Peer Reviewed Publications.


Belle, J.I., Petrov, J.C., Langlais, D., Robert, F., Cencic, R., Shen, S., Pelletier, J., Gros, P., and Nijnik, A. (2016) Repression of p53-target gene Bbc3/PUMA by MYSM1 is essential for the survival of hematopoietic multipotent progenitors and contributes to stem cell maintenance. Cell Death & Differentiation 23: 759-775.

 Lee, T., Paquet, M., Larsson, O., and Pelletier, J. (2016) Tumor Cell Survival Dependence on the DHX9 DExH-Box Helicase. Oncogene PMID 26973242.

ohne, F., Langer, D., Martiné, U., Eider, C.S., Cencic, R., Begemann, M., Elbracht, M.,  Bülow, L., Eggermann, T., Zechner, U., Pelletier, J., Zabel, B.U., Enklaar T., and Prawitt, D., (2016) Kaiso mediates human ICR1 methylation maintenance and H19 transcriptional fine regulation. Clinical Epigenetics. In Press.

 Gandin, V., Masvidal, L., Hulea, L., Gravel,S.-P., Cargnello, M., McLaughlan, S., Cai, Y.,  Balanathan, P., Morita, M., Rajakumar, A., Furic, L., Pollak, M., Porco, Jr., J.A., St-Pierre, J., Pelletier, J., Larsson, O., and Topisirovic, I. (2016) nanoCAGE reveals 5’ UTR features that define specific modes of translation of functionally related mTOR-sensitive mRNAs. Genome Res. PMID: 26984228.

Chu, J., Galicia-Vázquez, G., Cencic, R., Mills, J.R., Porco, Jr., J.A., and Pelletier, J. (2106).  CRISPR-mediated Drug-Target Validation Reveals Selective Pharmacological Inhibition of the RNA Helicase, eIF4A. Cell Reports. In Press, PMID 27239032

Henry, S., Reisenauer, M.R., Magedov, I.V., Kiss, R., Mathieu, V., Lefranc, F., Medellin, D.C.,  Dasari, R., Evidente, A., Yu, X., Pertsemlidis, A., Cencic, R., Pelletier, J., Cavazos, D.A., Brenner, A.J., Aksenov, A.V., Rogelj, S., Kornienko, A., and Frolova L.V. (2016) 5,10b-Ethanophenanthridine Amaryllidaceae Alkaloids Inspire the Discovery of Novel Bicyclic Ring Systems with Activity Against Drug Resistant Cancer Cells. Eur. J. Med. Chem., In Press.

Manteghi, S., Gingras, M.-C., Kharitidi, D., Galarneau, L., Yan, M., Marques, M., Cencic, R., Rob4ert, F., Paquet3, M., Witcher, M., Pelletier, J., and Pause, A. (2016) Haploinsufficiency of the ESCRT component HD-PTP predisposes to cancer. Cell Reports 15, 1893 -1900.

Chu, J., Cencic, R., Wang, W., Porco, Jr., J.A., and Pelletier, J. (2016) Translation Inhibition by Rocaglates is Independent of eIF4E Phosphorylation Status. Mol Cancer Ther. 15:136-141.

Lee, T. and Pelletier, J. (2106). The biology of DHX9 and its potential as a therapeutic target. Oncogtarget. PMID 27034008.

 Cencic, R. and Pelletier. J (2016). Pharmacological Targeting of Eukaryotic Initiation Factor 4A. Translation. In Press.

 Chu, J., Cargnello, M., Topisirovic, I., and Pelletier, J. (2016) Reprogramming of Protein Synthesis by Translation Initiation Factors in Neoplasia. Submitted.


Malina, A., Robert, F., Jerry Pelletier (2015) PAM multiplicity marks genomic target sites as inhibitory to CRISPR/Cas9 editing. Nature Comm 6: 10124.

Pelletier, J., Graff, J., Ruggero, D. and Sonenberg, N. (2015). Targeting the eIF4F translation initiation complex: A critical nexus for malignancy. Canc. Research. Nature Rev. 75:250-263.Bhat, M., Robichaud, N., Hulea, L., Sonenberg, N., Pelletier, J., and Topisirovic, I. (2015) Targeting the translation machinery in cancer. Drug Dis. 14: 261-278.

Marco, M., Deyou, T., Gruhonjic, A., Holleran, J., Duffy, S., Heydenreich, M., Firtzpatrick, P.A., Landberg, G., Koch, A., Derese, S., Pelletier, J., Avery, V., Erdélyi,  M, and Yenesew, A. (2016) Pterocarpans and isoflavones from the roots of Millettia micans and of Millettia dura. Advances in Drug Discovery and Development 1: 1- 8

Cencic, R., Sénéchal, P., and Pelletier, J. (2015) Establishment of a Primary Screening Assay for the DHX9 Helicase. Combinatorial Chemistry & High Throughput Screening. 18, 844-861.

Robert, F.,  Barbeau, M., Éthier, S. Dostie, J., and Pelletier, J. (2015) Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing. Genome Medicine.  7: 93.

Galicia-Vázquez, G., Chu, J., and Pelletier, J. (2015) eIF4AII is not Required for miRNA-mediated Gene Silencing. RNA.  PMID: 26286746.

Nguyen, M., Cencic, R., Ertel, F., Bernier, C., Pelletier, J., Roulston, A., Silvius, J.R., and Shore, G. (2015) Obatoclax is a direct and potent antagonist of membrane-restrcited Mcl-1 and is synthetic lethal with treatment that induces Bim. BMC Cancer 15: 568. 

González-Almela, E., Sanz, M.A., García-Moreno, M., Northcote, P., Pelletier, J., and Carrasco, L. Differential action of Pateamine A on translation of genomic and subgenomic mRNAs from Sindbis virus. (2015) Virology 484: 41-50.

Andrei, A.-Z., Hall, A., Smith, A.L., Bascunana, C., Malina, A., Connor, A., Altinel-Omeroglu, G., Huang, S., Pelletier, J., Huntsman, D., Gallinger, S., Omeroglu, A., Metrakos, P., and Zogopoulos, G. (2015) Increased in vitro and in vivo sensitivity of BRCA2-associated pancreatic cancer to the poly(ADP-ribose) polymerase-1/2 inhibitor BMN 673. Cancer Letters 364: 8-16

Blagih, J., Galicia-Vázquez, G., Dupuy, F., Yurchenko, E., van der Windt, G.J.W., Viollet, B., Pearce, E.L., Pelletier, J., Piccirillo, C.A., Krawczyk, C.M., and Jones, R.G. (2015) The  energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo. Immunity 42: 41-54

Methot, S.P., Litler, L., Trajtenberg, F., Robert, F., Pelletier, J., Buschiazzo, A., Magor, B., and Di Noia, J.M. (2015) A complex with eEF1A1 retains functional AID in the cytoplasm. J. Exp. Med. 212:581-596. 


Cencic, R., Miura, H., Malina, A., Robert, F., Schmeing, T.M., Dostie, J., and Pelletier, J. (2014) Protospacer Adjacent Motif (PAM)-Distal Sequences Engage CRISPR Cas9 DNA Target Cleavage PLoS ONE. 9:e109213.    

Fukao, A., Mishima, Y., Takizawa, N., Oka, S., Imataka, H., Sonenberg, N., Thoma, C., and Fujiwara, T. (2014) microRNAs trigger dissociation of eIF4AI and II from target mRNAs in humans. Mol Cell. 56: 79-89.    

Robert, F., Roman, W., Bramoullé, A., Fellmann, C., Roulston, A., Shustik, C., Porco, J.A.Jr., Shore, G.C., Sebag, M., Pelletier, J. (2014). Translation Initiation Factor eIF4F Modifies the Dexamethasone Response in Multiple Myeloma. Proc. Natl. Acad. USA 111: 13421-13426.    

Lee, T., Di Paola, D., Malina, A., Mills, J., Kreps, A., Grosse, F., Tang, H., Zannis-Hadjopoulos, M., Larsson, O., and Pelletier, J. (2014) Suppression of the DHX9 helicase induces premature senescence in human diploid fibroblasts in p53-dependent manner. J.B.C. 289: 22798-22814.

 Sun, Y., Atas, E., Lindqvist, L.M., Sonenberg, N., Pelletier, J., and Meller, A. (2014). Single-molecule kinetics of the eukaryotic initiation factor 4AI upon RNA unwinding. Structure 22: 941-948.

Wolfe, A.L. Singh, K., Zhong, Y., Drewe, P., Rajasekhar, V.K., Sanghvi, V.R., Mavrakis, K.J., Roderick, J.E., Van der Meulen, J., Schatz, J.H., Rodrigo, C.M., Jiang, Zhao, C., Rondou, P., de Stanchina, E., Teruya-Feldstein, J., Kelliher, M.A., Speleman, F., Porco Jr., J.A., Pelletier, J., Rätsch, G., and Wendel H.-G. (2014) RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer. Nature. 513: 65-70

 Dow, L.E., Nasr, Z., Saborowski, M., Ebbesen, S.H., Manchado, E., Tasdemir, N., Pelletier, J., and Scott W Lowe (2014). Conditional reverse tet-transactivator mouse strains for the efficient induction of TRE-regulated genes in mice. PLoS One 9: 95236.

