeBlanc AC, Hiscott J,
Gatignol A.
Cell specific regulation of TRBP1 promoter by NF-Y transcription factor
in lymphocytes and astrocytes. J Mol Biol. 355: 898-910, 2006.
Gatignol A,
Laine S, Clerzius G.
Dual role of TRBP in HIV replication and RNA interference: viral
diversion of a cellular pathway or evasion from antiviral immunity?
Retrovirology. 2: 65, 2005.
Haase AD, Jaskiewicz L, Zhang H, Laine S, Sack
R, Gatignol A, Filipowicz
W.
TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts
with Dicer and functions in RNA silencing. EMBO Rep. 6: 961-967, 2005.
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