Anna Mourskaia


Investigation of Mediators of Breast Cancer Skeletal Metastasis


I obtained my B.Sc. degree with a Major in Biology at McGill University. I then joined the Siegel lab in the fall of 2005 as a graduate student. My research interest lies in studying molecular mediators of breast cancer bone metastasis. I first focused on the role of bone microenvironment derived and tumor endogenous TGF-β in formation of breast cancer skeletal metastasis using animal models. I then aimed to identify tumor intrinsic factors responsible for breast cancer growth in bone in patient samples. In this search I identified and validated in animal models a member of human ATP-binding cassette (ABC) transporter family, ABCC5, to promote breast cancer skeletal metastasis. Finally I got involved in generation of a diagnostic gene expression predictor that distinguishes breast tumors that will relapse to bone.



Rosalind and Morris Goodman Cancer Research Centre - McGill University
1160 Pine Ave. West (Room 508)
Montreal, Quebec (Canada)
H3A 1A3
T. 514.398.8889
F. 514.398.6769