 Somaiah, R., Ravindar, K., Cencic, R., Pelletier J., and Pierre Deslongchamps (2014). Synthesis of the Antiproliferative Agent Hippuristanol and Its Analogues from Hydrocortisone via Hg(II)-Catalyzed Spiroketalization: Structure-Activity Relationship. J. Med. Chem. 57: 2511-2523

Martineau, Y., Azar, R., Muller, D., Lasfargues, C., El Khawand S , Anesia R , Pelletier, J., Bousquet, C., and Pyronnet, S. (2014). Pancreatic tumors escape from translation control through 4E-BP1 loss. Oncogene 33: 1367-1374.

Plank, T.-D. M., Whitehurst, J.T., Cencic, R., Pelletier, J., and Kieft, J.S. (2014). Internal translation initiation from HIV-1 transcripts is conferred by a common RNA structural element. Translation. Translation. 2: e27694

Shin, U., Williams, D.E., Kozakov, D., Hall, D.R., Beglov D., Vajda, V., Andersen, R.J., and Jerry Pelletier, J. (2014) Stimulators of Translation Identified During a Small Molecule Screening Campaign. Analytical Biochemistry 447: 6-14.

Galicia-Vázquez, G., Di Marco, S., Lian, X.J., Gallouzi, I.E., and Pelletier, J. (2014) Regulation of eukaryotic initiation factor 4AII by MyoD during murine myogenic cell differentiation. PLoS One. 9: e87237.


Nasr, Z., Dow, L.E., Paquet, M., Ravindar, K., Somaiah, R., Deslongchamps, P., Porco Jr., J.A., Lowe, S.W., and Pelletier, J. (2013) Suppression of Eukaryotic Initiation Factor 4E Prevents  Chemotherapy-Induced Alopecia.  BMC Pharmacology & Toxicology. 14:58. 

Boissonneault, K.R., Henningsen, B.M., Bates, S.S., Robertson, D.L., Milton,S., Pelletier, J., Hogan, D.A., Housman. D.E. (2013). Gene expression studies for the analysis of domoic acid production in the marine diatom Pseudo-nitzschia multiseries. BMC Molecular Biology. 14: 25.

Malina, A., Mills, J., Cencic, R., Yan, Y., Scchippers, L.M., Paquet, M., Dostie,J., Pelletier, J., (2013) Repurposing CRISPR/Cas9 for In Situ Functional Assays. Genes & Dev. 27: 2602-2614.

Cencic, R., Robert, F., Galicia-Vázquez, G., Malina, A., Ravindar, K., Somaiah, R., Pierre, P., Tanaka, J., Deslongchamps, P., and Pelletier, J. (2013) Modifying chemotherapy response by targeted inhibition of eukaryotic initiation factor 4A. Blood Cancer J. 3:e128.

Zhao, W.T., Zhou, C.F., Li, X.B., Fan, L., Zhang, Y., Pelletier, J., and Fang, J. (2013). The von Hippel-Lindau Protein pVHL Inhibits Ribosome Biogenesis and Protein Synthesis.  J.B.C.  288:16588-16597.

Martineau, Y., Muller, D., Azar, R., Lasfargues, C., Pelletier, J., Bousquet, C., and Pyronnet, S. (2013). Pancreatic tumors escape from translation control through 4E-BP1 loss. Oncogene 33:1367-1374.

 Navrátilová, A., Schneiderová, K., Veselá, D., Hanáková, Z., Fontana, A., Dall´Acqua, S., Cvačka, J., Innocenti, G., Novotná, J., Urbanová, M., Pelletier, J., Čížek, A., Žemličková, H., Šmejkal, K., (2013). Minor C-geranylated Flavanones from Paulownia tomentosa Fruits with MRSA Antibacterial Activity. Phytochemistry 89: 104-113.

Garcia-Moreno, M., Sanz, M.A., Pelletier J., and Carrasco, L. (2013). Requirements for eIF4A and eIF2 during translation of Sindbis virus subgenomic mRNA in vertebrate and invertebrate host cells . Cellular Microbiology. Cellular Microbiol. 15: 823-840.

Mills, J., Malina, A., Lee, T. Di Paola, D. Larsson, O. Miething, C. Grosse, F. Tang, H. Zannis-Hadjopoulos, M. Lowe, S. W., Pelletier, J. (2013). RNAi screening uncovers Dhx9 as a modifier of ABT-737 resistance in an E-myc/Bcl-2 mouse model. Blood121: 3402-3412.

Nasr, Z., Robert, F., Porco Jr., J.A., Muller, W.J., and Pelletier, J. (2013). eIF4F suppression in breast cancer affects maintenance and progression. Oncogene. 32: 861-871.


Galicia-Vázquez, G., Cencic, R., Robert, F., Agenor, A.Q., and Pelletier, J. (2012). A Cellular Response Linking eIF4AI Activity to eIF4AII Transcription. RNA 18: 1373-1384.

Di Marco, S., Cammas, A., Lian, X., Kovacs, E.N., Mazroui, R., Pelletier, J., and Eddine Gallouzi, I. (2012). The eIF4A inhibitor Pateamine A prevents the onset of cytokine-induced muscle wasting. Nature Communication 3: 896.

Scuoppo, C., Miething, C., Lindqvist, L., Reyes, J., Ruse, C., Appelmann, I., Yoon, S., Krasnitz, A., Teruya-Feldstein, J., Pappin, D., Pelletier J., & Lowe, S.W. (2012). A tumor suppressor network relying on the polyamine-hypusine axis. Nature 487: 244 – 248.

Sun, Y., Atas, E., Lindqvist, L., Sonenberg, N., Pelletier, J., and Meller, A. (2012). The eukaryotic initiation factor eIF4H facilitates loop-binding, repetitive RNA unwinding by the eIF4A DEAD-box helicase. Nucl Acids Res. 40: 6199-6207.

Lin, C.-J., Nasr, Z., Premsrirut, P.K., Porco, J.A. Jr., Hippo, Y., Lowe, S.W., and Pelletier, J. (2012). Targeting synthetic lethal interactions between Myc and the eIF4F complex impedes tumorigenesis. Cell Reports 1: 325-333.

Robert, F., Mills, J., Agenor, A., Wang, D., Di Marco, S., Cencic, R., Tremblay, M., Gallouzi, I.E., Hekimi, S., Wing, S.S., and Pelletier, J. (2012). Targeting protein synthesis in a Myc/mTOR-driven model of Anorexia-Cachexia Syndrome Delays Its Onset and Prolongs Survival. Cancer Res. 72: 747-756.

Mills, J.R., Malina, A., and Pelletier, J. (2012). Inhibiting Mitochondrial-Dependent Proteolysis of Mcl-1 Promotes Resistance to DNA Damage. Cell Cycle 11: 88-98.

Rodrigo, C.M., Cencic, R., Roche, S.P., Pelletier, J. and Porco Jr., J.A. (2012). Synthesis of Rocaglamide hydrozamates and related compounds as eukaryotic translation inhibitors: Synthetic and biological studies. J. Med. Chem. 55: 558-562.


Fred, R.G., Sandberg, M., Pelletier, J., and Welsh, N. (2011). The human insulin mRNA is partly translated via a cap-and eIF4A-independent mechanism. Biochem Biophys Res Commun. 12: 693-698.

Kozakov, D., Hall, D.R., Chuang, G.-Y., Cencic, R., Brenke, R., Beglov, D., Pelletier, J., Whitty, A., and Vadja, S. (2011) Structural conservation of druggable hot spots in protein–protein interfaces. PNAS 108: 13528-13533.

Schatz, J.H., Oricchio, E., Jiang, M., Linkov, I., Maragulia, J., Shi, W., Zhang, Z., Zelenetz, A., Teruya-Feldstein, J., Pelletier, J., and Wendel, H.-G. (2011) Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphomaJ. Exp. Med. 208: 1799-1807.

Wahba, A.S., Azizi, F., Deleavey, G.F., Brown, C., Robert, F., Carrier, M., Kalota, A., Gewirtz, A.M., Pelletier, J., Hudson, R.H.E., and Damha, M.J. (2011). Phenylpyrrolocytosine as an unobtrusive base modification for monitoring activity and cellular trafficking of siRNA.  ACS Chem. Biol. 6: 912-919.

Konicek, B.W., Stephens, J.R., McNulty, A.M., Robichaud, N., Peery, R.B., Dumstorf, C.A., Dowless, M.S., Iversen, P.W., Parsons, S., Ellis, K.E., McCann, D.J., Pelletier, J., Furic, L., Yingling, J.M., Stancato, J.F., Sonenberg, N., and Graff, J.R. (2011). Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung metastasis. Cancer Res. 71: 1849-1857.

Dauber B, Pelletier J, Smiley JR. (2011). The Herpes Simplex Virus 1 vhs protein enhances translation of viral true late mRNAs and virus production in a cell type-dependent manner. J. Virol. 85: 5363-5373.

Cencic R, Desforges M, Hall DR, Kozakov D, Du Y, Min J, Dingledine R, Fu H, Vajda S, Talbot PJ, Pelletier J. (2011) Blocking eIF4E:eIF4G interaction as a strategy to impair coronavirus replication. J. Virol.  85: 6381-6389.

