Division of Experimental Medicine

1. Mechanisms of immune glomerular cell injury and proteinuria. Role of phospholipases and protein kinases.

2. Role of SLK (a Ste-20-like kinase) in renal ischemia-reperfusion injury. Mechanisms/regulation of kinase activation, signaling effectors, functional effects, including apoptotic pathways.

3. Regulation of protein kinase signaling by extracellular matrix in the glomerulus. Activation of protein kinases, mediators of apoptosis/cell survival.

Ren, G., Takano, T., Papillon, J. and Cybulsky, A.V. (2010)
Cytosolic phospholipase A2-a enhancesinduction of endoplasmic reticulum stress. Biochim. Biophys. Acta Mol. Cell Res., In Press.

Cybulsky, A.V., Takano, T., Papillon, J., Bijian, K., Guillemette, J. and Kennedy, C.R.J. (2009)
Glomerular epithelial cell injury associated with mutant a-actinin-4. Am. J. Physiol. 297: F987-F995.

Cybulsky, A.V., Takano, T., Guillemette, J., Papillon, J., Volponi, R.A. and Di Battista, J.A. (2009)
The Ste20-like kinase, SLK, promotes p53 transactivation and apoptosis. Am. J. Physiol. 297: F971-F980.