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Contact
information:
Telephone: (514) 398-8649
e-mail address:
thomas.duchaine@mcgill.ca
website: http://www.mcgill.ca/biochemistry/department/faculty/duchaine/
Projects for Thesis
Supervision:
1. RNAi-mediated genetic
regulation loops (endoRNAi in gene regulation).
2. Mechanisms of genetic
regulation by microRNAs.
Recent
Publications:
Mathonnet G, Fabian MR, Svitkin
YV, Parsyan A, Huck L, Murata T, Biffo S, Merrick WC, Darzynkiewicz E,
Pillai RS, Filipowicz W, Duchaine TF
and Sonenberg N.
Micro RNA inhibition of translation initiation in vitro by targeting the
cap-binding complex eIF4F. Science 317: 1764, 2007.
Duchaine T,
Wohlschlegel JA, Kennedy SG, Bei Y, Conte D Jr, Pang K-M, Brownell DR,
Harding S, Mitani S, Ruvkun G, Yates JR III and Mello CC.
Functional proteomics reveals the biochemical niche of C. elegans DCR-1
in multiple small-RNA mediated pathways. Cell 124: 343-354, 2006.
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