 Warr, M.R., Mills, J.R., Nguyen, M., Lemaire-Ewing, S., Baardnsnes, J., Sun, K.L.W., Malina, A., Young, J.C., Jeyaraju, D.V., O’Connor-McCourt, M., Pellegrini, L., Pelletier, J., and Shore, G. (2011). Mitochondrial-dependent N-terminal Processing of Outer Membrane Mcl-1 Removes an Essential Mule/Lasu1 Binding Site. J. Biol. Chem. 286: 25098-25107.


 Huang, S-X., Zhao, L-X., Jiang, C-J., Duan, Y., Roberts, F., Pelletier, J., and Shen, B. (2010) Cycloheximide and congeners, inhibitors of eukaryotic protein synthesis, from Streptomyces sps. YIM56141 and 56132. J. Antibiotics. 64: 163-166.

Takacs, J.E., Neary, T.B., Ingolia, N.T., Martin-Marcos, P., Weissman, J.S., Pelletier, J., Hinnebusch, A.G., and Lorsch, J.R (2010). Identification of compounds that decrease the fidelity of start codon recognition by the eukaryotic translational machinery. RNA. 17: 439-452.

Cencic, R., Hall, D.R., Robert, F., Du, Y., Min, J., Li, L., Qui, M., Lewis, I., Kurtkaya, S., Dingledine, R., Fu, H., Kozakov, D., Vadja, S., and Pelletier, J. (2011). Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F. PNAS 108: 1046-1051

Ravindar, K., Reddy, M.S., Lindqvist, L., Pelletier, J., and Deslongchamps, P. (2011). Synthesis of the antiproliferative agent hippuristanol and its analogues via Suárez cyclizations and Hg(II)-catalyzed spiroketalizations. J. Org. Chem. 76: 1269-1284.

Lindqvist, L., Robert, F., Merrick, W., Kakaeya, H., Fraser, C., Osada, H., and Pelletier, J. (2010). Inhibition of translation by cytotrienin A – a member of the ansamycin family. RNA, 16: 2404-2413.

Ravindar, K., Reddy, M.S., Lindqvist, L., Pelletier, J., and Deslongchamps, P. (2010). An efficient synthetic approach to potent antiproliferative agent hippuristanol via Hg(II) catalyzed spiroketalization. Org. Lett. 12: 4420–4423.

Belanger, F., Steinski, J., Darznkiewicz, E., and Pelletier, J. (2010). Characterization of hMTr1, a human cap1 2’-O-ribose methyltransferase. J. Biol. Chem. 285: 33037-33044.

Malo, N., Hanley, J., Carlile, G., Liu, J., Pelletier, J., Thomas, D., Nadon, R. (2010). Experimental design and statistical methods for improved hit detection in high-throughput screening. Journal of Biomolecular Screening15: 990-1000.

Roche, S.P., Cencic, R., Pelletier, J., and Porco, Jr, J.A. (2010) Biomimetic photocycloaddition of 3-Hydroxyflavones: Synthesis and evaluation of rocaglate derivatives as inhibitors of eukaryotic translation. Angewandte Chemie Int. Ed. 49: 6533–6538.

Roche, S.P., Cencic, R., Pelletier, J., and Porco, Jr, J.A. (2010) Biomimetic photocycloaddition of 3-Hydroxyflavones: Synthesis and evaluation of rocaglate derivatives as inhibitors of eukaryotic translation. Angewandte Chemie Int. Ed., 49: 6533–6538.

Van Goietsenoven, G., Hutton, J., Becker, J.-P., Lallemand, B., Robert, F., Lefranc, F., Pirker, C., Vandenbussche, G., Van Antwerpen, P., Evidente, A., Berger, W., Prévost, M., Pelletier, J., Kiss, R., Goss Kinzy, T., Kornienko, A., and Mathieu, V. (2010). eEF1A Is a Target for Amaryllidaceae Isocarbostyrils to Combat Melanomas. FASEB J. 24: 4575-4584.

Lin, C-J., Robert, F., Sukarieh, R., Michnick, S., and Pelletier, J. (2010). The antidepressant sertraline inhibits translation initiation by curtailing mTOR signaling. Cancer Res. 70: 3199-3208.

Deleavey, G.F., Watts, J.K., Alain, T., Robert, F., Kalota, A., Aishwarya, V., Pelletier, J., Gewirtz, A.M., Sonenberg, N., and Damha, M.J. (2010). Synergistic effects between analogs of DNA and RNA improve the potency of siRNA-mediated gene silencing. Nucl. Acids Res. 38: 4547-4557.

Sukarieh, R., Sonenberg, N., and Pelletier, J. (2010). Nuclear assortment of eIF4E coincides with shut-off of host protein synthesis upon poliovirus infectionJ. Gen Virol. 91: 1224-1228.

Lomenick, B., Hao, R., Jonai, N., Chin, R.M., Aghajan, M., Warburton, S., Wang, J., Wu, R.P., Gomez, F., Loo, J.A., Wohlschlegel, J.A., Vondriska, T.M., Pelletier, J., Herschman, H.R., Clardy, J., Clarke, C.F., Huang, J. (2009) Target Identification using drug affinity responsive target stability (DARTS). Proc. Natl. Acad. Sci USA. 106: 21984-21989.

 Cencic, R., Carrier, M., Trnkus, A., Porco Jr, J.A., Minden, M., and Pelletier, J. (2010) Synergistic effect of inhibiting translation initiation in combination with cytotoxic agents in acute myelogenous leukemia cells. Leukemia Res. 34: 535-541.


Dehbi M, Moeck G, Arhin FF, Bauda P, Bergeron D, Kwan T, Liu J, McCarty J, Dubow M, Pelletier J. (2009) Inhibition of transcription in Staphylococcus aureus by a primary sigma factor-binding prolypeptide from phage G1. J. Bacteriol. 191: 1761-1771.

Mokas, S., Mills, J.R., Garreau, C., Fournier, B., Robert, F., Arya, P., Kaufman, R.J., Pelletier, J., and Mazroui, R. (2009) Uncoupling Stress Granule assembly and translation initiation inhibition. Mol. Biol. Cell20: 2673-2683.

 Robert, F., Carrier, M., Rawe, S., Chen, S., Lowe, S., and Pelletier, J. (2009) Altering chemosensitivity by modulating translation elongation. PloS One 4: e5428.

Robert, F., Williams, C., Yan, Y., Donohue, E.,  Cencic, R., Burley, S.K., and Pelletier, J. (2009) Blocking UV-induced eIF2a phosphorylation with small molecule inhibitors of GCN2. Chem Biol. Drug Des. 74: 57-67.

Livingstone, M., Larsson, O., Sukarieh, R., Pelletier, J., and Sonenberg, N. (2009) A chemical genetic screen for mTOR pathway inhibitors based on 4E-BP-dependent nuclear accumulation of eIF4E. Chem Biol. 16: 1240-1249.

Cencic, R., Carrier, M., Galicia Vazquez, G., Bordeleau, M.-E., Sukarieh, R., Bourdeau, A., Brem, B., Teodoro, J.G., Greger, H., Tremblay, M., Porco, J., and Pelletier, J. (2009) Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol. PloS One 4: e5223.

 Lin, C.-J., Sukarieh, R., and Pelletier, J. (2009) Silibinin inhibits translation initiation: Implications for anticancer therapy. Mol. Cancer Ther. 8: 1606-1612.

Sukarieh, R., Sonenberg, N., and Pelletier, J. (2009) The eIF4E binding proteins (4E-BPs) are modifiers of cytoplasmic eIF4E relocalization during the heat shock response. Am. J. Physiol Cell Physiol296: C1207-1217.

Beutler, J.A., Kang, M.-I., Robert, F., Clement, J.A., Pelletier, J., Colburn, N.H., McKee, T.C., Goncharova, E., McMahon, J.B., and Henrich, C.J. (2009). Quassinoid inhibition of AP-1 function does not correlate with cytotoxicity or protein synthesis inhibition.  J. Natl. Prod. 72: 503-506.

Ran, I., Laplante, I., Bourgeois, C., Pépin, J., Lacaille, P., Costa-Mattioli, M., Pelletier, J., Sonenberg, N., and Lacaille, J.-C., (2009) Persistent transcription- and translation-dependent long-term potentiation induced by mGluR1 in hippocampal interneurons.  J. Neurosci. 29: 5605-5615.

Vázquez, G.C., Lindqvist, L., Harvey, I., and Pelletier, J. (2009). High-throughput assays probing Protein:RNA interactions of eukaryotic translation  initiation factors. Anal. Bioch. 384: 180-188.

Gravel, M., Robert, F., Kottis, V., Gallouzi, I.-E., Pelletier, J., and Braun, P. (2009) 2’3’-cyclic nucleotide 3’-phosphodiesterase – A novel RNA-binding protein that inhibits protein synthesis. J. Neurosci. Res87: 1069-1079.

Mavrakis, K.J., Zhu, H., Silva, R.L., Mills, J.R., Teruya-Feldstein, J., Lowe, S., Tam, W., Pelletier, J., and Wendel, H.G. (2008). Tumorigenic activity and therapeutic inhibition of Rheb GTPase. Genes & Dev. 22: 2178-2188.

Bordeleau, M.E., Robert, F., Gerard, B., Lindqvist, l., Wendel, H.-G., Brem, B., Greger, H., Lowe, S.W., Porco Jr, J.A., and Pelletier, J. (2008) Therapeutic suppression of translation initiation reverses chemoresistance. J. Clin. Inv., 118: 2651-2660.

Lin, C.-J., Cencic, R., Mills, J., Robert, F., and Pelletier, J. (2008). c-Myc and eIF4E are components of a Feedforward Loop that Link Transcription and Translation. Cancer Res., 68: 5326-5334

Mills, J.R., Hippo, Y., Robert, F., Chen, S.M.H., Malina, A., Lin, C.-J., Trojahn, U., Wendel, H.-G., Charest, A., Bronson, R.T., Kogan, S.C., Nadon, R., Housman, D., Lowe, S.W., and  Pelletier, J. (2008). mTORC1 promotes survival through translational control of Mcl-1. PNAS 105: 10853-10858.

Rong, L., Livingstone, M., Sukarieh, R., Petroulakis, E., Gingras, A.-C. G., Crosby, K., Smith, B., Polakiewicz, R.D., Pelletier, J., Ferraiuolo, M.A., and Sonenberg, N. (2008). Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs. RNA 14: 1318-1327.

Lindqvist, L., Oberer, M., Reibarkh, M., Cencic, R., Bordeleau, M.-E., Vogt, E., Marintchev, A., Tanaka, J., Fagotto, F., Altmann, M., Wagner, G., and Pelletier, J. (2008). Selective Pharmacological Targeting of a DEAD box RNA helicase. PLOS ONE. 3: e1583.

Lindqvist, L., Imataka, H., and Pelletier, J. (2008). Cap-dependent eukaryotic initiation factor-mRNA interactions probed by cross-linking. RNA 14: 960-969.

Wendel, H.G., Silva, R.L., Malina, A., Mills, J.R., Zhu, H., Ueda, T., Watanabe-Kukunaga, R., Fukunaga, R., Teruya-Feldstein, J., Pelletier, J., and Lowe, S. (2007) Dissecting eIF4E action in tumorigenesis. Genes Dev. 21: 3232-3237.

Gerard, B., Cencic, R., Pelletier, J., and Porco, J.A., Jr. (2007). Enantioselective synthesis of the complex rocaglate (-)-silvestrol. Angew. Chem. Int. Ed. Engl. 46: 7831-7834.

Kazemi, S., Mounir, Z., Baltzis, D., Raven, J.F., Wang, S., Krishnamoorthy, J.L.,  Pluquet, O., Pelletier, J., and Koromilas, A.E. (2007). A novel function of eIF2alpha kinases as inducers of the phosphoinositide-3-kinase signaling pathway. Mol. Biol. Cell. 18: 3635-3644.

Costa-Mattioli, M., Gobert, D., Stern, E., Gamache, K., Colina, R., Cuello, C., Sossin, W., Kaufman, R., Pelletier, J., Rosenblum, K., Krnjevic, K., Lacaille, J.-C. Nader, K., and Sonenberg, N. (2007) eIF2 phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory. Cell 129: 195-206.

Cencic. R., Yan, Y., and Pelletier, J. (2007). Homogenous time resolved fluorescence assay to identify modulators of cap-dependent translation initiation. Combinatorial Chemistry & High Throughput Screening. 10: 181-188.

Akimitsu, N., Tanaka, J., and Pelletier, J. (2007). Translation of nonSTOP mRNA is repressed post-initiation in mammalian cells. EMBO J26: 2327-2338.

Watts, JK, Choubdar N, Sadalapure K, Robert F, Wahba AS, Pelletier J, Mario Pinto B, Damha MJ. (2007) 2'-Fluoro-4'-thioarabino-modified oligonucleotides: conformational switches linked to siRNA activity. Nucleic Acids Res.  35: 1441-1451.

Bordeleau, ME, Cencic, R, Linqvist, L, Oberer, M, Northcote, P, Wagner, G, Pelletier, J. (2006) RNA-mediated sequestration of the RNA helicase eIF4A by Pateamine A inhibits translation initiation. Chem Biol. 13: 1287-1295.

Speval, CC, Park, EH, Geballe, AP, Pelletier, J, Sachs, MS. (2006). her-2 upstream open reading frame effects on the use of downstream initiation codons. Biochem Biophys Res Commun. 350: 834-841.

Belley, A., Callejo, M., Arhin, F., Dehbi, M., Fadhil, I., Liu, J., McKay, G., Srikumar, R., Bauda, P., Bergeron, D., Ha, N., DuBow, M., Gros, P., Pelletier, J., and Moeck, G. (2006) Competition of bacteriophage polypeptides with native replicase proteins for binding to the DNA sliding clamp reveals a novel mechanism for DNA replication arrest in Staphylococcus aureus. Mol. Microbiol. 62: 1132-1143.

Robert, F., Kapp, L.D., Khan, S.N., Acker, M.G., Kolitz, S., Kazemi, S., Kaufman, R.J., Merrick, W.C., Koromilas, A.E., Lorsch, J.R., and Pelletier, J. (2006). Initiation of protein synthesis by Hepatitis C virus is refractory to reduced eIF2•GTP•Met-tRNAiMet ternary complex availability. Mol. Biol. Cell17: 4632-4644.

Wendel, H.-G., Malina, A., Zhao, Z., Zender, L., Kogan, S.C., Cordon-Cardo, C., Pelletier, J., and Lowe, S.W. (2006). Determinants of sensitivity and resistance to rapamycin-chemotherapy drug combinations  in vivoCancer Res. 66: 7639-7646.

Mazroui, R., Sukarieh, R., Bordeleau, M.E., Kaufman, R.J., Northcote, P., Tanaka, J., Gallouzi, and Pelletier, J. (2006). Inhibition of ribosome recruitment induces stress granule formation independent of eIF2 phosphorylation.  Mol. Biol. Cell. 17: 4212-4219.

Chaudhry, Y., Nayak, A., Bordeleau, M.E., Tanaka, J., Pelletier, J., Belsham, G.J., Roberts, L.O., and Goodfellow, I.G. (2006). Caliciviruses differ in their functional requirements for eIF4F components. J. Biol. Chem. 281, 25315-25325.

Arhin, F., Belanger, O., Ciblat, S., Dehbi, M., Delorme, D., Dietrich, E., Dixit, D., Lafontaine, Y., Lehoux, D., Liu, J., McKay, G.A., Moeck, G., Reddy, R., Rose, Y., Srikumar, R., Tanaka, K.S.E., Williams, D.M., Gros, P., Pelletier, J., Parr, T.R., and Far, A.R. (2006) A new class of small molecule RNA polymerase inhibitors with activity against Rifampicin-resistant Staphylococcus aureusBioorg. & Med. Chem. Lett. 14: 5812-5832.

McKay, G.A., Reddy, R., Arhin, F., Belley, A., Lehoux, D., Moeck, G., Sarmiento, I., Parr, T.R., Gros, P., Pelletier, J., and Far, A.R. (2006) Triaminotriazine DNA helicase inhibitors with antibacterial activity. Bioorg. & Med. Chem. Lett. 16: 1286-1290.

Malo, N., Hanley, J.A., Cerquozzi, S., Pelletier, J., and Nadon, R. (2006). Statistical practice in high-throughput screening data analysis. Nat. Biotech24: 167-175.

Robert, F., Gao, H.Q., Donia, M., Merrick, W.C., Hamann, M.T., and Pelletier, J. (2006). Chlorolissoclimides: New inhibitors of eukaryotic protein synthesis. RNA 12: 717-724.

Chard, L.S., Bordeleau, M.E., Pelletier, J., Tanaka, J., and Belsham, G.J. (2006) Hepatitis C virus-related internal ribosome entry sites are found in multiple genera of the family Picornaviridae. J. Gen. Virol. 87: 927-936.

Bordeleau, M.-E., Mori, A., Oberer, M., Lindqvist, L., Higa, T., Belsham, G., Wagner, G., Tanaka, J., and Pelletier, J. (2006). Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A. Nat. Chem. Biol. 2: 213-220.

Petersen, C.P., Bordeleau, M.-E., Pelletier, J., and Sharp, P. (2006). Short RNAs repress translation after initiation in mammalian cells. Mol. Cell. 21: 533-542.

Park, E.-H., Lee, J.M., and Pelletier, J. (2006). The Tie2  5’ Untranslated Region is Inhibitory to  5’ end-Mediated Translation Initiation. FEBS Letters580: 1309-1319.

Kwan, T., Liu, J., DuBow, M., Gros, P. and Pelletier, J. (2006). Comparative Genomic Analysis of 18 Pseudomonas aeruginosa Bacteriophages. J. Bact. 188: 1184-1187

Yan, Y., Svitkin, Y., Lee, J.M., Bisaillon, M., and Pelletier, J. (2005). Ribavirin is not a functional mimic of the 7-methyl guanosine mRNA cap. RNA 11; 1238-1244.

Bordeleau, M.-E., Matthews, J., Wojnar, J.M., Lindqvist, L., Novac, O., Jankowsky, E., Sonenberg, N., Northcote, P., Teesdale-Spittle, P., and Pelletier, J. (2005) Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation. Proc. Natl. Acad. Sci. USA 102: 10460-10465.

Park, E., Lee, J.M., Blais, J.D., Bell, J.C., and Pelletier, J. (2005). Internal translation initiation mediated by the angiogenic factor Tie2. J. Biol. Chem. 280:   20945-20953.

Hamdan, F.F., Audet, M., Garneau, P., Pelletier, J., and Bouvier, M. (2005). High-throughput screening of G protein-coupled receptors antagonists using a BRET1-based -arrestin2 recruitment assay. J. Biomolecular Screening. 10: 463-475.

Kwan, T., Liu, J., Dubow, M., Gros, P., Pelletier, J. (2005) The complete genomes and proteomes of 27 Staphylococcus aureus bacteriophages. Proc. Natl. Acad. Sci USA 102: 5174-5179.

Prawitt, D., Enklaar, T., Gartner-Rupprecht, B., Spangenberg, C., Fees, S., Lucito, R., Reutzel, D., Brozek, I., Limon, J., Pelletier, J., and Zabel, B. (2005). Microdeletion of target sites for insulator protein CTCF in a chromosome 11p15 imprinting center in Beckwith-Wiedemann syndrome and Wilms' tumor. Proc. Natl. Acad. Sci USA 102: 4085-4090.

Malina, A., Khan, S., Carlson, C.B., Svitkin, Y., Harvey, I., Sonenberg, N., Beal, P., and Pelletier, J. (2005). Inhibitory properties of nucleic acid-binding ligands on protein synthesis. FEBS Lett. 579: 79-89.

Fukamiya, N., Lee, K.-H., Muhammad, I., Murakami, C., Okano, M., Harvey, I., and Pelletier, J. (2005). Structure-activity relationships of quassinoids for eukaryotic protein synthesis. Canc. Lett. 220: 37-48.

Kumar, R., Garneau, P., Nguyen, N., Lown, J.W., and Pelletier, J. (2004). Methionine substituted polyamides are RNAse mimics that inhibit translation. J. Drug. Target. 12: 125-134.

Muhammad, I., Bedir, E., Khan, S.I., Tekwani, B.L. Khan, I.A., Takamatsu, S., Pelletier, J., and Walker, L.A. (2004). A new antimalaria quassinoid from Simaba orinocensisJ. Nat. Prod. 67: 772-777.

Wendel, H.-G., de Stanchina, E., Fridman, J., Malina, A., Ray, S., Kogan, S., Cordon-Cardo, C., Pelletier, J., and Lowe, S. (2004). Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy. Nature 428: 332-337.

Lee, H.J., Kim, S., Pelletier, J., and Kim, J. (2004). Stimulation of hTAFII68 (NTD)-mediated transactivation by v-src. FEBS Letters 564: 188-198.

Itoh, A., Tanahashi, T., Nagakura, N., Takenaka, Y., Chen, C.-C., and Pelletier, J. (2004) Flavonoid glycosides from Adina racemosa and their inhibitory activities on eukaryotic protein synthesis. J. Nat. Prod67: 427-431.

Novac, O., Guenier, A.-S., and Pelletier, J. (2004). Inhibitors of protein synthesis identified by a high throughput multiplexed translation screen. Nucl. Acids Res. 32: 902-915.

Chan, J., Khan, S.N., Harvey,  I., Merrick, W., and Pelletier, J. (2004) Novel Eukaryotic Protein Synthesis Inhibitors Identified by  Comparison of Cytotoxicity Profiles. RNA 10: 528-543.

Discenza, M.T., Vaz, D., Hassell, J., and Pelletier, J. (2004). Activation of the WT1 tumor suppressor gene promoter by Pea3. FEBS Letters 560: 183-191.

Wang. B., Pelletier, J., Massaad, M.J., Herscovics, A., and Shore, G.C. (2004). The yeast split-ubiquitin membrane protein two-hybrid screen identifies BAP31 as a regulator of the turnover of endoplasmic reticulum-associated protein tyrosine phosphatase-like B. Mol. Cell. Biol. 24: 2767-2778.

Liu, J., Dehbi, M., Moeck, G., Arhin, F., Bauda, P., Bergeron, D., Callejo, M., Ferretti, V., Ha, N., Kwan, T., McCarty, J., Srikumar, R., Williams, D., Wu, J., Gros, P., Pelletier, J., and DuBow, M. (2004) Antimicrobial drug discovery from bacteriophage genomics.  Nat. Biotech. 22: 185-191.

Discenza, M.T., He, S., Lee, T. H., Chu, L.L., Bolon, B., Goodyer, P., Eccles, M. and Pelletier, J. (2003). WT1 is a Modifer of the Pax2 Mutant Phenotype: Cooperation and Interaction Between WT1 and Pax2. Oncogene 22: 8145-8155.

Lee, J., Park, E.H., and Pelletier, J. (2002) An Upstream Open Reading Frame Impedes Translation of the Huntingtin Gene. Nucl. Acids Res. 30: 5110-5119.

Lee, T., Lwu, S., Kim, J.,  and Pelletier, J. (2002). Inhibition of Wilms Tumor 1 Transactivation by Bone Marrow Zinc Finger 2, a Novel Transcriptional Repressor.  J. Biol. Chem. 277: 44826-44837.

Carriere, M., Applefield, D., Harvey, I., Garneau, P., Lorsch, J., Lapidot, A., and Pelletier, J. (2002) Inhibition of protein synthesis by aminoglycoside-arginine conjugates. RNA 8: 1267-1279.

Harvey, I., Garneau, P., Pelletier, J. (2002). Inhibition of translation by RNA-small molecule interactions. RNA8: 452-463. 

Cai, J., Daoud, R., Alqawi, O., Georges, E., Pelletier, J., and Gros, P. (2002). Nucleotide binding and nucleotide hydrolysis properties of the ABC transporter MRP6(ABCC6). Biochemistry 41: 8058-8067.

Harvey, I., Garneau, P., Pelletier, J. (2002). Forced engagement of a RNA/protein complex by a chemical inducer of dimerization to modulate gene expressionProc. Natl. Acad. Sci. USA 99: 1882-1887.

Schneider R, Agol VI, Andino R, Bayard F, Cavener DR, Chappell SA, Chen JJ, Darlix JL, Dasgupta A, Donze O, Duncan R, Elroy-Stein O, Farabaugh PJ, Filipowicz W, Gale M Jr, Gehrke L, Goldman E, Groner Y, Harford JB, Hatzglou M, He B, Hellen CU, Hentze MW, Hershey J, Hershey P, Hohn T, Holcik M, Hunter CP, Igarashi K, Jackson R, Jagus R, Jefferson LS, Joshi B, Kaempfer R, Katze M, Kaufman RJ, Kiledjian M, Kimball SR, Kimchi A, Kirkegaard K, Koromilas AE, Krug RM, Kruys V, Lamphear BJ, Lemon S, Lloyd RE, Maquat LE, Martinez-Salas E, Mathews MB, Mauro VP, Miyamoto S, Mohr I, Morris DR, Moss EG, Nakashima N, Palmenberg A, Parkin NT, Pe'ery T, Pelletier J, Peltz S, Pestova TV, Pilipenko EV, Prats AC, Racaniello V, Read GS, Rhoads RE, Richter JD, Rivera-Pomar R, Rouault T, Sachs A, Sarnow P, Scheper GC, Schiff L, Schoenberg DR, Semler BL, Siddiqui A, Skern T, Sonenberg N, Tahara SM, Thomas AA, Toulme JJ, Wilusz J, Wimmer E, Witherell G, Wormington M. (2001) New ways of initiating translation in eukaryotes. Mol. Cell. Biol. 21, 8238-8246.

Lee, T.H., and Pelletier, J. (2001). Functional characterization of WT1 binding sites within the human vitamin D receptor gene promoter. Physiol. Genomics7: 187-200.

Das, M., Burge, C., Park, E., Colinas, J., and Pelletier, J. (2001). Assessment of the total number of human transcription units. Genomics77: 71-78.

Das, M., Sakul, H., Kong, J., Acland, G., and Pelletier, J., (2000). A Set of Canine Inter-repeat Sequence PCR Markers for High Throughput Genotyping. Physiol. Genomics 4: 13-24.

Kim, J., Lee, J.M., Branton, P.E., and Pelletier, J. (2000). Modulation of EWS/WT1 activity by the v-Src protein tyrosine kinase. FEBS Lett474: 121-128.

Rodriguez, P., Pelletier, J., Price, G., and Zannis-Hadjopoulos, M. (2000). NAP-2: Histone chaperone function and phosphorylation state through the cell cycle. J. Mol. Biol. 298: 225-238.75. Moffett, P., and Pelletier, J. (2000). Differential transcriptional properties of mSim-1 and mSim-2. FEBS Letters 466: 80-86.

Prawitt, D., Enklaar, T., Klemm, G., Gaertner, B., Spangenberg, C., Winterpacht, A., Higgins, M., Pelletier, J., and Zabel, B. (2000) Identification and characterization of MTR1, a novel gene with homology to melastatin (MLSN1) and the trp gene family located in the BWS-WT2 critical region on chromosome 11p15.5 and showing allele-specific expression. Hum. Mol. Genet. 9: 203-216.


Kim, J., Lee, J.M., Branton, P.E., and Pelletier, J. (1999). Modification of EWS/WT1 functional properties by phosphorylation. Proc. Natl. Acad. Sci96: 14300-14305.

Lee, T.H., Moffett, P., and Pelletier, J. (1999) The Wilms tumor suppressor gene (wt1) product represses different functional classes of transcriptional activation domains. Nucl. Acids Res. 27: 2889-2897.

Kim, J., Prawitt, D., Bardeesy, N., Torban, E., Vicaner, C., Goodyer, P., Zabel, B.,  and Pelletier, J. (1999). The Wilms’ Tumor Suppressor Gene (wt1) Product Regulates Dax-1 Gene Expression During Gonadal Differentiation. Mol. Cell. Biol. 19: 2289-2299.

Reece, M., Prawitt, D., Landers, J., Kast, C., Gros, P., Housman, D., Zabel, B.U., and Pelletier, J. (1998) Functional characterization of ORCTL2 – an organic cation transporter expressed in the renal proximal tubules. FEBS Lett. 433: 245-250.

Diller, L., Ghahremani, M., Morgan, J., Grundy, P., Reeves, C., Breslow, N., Green, D., Neubergm D., Pelletier, J., and Li, F.P. (1998). Constitutional WT1 mutations in Wilms’ tumor patients. J. Clin. Oncol. 16: 3634-3640.

Cooper, P.R., Smilnich, N.J., Day, C.D., Nowak, N.J., Reid, L.H., Pearsall, R.S., Reece, M., Prawitt, D., Landers, J., Housman, D.E., Winterpacht, A., Zabel, B.U., Pelletier, J., Weissman, B.E., Shows, T.B., and Higgins, M.J. (1998). Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain. Genomics 49: 38-51.

Chu, L.L., Rutteman, G.R., Kong, J.M.C., Ghahremani, M., Schmeing, M., Misdorp, W., van Garderen, E., and Pelletier, J. (1998). Genomic organization of the canine p53 gene and its mutational status in canine mammary neoplasia. Breast Cancer Res. & Treatment  50: 11-25.

Dehbi, M., Hiscott, J., and Pelletier, J. (1998). Activation of the wt1 Wilms’ tumor suppressor gene by NF-kB. Oncogene 16: 2033-2039.

Bardeesy, N. and Pelletier, J. (1998). Overlapping RNA and DNA binding domains of the wt1 tumor suppressor gene product. Nucl. Acids Res. 26: 1784-1792.

Kim, J., Lee, K., and Pelletier, J. (1998). The desmoplastic small round cell tumor t(11;22) translocation produces EWS/WT1 isoforms with different oncogenic properties. Oncogene 16: 1973-1979.

Kim, J., Lee, K., and Pelletier, J. (1998). The DNA Binding Domains of the WT1 Tumor Suppressor Gene Product and Chimeric EWS/WT1 Oncoprotein Are Functionally Distinct. Oncogene 16: 1021-1030.

6Das, M., Chu, L.L., Ghahremani, M., Abrams-Ogg, T., Roy, M.S.,  Housman, D.,  and Pelletier, J. (1997). Characterization of an Abundant Short Interspersed Nuclear Element (SINE) Present in Canis familiaris. Mammalian Genome 9: 64-69.

Discenza, M.T., Dehbi, M., and Pelletier, J. (1997) Overlapping DNA Recognition Motifs Between Sp1 and a Novel Trans-Acting Factor within the wt1 Tumor Suppressor Gene Promoter. Nucleic Acids Research 25: 4314-4322.

Rodriguez, P., Munroe, D., Prwitt, D., Chu, L.L., Bric, E., Kim, J., Reid, L.H., Davies, C., Nakagama, H., Loebbert, R., Winterpacht, A., Petruzzi, M.-J., Higgins, M.J., Nowak, N., Evans, G., Shows, T., Weissman, B.E., Zabel, B., Housman, D., and Pelletier, J. (1997). Functional characterization of human nucleosome assembly protein-2 (NAP1L4) suugests a role as a histone chaperone.Genomics 44: 253-265.

Vicanek, C., Ferretti, E., Goodyer, C., Torban, E., Moffett, P., Pelletier, J., and Goodyer, P. (1997). Regulation of renal EGF receptor expression is normal in Denys-Drash syndrome. Kid. Int. 52: 614-619.

Moffett, P., Reece, M., and Pelletier, J. (1997). The murine Sim-2 gene product inhibits transcription by active repression and functional interference. Mol. Cell. Biol. 17: 4933-4947.

Kaplinsky, C., Ghahremani, M., Frishberg, Y., Rechavi, G., and Pelletier, J. (1996). Familial Wilms’ tumor associated with a WT1 zinc finger mutation. Genomics 38: 451-453.

Ghahremani, M., Chan, C.-B., Bistritzer,T., Aladjem, M., Tieder, M., and Pelletier, J. (1996) A Novel Mutation H373Y in the Wilms’ Tumor Suppressor Gene, WT1 Associated with Denys-Drash Syndrome. Hum. Heredity  46: 336-338.

Dehbi, M., and Pelletier, J. (1996). PAX8-Mediated Activation of the wt1 Tumor Suppressor Gene. EMBO J. 15:  4297-4306.

Bruening, W., Moffet, P., Chia, S., Heinrich, G., and Pelletier, J. (1996). Identification of nuclear localization signals within the zinc fingers of the WT1 tumor suppressor gene product. FEBS Letters 393: 41-47.

Rahman, N., Arbour, L., Tonin, P., Renshaw, J., Pelletier, J., Baruchel, S., Pritchard-Jones, K., Stratton, M.R., and Narod, S.A. (1996). Evidence for a familial Wilms’ tumour gene (FWT1) on chromosome 17q12-q21. Nature Genet. 13: 461-463.

Moffett, P., Dayo, M., Reece, M., McCormick, M.K., and Pelletier, J. (1996). Characterization of msim, a murine homologue of the Drosophila simGenomics  transcription factor. 35: 144-155.

Fuqua, J.S., Sher, E.S., Perlman, E.J., Urban, M.D., Ghahremani, M., Pelletier, J., Migeon, C.J., Brown, T.R., and Berkovitz, G.D. (1996). Abnormal gonadal differentiation in two subjects with ambiguous genitalia, Mullerian structures, and normally developed testes: evidence for a defect in gonadal ridge development. Hum Genet. 97: 506-511.

Mohammed, D., Ghahremani, M., Lechner, M., Dressler, G.,and Pelletier, J. (1996) The paired-box transcription factor, PAX2, positively modulates expression of the Wilms’ tumor suppressor gene (WT1). Oncogene 13: 447-453.

Bruening, W., and Pelletier, J. (1996). A non-AUG Translational Initiation Event Generates Novel WT1 Isoforms. J. Biol. Chem. 271: 8646-8654.

Li, F.P., Breslow, N., Morgan, J.M., Ghahremani, M., Miller, G.A., Grundy, P., Green, D., Diller, L.R., and Pelletier, J. (1996). Germline WT1 mutations in Wilms’ tumor patients: Preliminary Results. Medical and Pediatric Oncology 27: 404-407.

Moffett, P., Bruening, W., Nakagama, H., Bardeesy, N., Housman, D., Housman, D.E. and J. Pelletier. (1995) Antagonism of WT1 Activity by Self-Association. Proc. Natl. Acad. Sci. USA. 92: 11105-11109.

Schmitt, K., Zabel, B., Eitelberger, F., and Pelletier, J. (1995). Nephropathy with Wilms tumour or gonadal dysgenesis: incomplete Denys-Drash syndrome or separate diseases? Eur. J. Pediatr. 154: 577-581.

Gradi, A., Tang-Wai, R., McBride, H.M., Chu, L. L., Shore, G.C., and Pelletier, J. (1995) Molecular cloning and expression of the human Steroidogenic Acute Regulatory (StAR) protein. Biochem. Biophys. Acta. 1258: 228-233.

Edery, I., Chu, L.L., Sonenberg, N. and Pelletier J. (1995) An Efficient Strategy to Isolate Full-Length cDNAs Based on a mRNA Cap Retention Procedure (CAPture). Mol. Cell. Biol. 15: 3363-3371. 43. Goodyer, P., Dehbi, M.,Torban, E., Bruening, W., and Pelletier, J. (1995)Repression of the Retinoic Acid Receptor-alpha Gene by the Wilms' Tumor Suppressor Gene Product, wt1. Oncogene  10: 1125-1129.

Nakagama, H., Heinrich, G., Pelletier, J. and Housman, D. (1995) DNA Binding Specificity of the Wilms' Tumor Gene Product, and its Modulation by Zinc Finger I and the Flanking DNA Subsites. Mol Cell Biol. 15: 1489-1498.

Bardeesy, N., Beckwith, J.B., and Pelletier, J. (1995) Clonal Expansion and Attenuated Apoptosis in Wilms' Tumors are Associated with p53 Gene Mutations. Cancer Res.55: 215-219.

Bardeesy, N., Zabel, B., Schmitt, K. and Pelletier, J. (1994) WT1 Mutations Associated With Incomplete Denys-Drash Syndrome Define a Domain Predicted to Behave in a Dominant-Negative Fashion. Genomics21: 663-665.

Bardeesy, N., Falkoff, D., Petruzzi, M.-J., Nowak, N., Zabel, B., Adam, M., Aguiar, M.C., Grundy, P., Shows, T., and Pelletier, J. (1994) Anaplastic Wilms' tumors - A subtype displaying poor prognosis harbors p53 gene mutations. Nature Genet. 7: 91-97.

Varanasi, R., Bardeesy, N. Ghahremani, M., Petruzzi, M.-J., Nowak, N., Adam, M.A., Grundy, P., Shows, T., and Pelletier, J. (1994) Fine Structure Analysis of the WT1 Gene in Sporadic Wilms' Tumors. Proc. Natl. Acad. Sci. USA. 91: 3554-3558.

Mundlos, S., Pelletier, J., Darveau, A., Bachmann, M., Winterpacht, A., and Zabel, B. (1993) Nuclear localization of the protein encoded by the Wilms' tumor gene WT1 in embryonic and adult tissues. Development  119: 1329-1341.

Vogan, K., Bernstein, M., Leclerc, J.-M., Brisson, L., Brossard, J., Brodeur, G.M., Pelletier, J., and Gros, P. (1993) Absence of p53 Gene Mutations in Primary Neuroblastomas. Cancer Res. 53: 5269-5273.

Coppes, M., Huff, V., and Pelletier, J. (1993)  Denys-Drash Syndrome: Relating a Clinical Disorder to Genetic Alterations in a Tumor Suppressor Gene. J. Pediatrics. 123: 673-678.

Kreidberg, J.A., Sariola, H., Loring, J.M., Maeda, M., Pelletier, J., Housman, D., and Jaenisch, R. (1993) WT-1 is Required for Early Kidney Development. Cell  74: 679-691.

Bruening, W., Gros, P., Sato, T., Stanimir, J., Nakamura, Y., Housman, D., and Pelletier , J. (1993). Single-Strand Conformation Polymorphism (SSCP) Analysis of the Wilms' Tumor Suppressor Gene (WT1) in Ovarian Tumors. Cancer Investigations  11: 393-399.

Haber, D.A., Timmers, H.Th. Marc, Pelletier, J., Sharp, P.A., and Housman, D. (1992) A dominant mutation in the Wilms' tumor gene WT1 cooperates with the viral oncogene E1A in transformation of primary kidney cells. Proc. Natl. Acad. Sci. USA. 89: 6010-6014.

Bruening, W., Bardeesy, N.,Silverman, B.L., Cohn, R.A., Machin, G.A., Aronson, A.J.,  Housman, D., and  Pelletier, J. (1992) Germline intronic and exonic mutations in the Wilms’ tumour gene (WT1) affecting urogenital development. Nature Genetics1: 144-148.

Pelletier, J., Bruening, W., Kashtan, C.E., Mauer, S.M., Manivel, J.C., Striegel, J.E., Houghton, D.C., Junien, C., Habib, R., Fouser, L., Fine, R.N., Silverman, B.L., and  Housman, D. (1991). Germline Mutations in the Wilms' Tumor Suppressor Gene Disrupt Urogenital Development in Humans. Cell. 67:437-447.

Pelletier, J., Bruening, W., Li, F., Haber, D., Glaser, T., and Housman, D. (1991). WT1 Mutations Contribute to Abnormal Genital System Development and Hereditary Wilms' Tumour Nature  353: 431-434.

Haber, D.A., Sohn, R.L., Buckler, A.J., Pelletier, J., Call, K.M., and Housman, D. (1991). Alternative Splicing and Genomic Structure of the Wilms' tumor Gene WT1. Proc. Natl. Acad. USA. 88: 9618-9622.

Pelletier, J., Schalling, M., Buckler, A.J.,  Haber, D.A., and Housman, D. (1991). Expression of the Wilms' tumor gene WT1 in the murine urogenital system. Genes & Dev. 5: 1345-1357.

Pelletier, J., Brook, J.D., and Housman, D. (1991). Assignment of Two of the Translation Initiation Factor-4E (EIF-4E) Genes to Human Chromosomes 4 and 20. Genomics. 10: 1079-1082.

Buckler, A.J., J. Pelletier, D.A. Haber, T. Glaser, and D.E. Housman. (1991). Isolation, characterization, and expression of the murine Wilms' tumor gene (WT1) during kidney development. Development. Mol. Cell. Biol.  11: 1707-1712.

Pritchard-Jones, K., S. Fleming, D. Davidson, W. Bickmore, D. Porteous, C. Gosden, J. Bard, A. Buckler, J. Pelletier, D. Housman, V. van Heyningen, and N. Hastie. (1990). The Candidate Wilms' Tumor gene is Involved in Genitourinary Development. Nature  346: 194-197.

Haber, D.A., A.J. Buckler, T. Glaser, K.M. Call, J. Pelletier, R. L. Sohn, E.C. Douglass, and D.E. Housman. (1990). An Internal Deletion Within an 11p13 Zinc Finger Gene Contributes to the Development of Wilms' Tumor. Cell  61: 1257-1269.

Call, K.M., T. Glaser, C.Y. Ito, A.J. Buckler, J. Pelletier, D.A. Haber, E.A. Rose, A. Kral, H. Yager, W.H. Lewis, C.A. Jones, and D.E. Housman. (1990). Description and Characterization of a Zinc Finger Polypeptide Gene at the Human Chromosome 11 Wilms' Tumor Locus. Cell  60: 509-520.

Jaramillo, M., Pelletier, J., Edery, I., Nielsen, P.J., and Sonenberg, N. (1991). Multiple mRNAs Encode the Murine Translation Initiation Factor eIF-4E. J. Biol. Chem. 266: 10446-10451.

Nicholson, R., Pelletier, J., Le, S.-Y., and Sonenberg, N. (1991). Structural and Functional Analysis of the Ribosome Landing Pad of Poliovirus  type 2: In VivoJ. Virology.  Studies.   65 : 5886-5894.

Altmann, M., Blum, S., Pelletier, J., Sonenberg, N., Wilson, T.M.A., and Trachsel, H. (1990). Translation initiation factor-dependent extracts from Saccharomyces cerevisiae. Biochem. Biophys. Acta  1050: 155-159.

Davies, M.V., J. Pelletier, K. Meerovitch, N. Sonenberg, and R.J. Kaufman. (1991). Expression of Poliovirus Proteinase 2Apro  Expression on Cellular Metabolism. J. Biol. Chem. 266: 14714-14720.


Rozen, F., J. Pelletier, H. Trachsel, and N. Sonenberg. (1989). A Lysine Substitute  in the ATP Binding Site of Eukaryotic Initiation Factor-4A Abrogates Nucleotide Binding Activity. Mol. Cell. Biol. 9: 4061-4063.

Meerovitch, K., J. Pelletier, and N. Sonenberg. (1989). A Cellular Protein that Binds to the 5' Noncoding Region of Poliovirus RNA:Implications for Translation Initiation. Genes & Devel. 3: 1026-1034.

Altmann, M., P.P. Muller, J. Pelletier, N. Sonenberg, and H. Trachsel. (1989). A Mammalian Translation Initiator Factor can Substitute for its Yeast Homologue In Vivo. J. Biol. Chem. 264: 12145-12147.

Boylan, M.O., J. Pelletier, and E.A. Meighen. (1989). Fused Bacterial Luciferase  Subunits Catalyze Light  Emission in Eukaryotes and Prokaryotes. J. Biol. Chem. 264: 1915-1918.

Boylan, M.O., J. Pelletier, S. Dhepagnon, S. Trudel, N. Sonenberg, and E.A. Meighen. (1989). Construction of a Fused Lux AB Gene by Site-directed Mutagenesis. J. Biolum. Chemilum. 4: 310-316.

Pelletier, J. and N. Sonenberg. (1989). Internal Binding of Eukaryotic Ribosomes on Poliovirus RNA: Translation in HeLa Extracts. J. Virol. 63: 441-444.

Pelletier, J. , M.E. Flynn, G. Kaplan, V.R. Racaniello, and N. Sonenberg. (1988) Mutational Analysis of the Upstream AUG Codons of Poliovirus RNA. J. Virol. 62: 4486-4492.

Pelletier, J. and N. Sonenberg. (1988). Internal Initiation of Translation of Eukaryotic mRNA Directed by a Sequence Derived from Poliovirus RNA. Nature  334: 320-325.

Trono, D., J. Pelletier, N. Sonenberg, and D. Baltimore. (1988). Translation in Mammalian Cells of a Gene Linked to the Poliovirus 5' Noncoding Region. Science 241: 445-448.

Pelletier, J., G. Kaplan, V.R. Racaniello, and N. Sonenberg. (1988). Translational Efficiency of Poliovirus mRNA:  Mapping Inhibitory cis-Acting Elements within the 5' Noncoding Region. J. Virol. 62: 2219-2227.

Milburn, S.C., J. Pelletier, N. Sonenberg, and J.W.B. Hershey. (1988). Identification of the 80-kDa Protein that Crosslinks to the Cap Structure of Eukaryotic mRNAs as Initiation Factor eIF-4B. Arch. Biochem. 264: 348-350.

Pelletier, J. G. Kaplan, V.R. Racaniello, and N. Sonenberg. (1988). Cap-Independent  Translation of Poliovirus mRNA is Conferred by Sequence Elements Within the 5' Noncoding Region. Mol. Cell. Biol. 8: 1103-1112.

Pelletier, J., R. Nicholson, R. Bassel-Duby, B.N. Fields, and N. Sonenberg. (1987). Expression of Reovirus Type 3 (Dearing Strain) sigma 1 and sigma s Polypeptides in Escherichia coli. J. Gen. Virol. 68: 135-145.

Pelletier, J. and N. Sonenberg. (1985). Photochemical Crosslinking of Cap Binding  Proteins to Eukaryotic mRNAs: Effect of mRNA 5' Secondary Structure. Mol. Cell. Biol. 5: 3222-3230.

 Sarkar, G., J. Pelletier, R. Bassel-Duby, A. Jayasuriya, B.N. Fields, and N. Sonenberg. (1985). Identification of a new Polypeptide Coded by Reovirus Gene S1. J. Virol. 54: 720-725.

Darveau, A., J. Pelletier, and N. Sonenberg. (1985). Differential Efficiences of In Vitro Translation of Mouse c-myc Transcripts Differing in the 5' Untranslated Region. Proc. Natl. Acad. Sci. USA  82: 2315-2319.

Pelletier, J. and N. Sonenberg. (1985). Insertion Mutagenesis to Increase Secondary  Structure Within the 5' Noncoding Region of a Eukaryotic mRNA Reduces Translational Efficiency. Cell  40: 515-526.

Book Chapters and Reviews.

Pelletier, J., Sonenberg, N., Graff, J., (2015). Targeting the eIF4F translation initiation complex: A critical nexus for malignancy. Canc. Research 75:250-263.

Bhat, M., Robichaud, N., Hulea, L., Sonenberg, N., Pelletier, J., and Topisirovic. (2015) Targeting the translation machinery in cancer. Nature Rev. Drug Dis. 14: 261-278

Malina, A., Katigbak, A., Cencic, R., Maïga, R.I., Robert, F., Miura, H., and Pelletier, J. (2014) Adapting CRISPR/Cas9 for functional genomics screens. Methods Enzymology. 546: 193-213

David Shahbazian, Jerry Pelletier, Yuri Svitkin, John W. B. Hershey, and Armen Parsyan (2014). RNA Helicases and Their Cofactors. In “Translation and its Regulation in Cancer Biology and Medicine.” (ed., Armen Parsyan)    

Galicia-Vazquez, G. and Pelletier, J. (2014). Current and Emerging Therapies Targeting Translation. In “Translation and its Regulation in Cancer Biology and Medicine.”(ed., Armen Parsyan)    

Robert, F., and Pelletier, J. (2013) Perturbations of RNA Helicases in Cancer. Wiley Interdiscip Rev RNA. 4: 333-349.

Cencic, R. and Pelletier, J. (2013). Throwing a Monkey Wrench in the Motor: Targeting DExH/D box Proteins with Small Molecules. (eds., Frances Fuller-Pace and Patrick Linder) BBA Reviews, In Press.

Nasr, Z., and Pelletier, J. (2012). Tumor Progression and Metastasis: Role of Translational Deregulation. Anticancer Research. 32: 3077-3084.

Cencic, R.,  Galicia-Vazquez, G., and Pelletier, J. (2012). Inhibitors of Translation Targeting Eukaryotic Initiation Factor 4A. In Methods in Enzymology – RNA Helicases: Analysis of Molecular Mechanisms and Biological Functions (ed. Eckhard Jankowsky). 511: 437 – 461.

Malina, A., Mills, J., and Pelletier (2012). Emerging Therapeutics Targeting mRNA Translation. In. “Cold Spring Harbor Perspective Biol.” (Matthews, M., Sonenberg, N., and Hershey, J.W.B.). 4: a012377.

Lee, T and Pelletier, J. (2012). Eukaryotic Initiation Factor 4F: A Vulnerability of Tumor Cells. Future Medicinal Chemisty. 4: 19-31.25. Malina, A., Cencic, R., and Pelletier, J. (2011). Targeting Translation Dependence in Cancer. Oncotarget. 2:  76-88.

Pelletier, J. and Graff, J.R. (2010) Downstream from mTOR: Therapeutic Approaches to targeting the eIF4F translation initiation complex. In “mTOR Pathway and mTOR Inhibitors in Cancer Therapy” (V.A. Polunovsky and P.J. Houghton, eds.) [Humana Press] p. 257-285.23. Lindqvist, L., and Pelletier, J. (2009). Translating protein synthesis inhibitors into Cancer Therapeutics. Future Medicinal Chemisty. 1: 1709-1722.

Robert, F., and Pelletier, J. (2009). Translation Initiation: A critical signalling node in cancer. Expert Opin. Ther. Targets. 13: 1279-1293.

Lin, C.-J., Malina, A., and Pelletier, J. (2009). C-Myc and eIF4E constitute a feedforward loop that regulates cell growth: Implications for anti-cancer therapy. Cancer Res. 69: 7491-7494.

Pelletier, J., Mazroui, R., Sukarieh, R., Harvey, I., and Gallouzi, I. (2008). “Stress Granules in Cell Survival.” In RNA Binding Proteins in Development and Disease. “ [ed. Robert B. Denman] p.13-33.

Cencic, R., Robert, F., and Pelletier, J. (2007). Identifying small molecule inhibitors of eukaryotic translation initiation. Methods in Enzymology. 431: 269-302.

Pelletier, J. and Peltz, S.W. (2006). Therapeutic Opportunities in Translation. In “Translational Control in Biology and Medicine” (Matthews, M., Sonenberg, N., and Hershey,  J.W.B.).

Discenza, M., and Pelletier, J. (2004). Insights into the physiological role of WT1 from studies of genetically modified mice. Physiol. Genomics 16: 287-300.

Das, M., Harvey, I., Chu, L.L., Sinha, M., and Pelletier, J. (2001). Full-length cDNAs: more than just reaching the ends. Physiol. Genomics 6: 57-80.

Kim, J. and Pelletier, J. (1999). Molecular genetics of chromosome translocations involving EWS and related family members. Physiol. Genomics 1, 127-138.

Pelletier, J. (1996). Affinity Selection of Eukaryotic mRNAs and Full-length cDNAs by a Cap Retention Procedure (CAPture). In “Gene Cloning and Analysis”. (B.C. Schaefer, ed.) [Horizon Scientific Press] p. 81 - 98.

Pelletier, J., Nakagama, H., and Housman, D. (1996). Cancer Genes: Functional Aspects. (ed. H. Mihich and D. Housman). Pezcoller Foundation Symposia. Vol. 7, pp. 103-122.

Bardeesy, N. and Pelletier, J. (1995) Mutational Detection by Single Strand Conformational Polymorphism.  In  “PCR in Neuroscience.” (G. Sarkar, ed.) [Academic Press, New York] p.163-183.

Bruening, W., Winnett, E., and Pelletier, J. (1995) Wilms' tumor: A paradigm for insights into development and cancer. Cancer Investigations. 13(4): 431-443.

Bruening, W. and Pelletier, J. (1994) Denys-Drash syndrome: A role for the WT1 tumor suppressor gene in urogenital development. Seminars in Developmental Biology  5: 333-343.

Pelletier, J. (1994)  Molecular Genetics of Wilms' Tumor - Insights into Normal and Abnormal Renal Development. Can. J. Oncol.  4(2), 262-272.

Lowe, S.W., Bodis, S., Bardeesy, N., McClapchey, A., Remington, L., Ruley, H.E., Fischer, D.E., Jacks, T., Pelletier, J., and Housman, D. (1994) Apoptosis and the prognostic significance of p53 Mutations. In Cold Spring Harbor Symposia on Quantitative Biology. (Cold Spring Harbor Laboratories). Vol 59. pp. 419-426.

Pelletier, J., Munroe, D., and Housman, D.(1991). Molecular Genetics of Wilms' Tumor. In 'Genome Analysis Vol 3: Genes & Phenotypes'. Cold Spring Harbor Laboratory Press, N.Y. pp 135-169.

Pelletier, J., Haber, D., and Housman, D. (1991). Genetics of Wilms' Tumor. In "Origins of Human Cancer". (J. Brugge, T. Curran, E. Harlow, F. McCormick, eds.) Cold Spring Harbor Laboratory Press, N.Y.

Meerovitch, K., J. Pelletier, and N. Sonenberg. (1990). The Translation of Picornaviruses. In "Translation in Eukaryotes" (Trachsel, H., ed.)

Sonenberg, N. and J. Pelletier. (1989). Poliovirus Translation: A Paradigm for a Novel Initiation Mechanism. Bioessays  11:  128-132.

Edery, I., J. Pelletier, and N. Sonenberg. (1987). Role of Eukaryotic RNA Cap-Binding Protein in Regulation of Translation. In "Translational Regulation of Gene Expression." (Ilan, J., ed.) Plenum Press, New York, pp. 335-366.

Pelletier, J. and N. Sonenberg. (1987). The Involvement of mRNA Secondary Structure in Protein Synthesis. Biochem. Cell. Biol. 65: 576-581.

Sonenberg, N., I. Edery, G. Sarkar, and J. Pelletier. (1986). Eukaryotic mRNA Cap Binding Protein Complex and 5' mRNA Secondary Structure: Studies in Uninfected and Poliovirus-Infected Cells. In "Current Communications. Molecular Biology - Translational Control." (Mathews, M.B., ed.) Cold Spring Harbor Laboratory, New York pp. 30-34.